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GEN Path > Wound Healing > Flashcards

Wound Healing Flashcards

1
Q

What is deposited mostly during scar formation?

A

CT mostly collagen

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2
Q

What plays a central role in the repair process?

A

Macrophages

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3
Q

Repair Sequence: Day 1?

A

Neutrophils migrate in and phagocytose foreign substances and necrotic tissues

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4
Q

Repair Sequence: Day 2?

A

Macrophages enter
Granulation tissue (capillaries and immature fibroblast)
Protected by Fibrin clot

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5
Q

Repair Sequence: Day 3-6?

A

Lymphocytes and plasma cells

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6
Q

Repair Sequence: Day 7?

A

Clot digested, initial repair complete

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7
Q

Repair Sequence: Day 14?

A

Fibroblast mature, collagen remodeled, scar tissue

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8
Q

When is regeneration not possible (2 things)?

A

Permanent Tissues
Extensive ECM damage

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9
Q

What does fibrosis mean?

A

Excessive scar tissue, often seen in chronic inflammation

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10
Q

What makes fibroblast growth factor (FGF)?

A

Macrophages

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11
Q

Migration and proliferation of fibroblast is mediated by what?

A

FGF

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12
Q

Migration and proliferation of fibroblast and smooth muscle cells is mediated by what?

A

PDGF (platelet derived growth factor)

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13
Q

What does Vascular endothelial growth factor mediate (VGEF)?

A

New blood vessels

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14
Q

What day does granulation tissue typically appear?

A

Day 3-5

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15
Q

What mediates fibroblast depositing collagen?

A

TGF-B

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16
Q

What stimulates production of collagen and inhibits breakdown of ECM proteins (anti-inflammatory)?

A

TGF-B

17
Q

What degrades ECM proteins?

A

Matrix Metalloproteinases

18
Q

What is a part of the remodeling process?

A

Matrix Metalloproteinases

19
Q

What inhibits Matrix Metalloproteinases?

A

tissue inhibitors of metalloproteinases (TIMPs)

20
Q

IL-___ stimulate collagen synthesis and fibroblast migration

A

13

21
Q

IL-13 stimulates two things?

A

Collagen synthesis
Fibroblast migration

22
Q

What is released as inactive precursors and then activated by proteases at the site of injury? They will degrade ECM proteins.

A

Matrix Metalloproteinases

GEN Path (1 decks)

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