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Pathology > Winter Final > Flashcards

Winter Final Flashcards

1
Q

24y/o female. Vaginal spotting. Hx of PID. hcG increased. US shows a suspicious mass in Fallopian tubes. Where in the tube is it most likely located?

A

Ampulla

Ectopic prego

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2
Q

Female children of women exposed to DES are at an increased risk for what type of cancer?

A

Vaginal clear cell

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3
Q

Lichen Sclerosis Heterotropism. Which is false?

A

Never seen in women under 30

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4
Q

Mulluscum contagiosum is associated with

A

POX virus

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5
Q

You do a vulvar biopsy and find: Bowen’s disease with/mild dysplasia showing VIN1. What is wrong with this diagnosis?

A

This is a high grade dysplasia –> means there is severe dysplasia
Severe dysplasia = VIN3 (not VIN1)

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6
Q

What is the IHC staining pattern for Paget’s Disease of the Vulva?

A

CEA+
Cytokeratn +
p53-
S100-

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7
Q 
On vulvar biopsy you find:
-malignant melanoma with superficial spreading
-involved margins
Breslow's depth = .67mm
Negative ulceration
Negative lymphatic invasion

What parts of the IHC staining should be POSITIVE?

A

B and C are the answer choices-this includes

S100
MART-1
Melanin A

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8
Q

Garner’s duct cyst is composed of what?

A

Wollfian and Mesonephric Duct Rests

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9
Q

What is true about embryonal rhabdomyosarcoma?

A
  1. AKA: Sarcoma botryoides

2. Cambian layer is part of histological features

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10
Q

What is NOT true of squamous cell carcinoma with neuroendocrine features?

A

CD45 for LCA is not positive

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11
Q

Mild dysplasia CIN1 is….

A

Low grade intraepithelial lesion

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12
Q

Which is NOT a subtype of squamous cell cancer of the cervix?

A

Serous papillary

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13
Q

Endometrial cancer Grade 2/3 in the cervix. What is the staining pattern for endometrial cancer?

A

Vimetin+
CEA-
p16-
ERPR+

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14
Q

Early secretory endometrium (day 17/postovulatory day 3) has which characteristic histologic feature?

A

Subnuclear vacuoles lined up

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15
Q

Areas of stella phenomenon is associated with…

A

Ectopic pregnancy

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16
Q

Serous endometrial carcinoma…

A

is an aggressive tumor associated with intraperitoneal spread

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17
Q

MMMT (Malignant Mixed Mesodermal Tumor) CA….

A
  • is like de-differentiated endometrial CA

- has fuliminant clinical course

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18
Q

Which is TRUE for PT3B Endometrial CA?

A

Tumor extends into the vagina parametrium

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19
Q

Endometrial Stromal sarcoma. What is the stain?

A

CD10

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20
Q

Which of the following statements is true of polycystic ovarian disease?

A

AKA Stein-levanthal syndrome

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21
Q

Pathological report reads 27 yo female with dysfunctional uterine bleeding and endometrial hyperplasia without atypia. Which of the statements is true?

A

Low grade hyperplastic process initially treated hormonally with progesterone therapy

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22
Q

Pathological report of vaginal biopsy reads clear cell carcinoma grade 3 in a 24 year old female.
Which of the following statements is correct?

A

Diethylstillbesterol (DES) exposure in the patients mother could be associated with this lesion

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23
Q

WHO staging summary for serous cyst adenocarcinoma confined to the pelvis with positive pleural effusion. Which of the following is true?

A

Stage 4

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24
Q

Staging summary serous cyst adenocarcinoma. Which of the following is true?

A

Serous borderline tumors with micro invasion have similar prognosis

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25
Q

Staging summary with mature teratoma prima ovari. What is wrong with the statement?

A

Not a mature teratoma

26
Q

Endometrial granulosis cell tumor of the adult type. What is true?

A

Estrogenic tumor effect

27
Q

Sex cord stromal tumors with annular tubules…

A

Associated with Peutz-Jegher Syndrome

28
Q

Adnexal tumor of Wolffian duct origin. What is true?

A

Mesonephric origin

29
Q

Small cell cancer of hypercalcemia type. What is true?

A

All of the above

30
Q

Sertoli Leydig cell tumor. What is true?

A

Masculinizing/androgenizing cell tumor

31
Q

Mucinous adenocarcinoma of the endometrium. What is true?

A

Low grade neoplasm

32
Q

Endodermal sinus tumor. Which of the following is not true?

A

Is not a seminoma

33
Q

Ranke’s crystals

A

Leydig cell tumor

34
Q

Serous borderline tumors

A

Low malignant potential

35
Q

Complete conjoined twins

A

Monochorionic and monoamniotic

36
Q

Path report with diagnosis of complete hydatidiform mole

A

Genotype 46XX

37
Q

Placental floor infarction

A

All of the above

38
Q

TORCH titer

A

Toxoplasma, syphilis, TB, listeria, rubella, CMV and HSV

39
Q

Complete mole

A

occurs in 1/10 pregnancies

40
Q

Partial mole

A

triploid

41
Q

Invasive moles

A

all of the above

42
Q

Uterine contents of gestation choriocarcinoma

A

About 50% occur after molar disease

43
Q

Chages assocated in placental site trophoblastic tumor

A

Distinct membranous glomerulonephropathy

44
Q

Placenta accreta

A

Complete adherence of decidua to muscle wall

45
Q

Autopsy with cause of death as placental floor infarction

A

Misnomer, represents a fibrin deposition, not infarcation

46
Q

Acute chorioamnioitis and acute funisitis

A

Ascending fetal infections, Group B Strep and E. coli, associated with premature rupture of membranes, clinical sings are maternal fever

All of the above?

47
Q

Endometrial hyperplasia without atypia

A

Low grade and low rate of progression

48
Q

A biopsy that has endometrial biopsy expected to be day 23 but shows endometrial phasewith glandular and stromal breakdown instead is indicative of what?

A

Anovulary cycle DUB (Dysfunctional Uterine Bleeding)

49
Q

What is the endometrial carcinoma staging of cancer that extends outside the uterus but not into true pelvis?

A

Stage 3

50
Q

What is true of an adult granulosa cell tumor?

A

Call-Exner bodies and they are estrogen producing

51
Q

When the placenta implants over the cervix it is called:

A

Placenta previa

52
Q

What HPV strains are associated with caner?

A

HPV 16

HPV 18

53
Q

Meconium staining

A

Sign of fetal distress

54
Q

Ovarian tumor with capsule of ovary intact:

A

Stage 1 (a pt1a)

55
Q

Ovarian tumor with metastasis to capsule (of liver)

A

stage 3

56
Q

Ovarian tumor wiht metastasizes to liver parenchyma (through capsule)

A

stage 4

57
Q

Serous cystadenocarcinoma of low malignant potential borderline tumor

A

absence of destructive invasion

58
Q

Symptoms in malignant surface epithelial tumors:

A

abdominal pain, increased girth, peritoneal implants and ascities (in ovarian unit)

59
Q

Ovarian surface tumors of borderline malignant potential:

A

Peritoneal implants but no destructive invasion, histologiclly malignant but not destructive invasion (low grade malignant)

60
Q

Mesothelial lesions in the peritoneum

A

Calretinin+

Pathology (3 decks)

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