Winter Final Flashcards
24y/o female. Vaginal spotting. Hx of PID. hcG increased. US shows a suspicious mass in Fallopian tubes. Where in the tube is it most likely located?
Ampulla
Ectopic prego
Female children of women exposed to DES are at an increased risk for what type of cancer?
Vaginal clear cell
Lichen Sclerosis Heterotropism. Which is false?
Never seen in women under 30
Mulluscum contagiosum is associated with
POX virus
You do a vulvar biopsy and find: Bowen’s disease with/mild dysplasia showing VIN1. What is wrong with this diagnosis?
This is a high grade dysplasia –> means there is severe dysplasia
Severe dysplasia = VIN3 (not VIN1)
What is the IHC staining pattern for Paget’s Disease of the Vulva?
CEA+
Cytokeratn +
p53-
S100-
On vulvar biopsy you find: -malignant melanoma with superficial spreading -involved margins Breslow's depth = .67mm Negative ulceration Negative lymphatic invasion
What parts of the IHC staining should be POSITIVE?
B and C are the answer choices-this includes
S100
MART-1
Melanin A
Garner’s duct cyst is composed of what?
Wollfian and Mesonephric Duct Rests
What is true about embryonal rhabdomyosarcoma?
- AKA: Sarcoma botryoides
2. Cambian layer is part of histological features
What is NOT true of squamous cell carcinoma with neuroendocrine features?
CD45 for LCA is not positive
Mild dysplasia CIN1 is….
Low grade intraepithelial lesion
Which is NOT a subtype of squamous cell cancer of the cervix?
Serous papillary
Endometrial cancer Grade 2/3 in the cervix. What is the staining pattern for endometrial cancer?
Vimetin+
CEA-
p16-
ERPR+
Early secretory endometrium (day 17/postovulatory day 3) has which characteristic histologic feature?
Subnuclear vacuoles lined up
Areas of stella phenomenon is associated with…
Ectopic pregnancy
Serous endometrial carcinoma…
is an aggressive tumor associated with intraperitoneal spread
MMMT (Malignant Mixed Mesodermal Tumor) CA….
- is like de-differentiated endometrial CA
- has fuliminant clinical course
Which is TRUE for PT3B Endometrial CA?
Tumor extends into the vagina parametrium
Endometrial Stromal sarcoma. What is the stain?
CD10
Which of the following statements is true of polycystic ovarian disease?
AKA Stein-levanthal syndrome
Pathological report reads 27 yo female with dysfunctional uterine bleeding and endometrial hyperplasia without atypia. Which of the statements is true?
Low grade hyperplastic process initially treated hormonally with progesterone therapy
Pathological report of vaginal biopsy reads clear cell carcinoma grade 3 in a 24 year old female.
Which of the following statements is correct?
Diethylstillbesterol (DES) exposure in the patients mother could be associated with this lesion
WHO staging summary for serous cyst adenocarcinoma confined to the pelvis with positive pleural effusion. Which of the following is true?
Stage 4
Staging summary serous cyst adenocarcinoma. Which of the following is true?
Serous borderline tumors with micro invasion have similar prognosis
Staging summary with mature teratoma prima ovari. What is wrong with the statement?
Not a mature teratoma
Endometrial granulosis cell tumor of the adult type. What is true?
Estrogenic tumor effect
Sex cord stromal tumors with annular tubules…
Associated with Peutz-Jegher Syndrome
Adnexal tumor of Wolffian duct origin. What is true?
Mesonephric origin
Small cell cancer of hypercalcemia type. What is true?
All of the above
Sertoli Leydig cell tumor. What is true?
Masculinizing/androgenizing cell tumor
Mucinous adenocarcinoma of the endometrium. What is true?
Low grade neoplasm
Endodermal sinus tumor. Which of the following is not true?
Is not a seminoma
Ranke’s crystals
Leydig cell tumor
Serous borderline tumors
Low malignant potential
Complete conjoined twins
Monochorionic and monoamniotic
Path report with diagnosis of complete hydatidiform mole
Genotype 46XX
Placental floor infarction
All of the above
TORCH titer
Toxoplasma, syphilis, TB, listeria, rubella, CMV and HSV
Complete mole
occurs in 1/10 pregnancies
Partial mole
triploid
Invasive moles
all of the above
Uterine contents of gestation choriocarcinoma
About 50% occur after molar disease
Chages assocated in placental site trophoblastic tumor
Distinct membranous glomerulonephropathy
Placenta accreta
Complete adherence of decidua to muscle wall
Autopsy with cause of death as placental floor infarction
Misnomer, represents a fibrin deposition, not infarcation
Acute chorioamnioitis and acute funisitis
Ascending fetal infections, Group B Strep and E. coli, associated with premature rupture of membranes, clinical sings are maternal fever
All of the above?
Endometrial hyperplasia without atypia
Low grade and low rate of progression
A biopsy that has endometrial biopsy expected to be day 23 but shows endometrial phasewith glandular and stromal breakdown instead is indicative of what?
Anovulary cycle DUB (Dysfunctional Uterine Bleeding)
What is the endometrial carcinoma staging of cancer that extends outside the uterus but not into true pelvis?
Stage 3
What is true of an adult granulosa cell tumor?
Call-Exner bodies and they are estrogen producing
When the placenta implants over the cervix it is called:
Placenta previa
What HPV strains are associated with caner?
HPV 16
HPV 18
Meconium staining
Sign of fetal distress
Ovarian tumor with capsule of ovary intact:
Stage 1 (a pt1a)
Ovarian tumor with metastasis to capsule (of liver)
stage 3
Ovarian tumor wiht metastasizes to liver parenchyma (through capsule)
stage 4
Serous cystadenocarcinoma of low malignant potential borderline tumor
absence of destructive invasion
Symptoms in malignant surface epithelial tumors:
abdominal pain, increased girth, peritoneal implants and ascities (in ovarian unit)
Ovarian surface tumors of borderline malignant potential:
Peritoneal implants but no destructive invasion, histologiclly malignant but not destructive invasion (low grade malignant)
Mesothelial lesions in the peritoneum
Calretinin+
