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Word Association Flashcards

1
Q

Pyogenic granuloma

A

Reactive hemangioma
Strabismus, PTX
Spoke wheel vascular pattern

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2
Q

Macular dystrophy

A 
AR
Stromal
Mucopolysaccaride
Alcian blue
Diffuse haze over all of K
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3
Q

Cysts on cornea biopsy

A 
Acanthamoeba
Polyhexamethylene biguanide (PHMB) +/- propamide
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4
Q

Hearing loss and interstitial keratitis

A

Cohan Syndrome

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5
Q

Kaiser Fleischer Ring

A

Wilson’s disease
Chronic active hepatitis
Primary biliary cirrhosis
Exogenous chalcosis

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6
Q

TGFbeta

A 
Granular
Lattice
Avellino
Reis Buckler
Thiel Benke
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7
Q

Goblet cells in the corneal epithelium

A

Limbal stem cell deficiency

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8
Q

Corneal type 1 collagen

A

Stroma, Bowman’s

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9
Q

Corneal type 4 collagen

A

Descemet

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10
Q

Corneal type 3 collagen

A

Scar tissue

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11
Q

PAS positive membrane

A

Descemets, lens capsule, basement membrane of the pigmented ciliary body epithelium, ILM, Bruch’s membrane

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12
Q

Anterior bandes and posterior nonbanded

A

Descemets — posterior nonbanded thickens over life

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13
Q

Corneal endothelium with epithelial characteristics

A
  • ICE
  • Epi downgrowth
  • PPMD
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14
Q

Anterior v posterior lens capsule

A

Anterior - w epi, 12-21 microns

Posterior - no epi, 2-9 microns

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15
Q

Eosinophilic processes

A

Allergy
Parasitic
Sympathetic ophthalmia

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16
Q

Giant cells in descemets

A

Herpetic disease

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17
Q

Golden globules

A

Actinic keratopathy = labrador

May look like band

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18
Q

Enlarged corneal nerves

A 
MEN2B
Leprosy = Hansen
Phytanic acid storage dz = Refsum
NF
Familial dysautonomia
Acanthamoeba
19
Q

MEN2B

A 
Enlarged corneal nerves
Medullary thyroid carcinoma
Pheo 
Marfanoid habitus
Mucosal neuroma
20
Q

Refsum Disease

A

Phytanic acid storage
Juvenile onset nyctalopia, cataract, RP
Hearing loss, ataxia,ichthyoses
AR

21
Q

Parkinson syndrome

A

Exposure keratopathy (slow blink)

22
Q

Etiologies of neurotrophic keratopathy

A
  • Aneurysm/CVA
  • CN V damage (iatrogenic eg large LRI, PK, LASIK)
  • Tumor (acoustic neuroma, angioma, neurofibroma)
  • DM
  • Riley-Day = Familial Dysautonomia
  • HSV/VZV
  • Leprosy (Hansen Dz)
  • MS
  • Med toxicity (anesthetic, beta blocker, CAI, NSAID)
23
Q

Medication classes associated with corneal anesthesia

A 
Topical anesthetics
Beta blockers
CAIs
NSAIDs
Preservative: BAK = benzalkonium chloride
24
Q

Preservative associated with K anesthesia

A

Benzalkonium chloride = BAK

25
Heaped up corneal epithelium around an epi defect; associated strongly infiltration
Neurotrophic keratopathy
26
Superior Limbic Keratoconjunctivitis associations
``` Autoimmune thyroid disease Graft v host Post-blepharoplasty Aqueous tear deficiency Blepharospasm ``` Mechanical trauma to upper lid transmitted to bulbar/tarsal conjunctiva
27
Superior limbic keratoconjunctivitis - presentation
Chronic-recurrent Female predominant Often bilateral; can be asymmetric Injection/thickening superior bulbar conj Fine papillary reaction superior tarsal conj Hypertrophie superior limbus Superior PEE Superior filaments (distinguishes from CLK) Good vision (distinguishes from CLK)
28
Snake nuclei
SLK: superior bulbar conj - chromatin changes Other cellular features: nuclear pyknosis w increased cytoplasm-nucleus ratio Also associated: goblet cell loss, keratinization, hyperproliferation, acanthosis
29
Management of conjunctivochalasis
Med: topical lubricants, antihistamines, topical steroids Other: patch at night Procedural: cautery, amniotic tissue graft, excision (consider closure w tissue adhesive)
30
Slit lamp findings in traumatic recurrent erosion
Epi cyst on retroillumination Fluorescein pooling To distinguish dystrophy from trauma, examine contralateral eye while dilated: if weck cell pressure demonstrates loosely adherent epi, consider dystrophy
31
Treatment: traumatic recurrent erosion
``` Conservative: Lubrication Patching Topical abx Muro—min 6 wk Doxy- anti-MMP Steroid +/- BCL ``` ``` Surgical: Epi debridement Anterior stromal puncture PTK PRK ```
32
Trichiasis v dystichiasis
Trichiasis - normal origin, turned in | Distichiasis - extra row of lashes from Meibomian gland orifice
33
Corneal abnormality associated with Finnish ancestry
Cornea plana (KERA gene: 12q22; AR/AD) Associated with: corneal clouding, sclerocornea, cataract, coloboma (anterior or posterior), angle closure, POAG Associated w Ehlers Danlos
34
FOXC1
Axenfeld Rieger - posterior embryotoxin - iris abnormalities (hypoplasia/corectopia) - glaucoma - craniofacial abnormalities A spectrum Also ass’d w: PITX, PAX6
35
SRK-T
P = A - 2.5L -0.9K
36
BIGH3
Granular Hyaline Masson Trichrome Central symptoms Clear periphery Also: Avellino (AD), Reis-Bucklers (AR)
37
Type of dry eye associated with lactoferrin
Indirect measure of lacrimal gland function (produced by lacrimal acini) -- associated with aqueous tear deficiency
38
Type of dry eye associated with MMP-9
Suggestive of blepharitis -- evaporative dry eye
39
Type of dry eye associated with tear osmolarity
Values of 306-308 mOsm/L suggest aqueous tear deficiency
40
Conjunctival lymphomatous processes -- likelihood of systemic lymphoma
20% lymphoid tumor have extraocular lymphoma 31% of lymphoma have extraocular lymphoma Also, bilateral in 20% Typically non-Hodgkin's B cell lymphoma
41
Diffuse, forniceal salmon-colored conjunctival thickening
Conjunctival lymphoid tumor v. lymphoma - Fresh for IHC - 20% b/l - High rate of extraocular lymphoma
42
Four Ps of Hemansky-Pudlak
- Platelet disorder (bleeding diathesis) - Pulmonary fibrosis - Puerto Rican descent - Pigmentless (oculocutaneous albinism)
43
Chediak-Higashi
- Oculocutaneous albinism - Neutropenia -- high susceptibility to infection - Myeloblasts/promyelocytes with large, eosinophilic inclusion bodies - Peculiar malignant lymphoma

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