WOUND HEALING

Question 1

Four phases of wound healing

Answer 1

Hemostasis
Inflammation
Proliferation (granulation and contraction)
Remodeling (maturation)

Question 2

Inflammation: Duration, cells involved, function

Answer 2

1-4 days
Neutrophils, Macrophages, Monocytes
Phagocytosis

Question 3

Proliferation: Duration, cells involved, function

Answer 3

4-21 days
Pericytes, Lymphocytes, Angiocytes, Neurocytes, Fibroblasts, Keratinocytes, Epithelial
Angiogenesis, Collagen deposition, granulation tissue formation, wound contraction, and epithelialization

Question 4

Remodelling: Duration, cells involved, function

Answer 4

21 d - 2 yrs
Fibroblasts, Fibrocytes
Develop tensile strength

Question 5

Most important micronutrient’s associated with wound healing

Answer 5

iron, zinc and vitamins A and C

Question 6

Risk factors for delayed wound healing

Answer 6

increased bacterial burden
presence of devitalized tissue
chronic ischemia
repetitive trauma

Question 7

Tensile strength: 6 weeks vs. 100 days

Answer 7

6 weeks - 60%
100 days - full healing