Wk 4 - Pharmacokinetics

Question 1

Ke (elimination constant) = ?

Answer 1

Ke = Cl/Vd

Cl = drug clearance
Vd = volume of distribution

Question 2

Vd (volume of distribution) = ?

Answer 2

Vd = total drug/[drug at time 0}

Vd = total drug divided by the concentration of the drug at time zero

Question 3

t1/2 (half-life) = ?

Answer 3

t1/2 = 0.693(Vd/Cl)

Using Ke (elimination constant)
t1/2 = 0.693/Ke

Question 4

Css (steady state plasma concentration) = ?

Answer 4

Css = Ki/Cl

Css = drug input/drug output

Question 5

Maintenance dose = ?

Answer 5

Maintenance dose = (dose rate)(interval)/f

f = bioavailability

Question 6

Loading dose = ?

Answer 6

Loading dose = (Css)(Vd)/f