Wolff Pharm

Question 1

Recombinant forms of RBC growth factor EPO useful for treating anemia due to chronic renal failure or chemotherapy-induced anemia in non-myeloid malignancies (2 drugs)
Which one is longer acting?
What is the major adverse effect?

Answer 1

Epoetin alfa
Darbepoetin alfa - longer-acting
Major adverse effect - hypertension

Question 2

______-fortified foods can obfuscate detection of pernicious anemia

Answer 2

Folate

Question 3

Thrombopoietin agonists indicated for promoting platelet formation in patients with idiopathic thrombocytopenia purpura (2 drugs)

Answer 3

Romiplostim

Eltrombopag

Question 4

What does methionine synthase require to make methionine from homocysteine during folate metabolism in nucleic synthesis?

Answer 4

Vitamin B12

Question 5

Treatment of pernicious anemia requires ______ either parenterally or in very large oral doses

Answer 5

Vitamin B12

Question 6

Myelosuppressive drug that stimulates production of fetal hemoglobin and is used to treat sever cases of sickle cell anemia

Answer 6

Hydroxyurea

Question 7

Drugs that are major causes of aplastic anemia

Answer 7

Cancer chemotherapeutics - alkylating agents, antimetabolites, and cytotoxic antibiotics

Question 8

Iron absorption from the GI tract is regulated by _____

Answer 8

Hepcidin

Question 9

Drugs that are classic causes thrombocytopenia

Answer 9

Quinidine and quinine (anti-malarial)

Question 10

Blocker of CXCR4 receptor (HIV co-receptor) used to reduce hematopoietic stem cell homing to bone marrow as adjunct to facilitate filgrastim mobilization of stem cells to peripheral blood for collection prior to autologous bone marrow transplantation

Answer 10

Plerixafor

Question 11

Lack of vitamin B12 leads to _______ anemia and ______ dysfunction

Answer 11

Megaloblastic; neurologic

Question 12

Recombinant form of GM-CSF which acts in bone marrow to increase production of neutrophils, eosinophils, and monocytes/macrophages
Used to accelerate recovery of myeloid cells after autologous bone marrow transplantation
Adverse effects compared to G-CSF?

Answer 12

Sargramostim

More adverse effects than G-CSF

Question 13

Drugs that are major causes of hemolytic anemia

Answer 13

Cephalosporins (esp. cefotetan and ceftriaxone)

Piperacillin

Question 14

_____ deficiency impairs nucleic acid synthesis to cause megaloblastic anemia without neurological symptoms

Answer 14

Folate

Question 15

Recombinant form of IL-11 and thrombopoietic growth factor that increases platelet levels by promoting formation and maturation of megakaryocytes
Used to treat thrombocytopenia in patients undergoing myelosuppressive chemotherapy for non-myeloid cancers
Adverse effects?

Answer 15

Oprelvekin

Significant adverse effects limit its use

Question 16

Recombinant forms of G-CSF that increase production of granulocytes and are used to:
1. Offset bone marrow suppression caused by cancer chemotherapeutic agents.
2. Mobilize hematopoietic stem cells so they can be harvested from peripheral blood for bone marrow transplantation.
(2 drugs)
Which one is longer-acting?
Adverse effects?

Answer 16

Filgrastim
Pegfilgrastim - longer-acting
Adverse effects - generally well-tolerated but some experience mild to moderate bone pain

Question 17

Why is caution required when treating IDA with oral iron pills?
How do you bypass this?

Answer 17

Oral iron pills can overwhelm hepcidin control

Parenteral iron solutions bypass it

Question 18

Humanized monoclonal antibody that targets complement component C5 to block MAC formation that causes intravascular hemolysis seen with PNH

Answer 18

Eculizumab