womens health Flashcards
the 5 Ps of taking a history
Partners Practices (what type) Prevention Protection Past hx of STI
Special populations STI
Youth 15-24 MSM Pregnant HIV Correctional facility
3 most common sx of Vaginitis
discharge
odor
pruritis/discomfort
3 mosts common causes of Vaginitis
Yeast infection, BV, Trich
Yeast infection
highest prev in reproductive years
C albicans
Yeast infection
Pruritis, vulvar soreness
White, thick, curd like, adherent to vaginal walls
Yeast infection risk factors
DM
Abx use
Inc estrogen levels
Immunosupp
Dx of Yeast infection
Wet mount 10% KOH: budding yeast, hyphae, or pseudohyphae
tx of Yeast infection
Oral Fluconazole (Diflucan) OR OTC topical azole (Clotrimazole)
Tx for Yeast infection in pregnant
Need to use topical (Clotrimazole or Miconazole)
BV
most common cause of discharge among women of childbearing age!***
BV
Malodorous, “fishy”, thin off white d/c
Dx criteria for BV
Amsel's, need at least 3 of the following: -thin, white, homo d/c -CLUE CELLS -ph >4.5 \+whiff test
Tx of BV
Metronidazole (Flagyl) 500 mg BID x 7 days
OR gel or clinda cream
What to avoid while taking Metronidazole (Flagyl)
drinking alcohol
Trich
most common non-viral STI in the world
Are sx common with Trich?
NO
most have minimal or no sx (70-85%)
Sx of Trich
Purulent, frothy, thin
malodorous d/c
POSTCOITAL BLEEDING
pain w/intercourse
Trich
flagellated protozoan
PE of Trich
“Strawberry cervix”
vaginal ph >4.5
Dx of Trich
NAAT: gold standard
Tx of Trich
Metronidazole (flagyl) 2g of one single dose
can do 500 mg BID if pregnant, much weaker dose
Chlamydia
most common reported BACTERIAL STD in AMERICA
Clinical sx and PE of Chlamydia and Gon are IDENTICAL
Cervicitis: change in d/c, intermenstrual/post intercourse bleeding OR sx related to urethritis
PE: mucupur endocervical d/c, FRIABLE cervix, erythema, edema
Dx of Chlam and Gon
NAAT
Complication of Chlam
Conjunctivitis of Neonate
Gonorrhea
2nd most common reportable communicable dz in AMERICA
concern with ABX RESISTANCE
Complications of Gonn
Transmissable to neonate during delivery
DGI (arthritis)
Tx of Chlamydia
Azithro or
Doxy
Tx of Gonorrhea (more)
Azithro AND
Ceftriazone (rocephin)
Screening for Gon/Chlam
Yearly for all sexually active women <25YO, AND
older with risk factors
PID
upper genital tract (ascending)
often a comp of Gon/Chlam or BV-assoc pathogens
PID
wide array of clinical sx
PID physical
Abdominal tenderness (lower quadrants) Uterine, adnexal, or CVA tenderness "chandelier sign"
A manifestation of PID (on boards!!!)
Perihepatitis: Fitz Hugh Curtis Syndrome
inflammation of liver capsule and neighboring peritoneal surfaces
PID, RUQ pain, “violin string” lesions on liver
What to order if suspicous of PID
Pregnancy test!! Pelvic US (if unsure) microscopy of d/c NAAT (r/o Gon/Chlam) HIV screen, syphillis screen UA CBC, ESR/CRP
Gold standard test for Gon/Chlam
NAAT
Criteria for presumptive clinical dz of PID
Sexual active young women
Pelvic/lower abd pain
Cervical motion, uterine, or adnexal tenderness
(“Chandelier”)
Tx for PID
Ceftriaxone (rocephin) AND
Doxy
Most common STI in the WORLD
HPV- condyloma acuminata, anogenital warts
most common types of warts
strand 6 and 11
Risk factors of HPV
sexual activity
smoking
immunosuppression
Tx of HPV (warts)
Cyto destructive: Podoflox
Immune med: Imiquimod, Sinecatechins
Surgical: cryotherapy, laser, electrocaut
Types of Herpes
Primary: person HAS pre-existing antibodies
Non primary first episode: start of HSV2 in person that had HSV1 antibodies, or vice versa
Recurrent: of genital
Tx of Herpes
FAV drugs
“cyclovir”
start within 72 hours
1st episode: 7-10 days
Recurrent: 1-5 days
suppression: BID, daily
Mullerian ducts give rise to:
Fallopian tubes
Uterus
Upper vagina
Normal female puberty: FSH/LH stimulates production of
Estradiol from ovaries
Estradiol –>
breast development and growth of skeleton
Average age of menses and menopause
menses: 12-13 YO
menopause: 51 YO
Avg menstrual cycle
24-38d
Amount of blood loss during menses
5-80mL
Primary amenorrhea
Failure to reach menses (never start)
by age 15 w normal growth and secondary charac (like breasts)
OR
by age 13 w/o secondary charac (so more than just menses is missing)
Secondary amenorrhea
Cessation of menses (stops after it once started)
Absence for more than 3 cycle intervals
OR
6 consecutive mo
Most common cause of Primary amenorrhea
Gonadal dysgenesis (ovarian dysfx)
Gonadal dysgenesis
most comm cause of Primary amenorrhea
Abnormal organ development
Hyper Hypogonadism (high FSH)
Turner syndrome
46 XO
Ovaries can’t respond to gonadotropins
Result: premature depletion of oocytes and follicles
Woman does NOT ovulate or have periods
Turner syndrome clinical sx
“shield chest”
webbed neck
widely spaced nipples
“Streak ovaries” and sexual infantilism
Swyer Syndrome
46 XY gonadal dysg
“Vanishing testes”
Fibrous streak gonad can’t secrete Anti’-M hormone or testosterone
Mutation of SRY gene
46XY Swyer
Gonads fail to diff into testes
Lack of Anti-M, testosterone, and DHT results in FEMALE INTERNAL and EXTERNAL genitalia
everything appears to be girl, but genetically a male
PCOS
rare cause of primary amenorrhea
Rare cause of primary amenorrhea
Hyperandrogenism- acne, hirsutism, acanthosis nigricans, obesity
Female athlete triad
Not enough calorie intake
Amenorrhea
Low bone density
Functional hypothalamic amenorrhea
HPO axis suppressed bc not eating enough
leading to abnormal GnRH secretion –> no follicle develop/ovulation –> Low estradiol secretion –> NO LH surge
Idiopathic Hypo Hypo
Congenital GnRH deficiency
if no smell, “Kallmann” synd
Pituitary causes of Primary amenorrhea
Micro/Macro-Adenoma (i.e. cushings)
Hyperprolactinemia (BUT this one is more associated w Secondary amenorrhea)
these two are most common
VERY COMMON causes of Primary: Outflow tract disorders
Uterine-Mullerian agenesis
- 46 XX with no oviducts, uterus, or upper vagina. instead have a small pouch rather than full vaginal canal.
- Normal gonadal function (estrogen = breast devel)
Rare cause of primary amenorrhea
Androgen Insensitivity Synd
Genetically male, looks femaile, high testosterone
Breasts, Absent upper vagina, uterus, and fallopian tubes on Pelvic US
Testes are STILLL THERE, intra abdominal or partially descended. Need to be removed d/t CA risk
Rare cause of Primary Amenorrhea
5-a-reductase deficiency
-46XY unable to convert DHT–>T
ambiguous genitalia at birth
17-a-hydroxylase deficiency
HTN and Lack of pubertal development
d/t decreased Cortisol synth and lack of sex steroids
Biggest cause of Secondary Amenorrhea
Pregnancy!
PCOS
Androgen excess
Chronic amenorrhea or oligomenorrhea
Polycystic ovaries
Peripheral insulin resistance
Asherman synd
cause of Secondary amenorrhea
Scarring of endometrial lining caused by OBGYN procedure
Hx of weight loss, strenuous exercise, eating disorder?
Dx Sec Amenorrhea
Hypothalamic disorder
anorexia, exercise, stress induced
Hx of surgical procedure or infection
Dx Sec Amenorrhea
Asherman syndrome
HA, visual change, Galactorrhea
Dx Sec Amenorrhea
Infiltrating Pituitary dz/tumor
Sheehan synd
Illness, CA, infection, RA
Dx Sec Amenorrhea
Can simply be d/t systemic illness
When to start evaluating for Primary amenrrhea
No menses by:
age 15
age 13 AND no breast
No menses after 3 yrs of having breasts
Normal order of development for women
Breast
Pubic hair
Growth spurt
Menses
Tests to oder when working up Amenorrhea
Pregnancy test (hcG)
FSH
TSH
Prolactin
What to order if pt has Short stature and elevated FSH
Karyotype
Turner synd
What to order if pt has low/norm FSH, breasts, but NO uterus
Karyotype (Mullerian agenesis) Total Testosterone (Androgen Insens Synd)
What to order if pt has low/norm FSH, breast, AND uterus is present
Consider endocrine: PCOS, thyroid
If hyperandrogenism: order Total Testosterone and DHEA