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PHM 602 > Women's Health > Flashcards

Women's Health Flashcards

1
Q

Parity

A

of deliveries after 20 weeks

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2
Q

Gravida

A

of pregnancies

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3
Q

Abortus

A

of miscarriages/abortions

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4
Q

1st trimester

A

week 1 to end of week 13

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5
Q

2nd trimester

A

week 14 to end of week 26

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6
Q

3rd trimester

A

week 27 until birth

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7
Q

When is day 1 of pregnancy?

A

First day of last menstrual cycle

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8
Q

Main Embryonic Period

A

weeks 5 to 10

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9
Q

Fetal Period

A

weeks 11 to birth

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10
Q

Exposure at week 3-4

A

All or none effect - spontaneous abortion most common

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11
Q

Exposure at week 5-10

A

major congenital anomalies

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12
Q

Exposure at week 11-birth

A

functional defects and minor anomalies

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13
Q

When is organogenesis

A

weeks 5-11

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14
Q

Folic Acid dose for women of reproductive age

A

0.4 - 0.9 mg

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15
Q

Folic Acid dose for women of reproductive age on Anti Epileptic drugs

A

4 mg

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16
Q

Pregnancy Category A

A

controlled studies show no risk

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17
Q

Pregnancy Category B

A

no evidence of risk in humans OR if no human studies, animal studies show no risk

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18
Q

Pregnancy Category C

A

risk cannot be ruled out - no good human studies and animal studies show risk or there are no animal studies

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19
Q

Pregnancy Category D

A

studies have shown fetal risk but benefits could outweigh the risks

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20
Q

Pregnancy Category X

A

studies have shown fetal risk and risks would outweigh benefits

21
Q

What makes for a good drug to cross the placenta?

A

high lipophilicity
MW <500 daltons
unbound (low protein binding) – switches as pregnancy progresses
weak bases

22
Q

Hypertension medications in pregnancy

A

Labetalol, Nifedipine, Methyldopa

23
Q

N/V treatment in pregnancy

A

Doxylamine + B6
Metoclopramide
Ondansetron

24
Q

Labor Induction using

A

prostaglandins or oxytocin

25
Q

Infant suckling causes release of what?

A

prolactin and oxytocin

26
Q

Prolactin

A

causes alveoli to take nutrients from the blood and turn them into breast milk

27
Q

Oxytocin in lactation

A

causes the cells around the alveoli to contract and eject milk down the milk ducts (let-down)

28
Q

Colostrum

A

first 3 days of breast feeding

29
Q

Mature milk

A

3 - 5 days after birth

30
Q

Foremilk

A

first receives while breast feeding, thin watery

31
Q

Hind-milk

A

released after several minutes of nursing, highest concentration of fat

32
Q

What makes for a good drug to cross into breast milk?

A 
low protein bound
low MW <500 Daltons
High lipid solubility
high concentration
longer half lives
weak bases
33
Q

Safe RID

A

<10%

34
Q

Unsafe RID

A

> 25%

35
Q

RID formula

A 
Infant dose (mg/kg/day)
---------------------------------------
maternal dose (mg/kg/day)
36
Q

Breast milk intake if unknown

A

150 ml/kg

37
Q

Use systemic hormone therapy when…

A

moderate to severe VSM +/- GSM

38
Q

Use intravaginal hormone therapy when…

A

moderate to severe symptoms of GSM

39
Q

Continuous Cyclic HT

A

E daily, P last 12-14 days

Scheduled withdrawal bleed

40
Q

Continuous Combined HT

A

E + P daily

reserved for women 2 years post menopause

41
Q

Continuous Long Cycle HT

A

E daily, P last 12-14 days every other cycle

42
Q

Intermittent Combined HT

A

3 days of E alone then 3 days of E + P

repeat without interruption

43
Q

Testosterone treats

A

decreased sexual desire (no help with VMS)

44
Q

Raloxifene treats

A

OP (worsen VMS)

45
Q

Ospemifene (Osphena) treats

A

severe dyspareunia

46
Q

CEE + Bazedoxifene (Duavee) treats

A

moderate/severe VSM without hysterectomy

47
Q

Paroxetine treats

A

VSM (+depression)

48
Q

Desevelafaxine treats

A

VSM (+depression)

49
Q

Clonidine treats

A

VSM

PHM 602 (3 decks)

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