WK 12- Acid Base and Chest X-ray Flashcards
What is the normal pH value
7.35 – 7.45
What is the normal CO2 value
35-45
What is the normal HC03 value
24-28
What is the base excess
- The base excess is defined as the amount of H+ ions that would be required to return the pH of the blood to 7.35 if the pCO2 were adjusted to normal.
- the excess is positive (above 3) in alkalosis
- the excess is negative (-3) in acidosis
- 3 +3
- bigger the number- more acid:base imbalance
- only tells you about metabolic component (not respiratory)
If you have a low pH and a high PCO2, what is it
respiratory acidosis
What causes the O2 curve to shift to the right
- Right shift, lower SpO2 for a given PaO2
- Increased temperature
- Increased Hydrogen
- Increased CO2
- Increased 2-3-DPG
- Improve oxygen delivery in tissues
What are the 2 ways to acquire acidosis
-2 ways to acquire acidosis
→ too much CO2= lungs are not functioning= respiratory acidosis
→ added to much acid (accumulate H+) to blood/lost bicarb (low HC03)= metabolic acidosis
What are the two ways to acquire alkalosis
→ loss of CO2= respiratory alkalosis
→ accumulate bicarb or loss of H+ (acid)= metabolic alkalosis
- pH= 7.2
- PO2= 80mmg
- PCO2= 60mmHg
- HCO3= 30 mmol/L (low)
-low pH, high PCO2, High HCO2
→ high PCO2 triggers high bicarb to try and neutralise→ therefore has primary resp acidosis with compensatory metabolic alkalosis
-never fully compensate→ pH is still low
→ primary process must be the one in the direction of the pH
What is the anion gap
-represents the difference between the cations (pos) and anions (neg) in blood
-major cations= Na and K
-major anions= Cl and HCO3
=Cations – Anions
→ Na + K – ( HCO3+Cl)
What is the normal anion gap
-normal anion gap should be less than 16
-if above 16= acid is coming from something not normally present in body→ another anion floating around
-if below 16→ acidosis is due to the accumulation of HCL/loss of bicarb
→RAISED ANION GAP INDICATES METABOLIC ACIDOSIS
What causes a raised AG (HAGMA)
Raised AG with 1:1 change in bicarb and AG→ cause by ketoacidosis, lactic acids, urea, salycilate- also the causes of metabolic acidosis
What is a NAGMA
NAGMA: non-anion gap metabolic acidosis
- Bicarb loss/consumption→ diarrhoea
- Acid production
- Endocrinopathies
What causes metabolic acidosis
due to accumulation of H+ or loss of HC03
- H+ is an acid, so will bind to base HC03-> causing loss of HC03
- HCO3 can also be lost in diarrhoea without addition of H+ occuring
- compensated for by resp alklaosis (hypoventilation)
What causes metabolic alkalosis
loss of H+ (ie. in vomit)
-compensation by resp acidosis (increased CO2)= hyperventilation