Wk2 Models of Psychopathology Flashcards
What are 3 things a model attempts to explain?
Origins of abnormal behaviour Treatment Prevention
What do models provide? 2
Representations of the real world Hypotheses that can be tested.
What are 4 aetiological models?
Genetics Biochemistry Neuroanatomy Endocrine system
What are 4 methods of studying gene-environment interactions?
- Pedigree method 2. Classical twin design 3. Adoption studies 4. Molecular genetics
What is the pedigree method?
Looking at how prevalent disorders are in families.
What is a short coming of the pedigree method?
Hard to disentangle nature vs nurture as genes and experience are shared.
What is a proband?
The first person to have a diagnosis in a family
What are concordance rates?
The rate at which disorders co-occur or are fully absent from twins
When are genetic contributions found in twin studies?
When the MZ are greater than DZ. (100%; 50%)
What are the implications of low and high concordance rates when MZ and DZ rates are equal?
Low - non-shared environment High - shared environmental contributions
What do adoption studies compare?
child’s concordance with biological vs adoptive relatives
What is a candidate gene study?
Is on allele more frequent in people with disorder vs without disorder
The effects of NT systems are ___?
Broad
What does serotonin do?
regulates behaviour, mood and thought processes (feel good)
What is low serotonin associated with?
Aggression Suicide Impulsive overeating Hyper-sexual behaviour
What drugs primarily affect serotonin system?
Tricyclic antidepressants SSRIs (Prozac)
GABA
Gamma Aminobutyric Acid
What does GABA seem to do? 3
Inhibits a variety of behaviours and emotions Anxiolytic effects Reduce overall arousal
How do benzodiazepines work?
Make it easier for GABA to attach to receptors of specialised neurons
What are 2 Noradrenalin circuits in the CNS?
Basic bodily functions (respiration) Emergency reactions
Dopamine and serotonin circuits …
Merge and crossover, influencing many of the same behaviours
What does dopamine mainly do?
Control movements, mood, thought processes
Functions of hindbrain?
Sustaining life, regulation of sleep
Functions of midbrain?
Regulation of some motor activities (fighting and sex), and sleep