Women's Health Flashcards
Normal vagina
In normal mature vagina: 95% of organisms are lactobacillus ( vaginal flora):
-Hello to create an acidic environment PH 4-5
-conversion of glycogen to lactic acid
-acidic environment help to protect the vagina from infection with other bacteria
Vaginal discharge is normal ( increased during pregnancy, ovulation, after menses)
Bacterial Vaginosis
Thin, watery, fishy odor, discolored
Trichromoniasis
Frothy, copious, malodorous, discolored
Vulvovaginal candidiasis
Thick, cottage cheese like, no odor, normal pH
Vulvovaginal disorders
Many women who purchased nonprescription anti fungal products to treat vaginal symptoms actually did not have VVC symptoms
Non infectious conditions such as irritation or pruritus caused by allergic runs secondary to douching feminine hygiene products, latex rxns, spermicides or soaps may also add to the conclusion of diagnosis vaginal infection
Inappropriate use of vaginal anti fungal products
Unnecessary drugs use
Delay in effective treatment for actual conditions
Cost
Recommended the use of vaginal pH self testing device
VVC ( aka yeast infection)
Infectious agent
Candida fungi are the primary causative agent
- Candida albicans
VVC causes
High dose combined oral contraceptives Estrogen Pregnancy Corticosteroids use Food high in sugar Clothing tight fitting, nonabsorbent Vagisil screening kit is available but has problems: - vaginal swan to determine pH and pH <4.5 is favorable
Treatment goals for VVC
Relief of symptoms
Eradication of the infection
Reestablishment of normal vaginal flora
Uncomplicated VVC
May be candidate for self care
Infrequent episodes
Mild-moderate symptoms
Complicated VVC
More severe symptoms
Predisposing illness or medications
Recurrent VVC
-at least 4 documented infections/1 year period
- may be early signs of HIV or DM
-more resistant to imidazole anti fungal therapy
Need to be further evaluated by PCR
FDA warnings: symptoms that return within 2 months or infections that do not clear up easily upon treatment require medical evaluation
Exclusions to self care
Medically diagnosed with VVC at least once
Younger than 12 years old
Pregnant
Diabetes mellitus
HIV positive or aids
Have impaired immune system, including use of medications that may impair function of the immune system
Nonpharmacologic therapy if VVC
Change diet: decrease sugar Life cultures yogurt Changing to low dose COC Talk to md if other med are increasing risk such as antibiotic and immunosuppressants -do not recommended to stop Avoid non absorbent clothing Sodium bicarbonate sits bath
Pharmacologic Treatment of VVC
Imidazole: - butuconazole -clotrimazole -miconazole -tioconazole Available as such vaginal creams, suppositories and tablets Monistat Vaginal Drug Card
Imidazole MOA
Change fungal membrane permeability
Imidazole Treatment
1,3 or seven days
Imidazole ADE
Burning, Itching Irritation
Imidazole DDI
Warfarin
Miconazole
-Check INR
Clotrimazole 1% brand
Gyne-lotrimin 7 cream
Mycelex 7 cream
Clotrimazole 1% cream
Clotrimazole 100 mg tablets
Brand
Mycelex-7 combination pack
Clotrimazole 1% cream dose
Insert cream into vagina Daily for seven days
apply cream to Vulva devise daily for itching
Clotrimazole 1% tablet dosage
Insert tablet into vaginal daily for seven days
Clotrimazole 2% Brand
Gyne-lotrimin 3 cream
Clotrimazole 2% dosage
Insert Cream into vaginal daily for three days
Apply to Vulva twice daily for itching
Butoconasole nitrate 2% brand
Gynazole I
Tioconazole 6.5% brand
Vagistat -1 ointment 1 -day ointment
Butoconasole nitrate 2% dosage
Insert cream into vagina daily for one day
Tioconazole 6.5% direction
Insert ointment into vagina daily for 1 day