Wk 8 Flashcards
Renal artery disease
50 million in US have hypertension.
6% of hypertensive patients have underlying renal disease.
Renal artery disease is the most common correctable cause for hypertension.
Renovascular hypertension and renal artery stenosis
Stenosis or occlusion May cause ischemia.
Triggers Renin-angiotensin mechanism to increase BP and flow to kidney.
Stenosis leads to parenchymal damage.
Renal artery stenosis
Asymptotic “incidental RAS”
Renovascular hypertension.
Ischemic nephropathy.
Accelerated CV disease.
Stenosis of renal artery process
Releases renin, then to angiotensinogen, then to angiotensinogen 1, then to angiotensinogen 2.
Angiotensinogen is natural in body but kidney releases more since it thought the body was hypertensive
Patient clinical history
Hypertension Abnormal urinalysis Hematuria CHF Renal failure Flash pulmonary edema
Renal artery variants
Duplicate RA and polar accessory RA in 12-22%.
Most arose below RA and terminate at polar surface.
Accessory RA can arise from aorta or Iliacs.
Occurs more on left.
Renal artery and vein anatomy
RA inferior to SMA.
RRA longer
Arteries are posterior to vein
LRV courses between aorta and SMA.
Renal vasculature pathology
Atherosclerosis FMD Embolism aneurysm AV fistula External compression Vasculitis
Common risk factors
Age Hypertension Hyperlipidemia Smoking Diabetes Family history Race Obesity Coronary artery disease
Exam indications
Sudden onset or worsening symptoms. Elevated BUN. Cystic kidney disease. Atrophic kidney Aneurysm Hypertension in young patients
Transverse orientation
RA comes off around 11 o’clock
LA comes off around 4-5 o’clock.
Renal artery duplex
Follow artery to hilum.
Obtain Doppler in ostium, prox, mid, dist of each artery.
Look for high PSV and disturbed flow.
Turn to lateral decubitus to see vessels better.-measure kidney in long
Diagnostic criteria
Normal PSV 90-120.
PSV and EDV decrease from artery to cortex.
HS RAS is >60%
Renal aortic ratio
PSV RA/PSV aorta
Aorta PSV 80-100.
Normal criteria
Sharp upstroke, low resistance EDV.
PSV<180.
RAR<3.5
Normal <60% criteria
PSV >180
RAR<3.6
> 60% criteria
Stenosis
PSV>180
RAR>3.5
Post stenotic turbulence
Rena artery occlusion
No signal
If flow, <10
Kidney size 8-9cm
FMD
Non atherosclerotic Typically in young females. Mid distal segments Affects ICA mid dist segments too String of beads
Nutcracker syndrome
Compression of LRV as passes SMA and aorta.
Increased PSV at compression.
May be asymptotic
Treatment options
Anti-hypertension meds
Surgery
Stent, angioplasty
Diuretics
Increase urine to remove water and sodium
ACE inhibitors
Angiotensin converting enzyme.
Angiotensin causes vessels to constrict. ACE stops angiotensin from releasing and dilated vessels.
Beta blockers
Bind to receptors in the heart.
Construct vessels and raises BP
Calvin channel blockers
Slow rate calcium passes into heart muscle and into vessel walls.
Relaxes vessels and lowers BP