Wills Eye Manual (Most likely on exam) Flashcards

1
Q

Chemical Burn

A

EMERGENCY
1) Copious but gentle irrigation with SALINE or Ringer Lactate solution for at least 30 minutes (Tap water can be used and may be more efficacious

2) Wait 5 to 10 minutes; check pH with litmus paper in the fornices. Continue irrigation until pH level is between 7.0 to 7.4.

Treatment

1) Cycloplegic (Scopolamine 0.25%) ; AVOID PHENYLEPHRINE (VASOCONSTRICTOR)
2) Erythromycin q1-q2h
3) Prednisolone Acetate 1% 4 to 9 times a day

Follow up
Every few days - monitor for corneal epithelial breakdown

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2
Q

Corneal Abrasion

A

Epithelial defect seen with NaFl, Sharp pain with foreign body sensation ; history will tell you if there was any trauma

Treatment
Non-CTL : Ointment of Erythromycin, Bacitraicin or Bacitracin/Polymyxin B (q2-4h) or Oph soln. of Polytrim or FLQ QID. If vegetative use Ciprofloxacin or Moxifloxacin q.i.d.

CTL : Think of Psuedomonas ; FLQ QID and possibly fortified with Tobramycin

Cycloplegic (Cyclopentolate 1% to 2% BID to TID)

Follow up
NON CTL : RTC in 24 hours; if pressure patch, central or large abrasion. If healing happens at the next visit, RTC in 2 to 3 days and then revisit in 3 to 5 days.

CTL : RTC in 1 to 2 days. CTL wear may resume after 1 week after proper course of medication. New CTL should be given at this time.

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3
Q

Corneal and Conjunctival Foreign Bodies

A

History, trauma and no safety glasses used. Look for FB with Desmarres double eversion technique.

B -Scan can be conducted if intraorbital. AVOID MRI.

Treatment
Apply topical Anesthetic. Remove FB with golf club spud. Use Ophthalmic Burr to remove deep, central rust ring.
Ointment of Erythromycin, Bacitraicin or Bacitracin/Polymyxin B (q2-4h) or Oph soln. of Polytrim or FLQ QID. If vegetative use Ciprofloxacin or Moxifloxacin q.i.d.

Follow up
If rust ring remains, 24 hours. Otherwise 2 to 5 days.

If conjunctival FB, then as needed or 1 week for residual FB.

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4
Q

Conjunctival Laceration

A

Inspect entire Sclera below the conjunctival laceration for any perforation. Proparacaine the area to observe and then NaFl, look for siedel sign.

Treatment
Bacitracin or Erythromycin QID

Follow up
1 week if no concomitant ocular damage

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5
Q

Traumatic Iritis

A

Treatment
Cycloplegic (Cyclopentolate 2% TID or Scopolamine 0.25% BID)
Prednisolone Acetate 0.125% to 1% QID

Follow up
5 to 7 days ; if resolved then look into d/c cycloplegic and taper steroid. F/U 1 month for evaluation for angle recession with Gonioscopy and BIO with scleral depression looking for retinal breaks

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6
Q

Hyphema and Microhyphema

A
  • Rule out ruptured globe
  • Measure IOP

Treatment

  • Usually Bedrest; elevate bed to allow blood to settle.
  • Atropine 1% or Scopolomine 0.25% BID to TID
  • AVOID ASPIRIN or NSAID’s
  • Mild Analgesics only
  • Topical steroids (Prednisolone acetate 1% QID to Q1H)

Follow up
Evaluate daily - VA’s, IOP and Slit lamp
few days to 1 week.

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7
Q

Iridodialysis

A
  • Disinsertion of the Iris from the Scleral spur
  • Asymptomatic
  • Unilateral
  • Blunt Trauma

Treatment
Sunglasses, CTL with an artifical pupil or surgery if pt is symptomatic
-If glaucoma develops, start as POAG therapy (Usually AH suppressants)

Follow up
Same as POAG

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8
Q

Cyclodialysis

A

Disinsertion of the CB from the Scleral Spur; this will result in hypotny due to increased uveoscleral outflow

  • Unilateral
  • Trauma

Treatment
Sunglasses, CTL with artificial pupil
-If glaucoma develops, start POAG therapy (Usually AH suppressants)

F/U
Same as POAG

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9
Q

Orbital Blow-Out Fracture

A

Traumatic event, which involves the orbital floor to be damaged. IR is usually involved, with the maxillary sinus.

  • Restricted eye movement
  • Hypoesthesia of ipsilateral cheek
  • Pain on upgaze
  • Local tenderness
  • Eyelid edema
  • Binocular diplopia
  • Recent history of trauma
  • Forced duction testing, only after 1 week of restriction

Management
CT of the orbit and midface

Treatment
1. Broad spectrum oral antibiotics
-Cephalexin 250 to 500mg p.o. QID or
-Erythromycin 250 to 500mg p.o. QID or
-Doxycycline 100mg p.o. BID 
for 7 days
2. DO NOT BLOW NOSE
3. Nasal decongestants
-Oxymetazoline nasal spray BID for 3 days
4. Ice pack for 20 minutes q1-2h for 24 to 48 hours

Follow up
1 to 2 week after trauma

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10
Q

Traumatic Retrobulbar Hemorrhage

A
  • Pain
  • Decreased vision
  • Inability to open the eyelids due to severe swelling
  • Recent history of trauma or surgery
  • Proptosis with resistance to retropulsion
  • Tense eyelids (rock hard)
  • Increased IOP

Treatment
Decompression of the eyelid

Monitor
Until stable - check VA’s and IOP

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11
Q

Traumatic Optic Neuropathy

A

Decreased Visual Acuity VF loss, APD defect and EOM restriction

Treatment
-Same as Retorobulbar Hemorrhage

Follow up
1 to 2 days; Test APD, color vision and Visual Acuity

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12
Q

Intraorbital FB

A
  • Decreased Vision
  • Pain
  • Double vision
  • History of trauma

Deteremine what type of trauma and product

Treatment
DO NOT REMOVE FB
Send to Hospital for surgical removal

Follow up
1 week

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13
Q

Corneal laceration

A
  • Cornea is not perforated
  • Evaluate AC (Shallow AC will display leaking)
  • Positive Siedel sign

Treatment
Cycloplegic (Scopolamine 0.25%)
Antibiotic (Polymyxin B/Bacitracin or FLQ)
Tetanus toxoid for dirty wounds

Follow up
Re-evaluate daily based on epithelial healing

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14
Q

Commotio Retinae

A
  • Asymptomatic; however sometimes decreased vision
  • Trauma (contrecoup)

Signs

  • Confluent area of retinal whitening
  • Berlin’s edema (posterior pole)

Treatment
None

Follow up
DFE in 2 weeks again

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15
Q

Choroidal rupture

A
  • Asymptomatic; however decreased vision
  • Trauma

Signs

  • Yellow or white crescent shaped subretinal streak.
  • Rupture cannot be seen for several days to weeks, due to overlying blood supply.

Treatment
Intravitreal Anti-VEGF therapy; if CNV occurs

Follow up
Re-evaluate in 1 to 2 week

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16
Q

Purtscher Retinopathy

A
  • Decreased vision
  • Compression injury to CHEST or HEAD or Lower extremities but not a direct ocular hit

Signs

  • Multiple Cotton Wool Spots
  • Superficial heme’s around the Optic Nerve
  • Large white retinal superficial region
  • Acute Pancreatitis
  • Malignant HTN
  • Collagen vascular disease

Workup
Systemic work up, if chest injury has not occurred.
-Basic metabolic panel, Amylase, Lipase, CBC, BP and rheumatologic evaluation.
-CT of the head, chest or long bones as indicated

Treatment
None, must treat underlying condition.

Follow up
Repeat DFE in 2 to 4 weeks. VA’s may return to 50% as to before.

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17
Q

Shaken Baby Syndrome/Inflicted childhood Neurotrauma

A

Syndrome of intracranial heme’s, skeletak fractures or multilayered retinal heme’s.

Symptoms

  • Change in mental status
  • New onset of seizures
  • Poor feeding
  • Irritability
  • Inability to track or follow with eyes
  • Child is usually <1 YO and rarely >3 YO
  • Symptoms are often inconsistent with history
Signs
Multilayered (pre, intra and sub retinal) heme's (80%)

Work up
Send to Hospital if Shaken Baby syndrome, to rule out any other damage. Work with Neurosurgery, Pediatric Psychiatry and Social Services

Treatment
Support
Possible vitrectomy, if vitreal heme is noticed

Follow up
Monitor and refer to PCP. 30% mortality rate, survivors can suffer from significant cognitive disabilities and severe loss of vision in 20% of children.

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18
Q

SPK

A

Pain, Photophobia, Red eye, FB sensation and mildly decreased vision.

Pinpoint corneal epithelial defects WITH Staining

Superior Staining = CTL disorder (Chemical toxicity, tight lens syndrome, CTL overwear, GPC)

Vertical epithelial defects = FB under the under the upper eyelid

Inferior staining = Blepharitis, Exposure Keratopathy, Topical drug toxicity, Conjunctivitis, Trichiasis/Distachiasis, Entropion or Ectropion

Treatment
Contact lens wearer = Discontinue CTL, AT’s 6x/day ; if large amounts of SPK then add FLQ
Non CTL wearer = Preservative free AT’s q2h w/ Bacitracin/Polymixin B or Erythromycin ointment QID

NEVER PATCH, AS IT CAN RESULT IN A CORNEAL ULCER.

Follow up
2 to 3 days

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19
Q

Recurrent Corneal Erosion

A
  • Occurs in the morning on awakening
  • Recurrent attacks of acute ocular pain
  • Photophobia
  • FB sensation
  • Tearing

Signs
Localized roughening of the corneal epithelium
NEGATIVE STAINING

Treatment
Cyclopentolate 1% and Erythromycin or Bacitracin QID
-Once defect is clear, start AT’s QID for 3 to 6 months
5% Muro 128 can be given QID for 3 to 6 months.

Follow up
Every 1 to 2 days; until epitelium is healed; every 1 to 3 months.

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20
Q

Filamentary Keratopathy

A

Moderate to severe pain, Red eye, FB sensation, photophobia.

Signs
STRANDS of epithelial cells and mucus attached to the anterior surface of the cornea at one end of the strand.

Most common cause = Dry eye syndrome

Treatment
Treat the underlying condition
Consider debridment of the filaments
Preservative free AT's 6x a day
Punctal occlusion
Acetylcysteine 10% QID (Only available as a compound)

Follow up
1 to 4 weeks

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21
Q

Exposure Keratopathy

A

Irritation, burning, FB sensation and redness of one ro both eyes. Worse in the morning.

Inadequate blinking, leading to dryness in the inferior 1/3 of the cornea

W/U
History of Bell’s palsy, eyelid surgery or Thyroid disease
Assess Bell’s phenomenon
Slit lamp examination

Treatment
Prevention is critical
Preservative AT's q2-6h
Lubricating ointment
Consider eyelid taping

Follow up
1 to 2 day in the presence of corneal ulceration

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22
Q

Pterygium/Pinguecula

A

Irritation, redness, decreased vision but maybe asymptomatic.

Signs
3 to 9 o’clock position at the limbus
Dellen (thinning of adjacent to cornea) and Stocker’s line (Iron deposition)

Treatment

  1. Protect eyes from sun, dust and wind
  2. Lubrication with AT’s 4 to 8 times a day
  3. If Dellen, q2h ointment

Follow up

  1. Asymptomatic - 1 to 2 years
  2. Pterygia - 3 to 12 months
  3. If treating with Steroids then after a few weeks; re-evaluate IOP and ocular inflammation.
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23
Q

Band Keratopathy

A

Decreased vision, FB sensation, corneal whitening and maybe asymptomatic

Signs
Whitening from 3 to 9 o’clock ; usually calcium plaque at the level of Bowman’s

Etiology
Chronic Uveitis, Interstitial Keratitis, Corneal Edema, Repeated trauma and Phthisis bulbi

Treatment
Mild
AT’s 4 to 6/day and AT ointment QHS, Consider bandage contact lens for comfort.

Severe
Removal of Calcium deposit using EDTA

Follow up

  1. Surgery removal - every 1 to 2 days with patching
  2. Pt to be checked every 3 to 12 months on severity of BK.
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24
Q

Bacterial Keratitis

A

Red eye, moderate to severe ocular pain, photophobia, decrease vision, discharge, acute contact lens intolerance

Signs
Focal white opacity (Infiltrate) in the corneal stroma.
-Ulcer exists if there is stromal loss with an overlying epithelial defect that stains with NaFl.

Etiology
Most common - Staphylococcus Pseudomonas> Stretptococcus > Moraxella > Serratia species.

Treatment

  1. FLQ q1h
  2. Do not give steriods; unless its a controlled keratitis
  3. Cyclopegia to reduce PAS

Pain decreasing is usually the first sign if treatment is positive

25
Q

Fungal Keratitis

A

Red eye, moderate to severe ocular pain, photophobia, decrease vision, discharge, usually associated with vegetative trauma, contact lens intolerance.

Signs
Feathery looking ring

Filamentous fungi : Corneal stromal gray-white opacity , usually Fusarium or Aspergillus

Note: B&L had a product recall in 2006, where ReNu MoistureLoc solution has a fusarium outbreak due to CTL wear.

Non-filamentous fungi : Candida species, usually from a previous diseased eye

Treatment
Natamycin 5% drop or Amphoteracin B 0.15% q1h for4 to 6 weeks

Follow up
Daily

26
Q

Acanthamoeba Keratitis

A

Contact Lens and Swimming

Signs
Severe ocular pain, redness, photophobia over a period of several weeks.

Early: Pseudodendrites on the epithelium and considerable amount of pain.

Late: (3 to 8 weeks); Ring shaped corneal stromal infiltrate

Work up
Corneal scraping for Gram, Giemsa and calcofluor white stains

Treatment
1. PHMB 0.02% drops q1h. Clorhexidine 0.02% can be used as an alternative.

  1. Propamidine isethionate 0.1% drops q1h.
  2. Discontinue usage of contact lens in both eyes
  3. Scopolamine 0.25% tid
  4. Oral Steroid for pain or inflammation

Follow up
1 to 4 days until improvement; then 1 to 3 weeks

27
Q

Herpes Simplex Virus

A

Red eye, pain, photophobia, tearing, decreased vision, skin vesicular rash, history of previous episodes, fever blisters; Unilateral

Signs
Eyelid/Skin =Clear vesicles on an erythematous base that progesses into crusting

Conjunctivitis = ACUTE UNILATERAL FOLLICULAR CONJUNCTIVITIS WITH AND WITHOUT DENDRITES

Corneal (Epithelium) = Macropunctate, Dendritic Keratitis (terminal end bulbs on the epithelium) - stain well with Rose Bengal or Lissamine Green, decreased corneal sensitivity

Corneal (Stroma) = Disciform Keratitis (non-necrotizing keratitis - disc shaped stromal edema with an intact epithelium, mild iritis with localized granulomatous keratic perciptates is common, increased IOP. No corneal neovascularization.

                       = Necrotizing Interstitial Keratitis (Uncommon), multiple stromal infiltrates with stromal inflammatory thinning. 

Neurotrophic Ulcer = sterile ulcer with smooth epithelial margins

Workup
Note the vesicle distribution, if the midline is crossed then we are looking at HSV; if not HZV.

Treatment
Epithelial defect (NO STEROIDS FOR EPITHELIAL DEFECT)
Based on HEDS (Herpetic Eye Disease Study);
1. Topical ACYCLOVIR ointment 5x/day (SKIN ONLY); however GANCYCLOVIR 0.15% OPH GEL 5xday.

  1. Warm or cool soaks to skin lesions TID or PRN
  2. If eyelid involved, GANCYCLOVIR 0.15% OPH GEL or TRIFLURIDINE 1% DROPS 5Xday.

Children: Vidarabine 3% ointment 5xday used for 7 to 14 days

IF STROMAL!!!: Topical Steroid ( Prednisolone Acetate 1% QID), GANCYCLOVIR 0.15% OPH GEL 5Xday

Follow up
2 to 7 days to evaluate response to medication and then every 1 to 2 weeks (based on 5 things you evaluate)
a) Size of epithelial defect/ulcer
b) Thickness of corneal involvement
c) Depth of corneal involvement 
d) Anterior Chamber reaction
e) IOP
28
Q

Herpes Zoster Ophthalmicus/Varicella Zoster Virus

A

Dermatomal pain, paresthesias, skin rash or discomfort. Possibly preceded by headache, fever, malaise, blurred vision, eye pain and red eye.

Signs
Acute vesicular dermatomal skin rash, along the 1st division of CN5 (Trigeminal), Unilateral, Hutchinson’s sign (rash on tip of nose) which predicts high chance of ocular involvement, if ocular involvement than usually PSUEDO-DENDRITES seen on the cornea

Work up
a) History; is the pt immunocomprimised (Ie. AIDS/HIV)
b) Complete ocular examination, especially DFE and you would be looking for Progressive Outer Retinal Necrosis (PORN)
c)pt’s under the age of 40; Medical evaluation of HIV
Pt’s 40 to 60 YO = None, unless imunodeficiency is seen
Pt’s >60 YO = If steroids’ are to be given then workup for systemic steroids

Treatment
Vast based on immunocomprimised or not. Look at pages 82 to 84 of Wills Eye Manual. Generally Oral Acyclovir 800mg/ 5xday or Famcyclovir 500mg TID

Follow up
1 to 7 days; depending on severity of ocular complications.

1 to 4 weeks without ocular complications.

Once acute phase has gone, re-check in 3 to 6 months.

29
Q

Intersitial Keratitis

A

Acute symptomatic, occurs in FIRST OR SECOND decade of life.

Signs
Acute = Marked corneal stromal blood vessels and edema, KP’s sometimes on endothelium

Chronic = Deep corneal haze, scarring, corneal stromal blood vessels containing minimal or no no blood vessels, stromal thinning.

Etiology
Most common = Congenital Syphilis, Bilateral or both eyes within 1 year of each other

Common = Acquired Syphilis (Unilateral usually sectoral)
TB (Unilateral, usually sectoral)
Cogan syndrome (Bilateral, Vertigo, Tinnitus, hearing loss, negative syphilis serologies, associated with Vasculitis

Work up

  1. History; Venereal disease during mother’s pregnancy? Difficulty hearing or Tinnitus
  2. Look for Hutchinson’s triad (Saddle nose, teeth and frontal bossing)
  3. SLE and DFE
  4. VDRL, RPR, FTA-ABS and MHA-TP
Treatment
Acute
a)Topical cycloplegia
b)Topical steroid: Prednisolone Acetate 1% q2h
c)Treat underlying condition

Old inactive with central scarring
Corneal transplant to improve vision

Follow up
Acute
3 to 7 days, then 2 to 4 weeks. Steroids to be reduced over months over time and could take upto 2 years.

Old inactive
Yearly follow up

30
Q

Staphylococcal Hypersensitivity

A

Mild photophobia, mild pain, localized red eye, chronic eyelid crusting, FB sensation or dryness. History of recurrent acute episodes, chalazia or styes.

Signs
Singular or multiple, unilateral or bilateral, peripheral corneal stromal infiltrates and the limbus. NO ANTERIOR CHAMBER REACTIONS

Work up

1) History; Recurrent? Contact Lens wearer
2) SLE with NaFl staining and IOP check

Treatment
Mild - Warm compresses, eyelid hygiene and a FLQ antibiotic QID and Bactiracin Ointment qhs

Moderate to Severe
Same as above but add topical steroid (Loteprednol 0.2% to 0.5% or Prednisolone 0.25% qid)

Follow up
2 to 7 days

31
Q

Phlyctenulosis

A

Tearing, irritation, pain, mild to severe photophobia. History of styes or chalazia.

Signs
Conjunctival - small, white nodule on the bulbar conjunctiva, often at the limbus and in the center of hyperemia

Corneal - small, white nodule, initially at the limbus with dilated conjunctival blood vessels approaching it.

Etiology
Delayed Hypersensitivity reaction usually due to Staph or other rare conditions associated with TB

Work up
History; TB?
SLE ; look for anterior blepharitis or rosacea
PPD if no blepharitis or rosacea noted

Treatment
Topical Steroid (Loteprednol 0.5% or Prednisolone Acetate 1% QID
Topical antibiotic if ulcer noted.
Eyelid hygiene
AT’s 4 to 6 times a day
Bacitracin Oph ointment qhs
Doxycycline 100mg po qd ; if rosacea noted

Follow up
Recheck in several days; healing occurs generally 10 to 14 days.

32
Q

Contact lens induced GPC

A

Itching, mucous discharge, decreased lens wearing time, increased lens awareness, excessive lens movement.

Work up
History; Details of CTL use, including age of lenses and wear time
SLE w/ lid eversion

Treatment
Mild to Moderate GPC
1. Replace and refit CTL; Daily lens are preferred
2. If pt wants to use extended, then recommend using Hydrogen-Peroxide cleaner

Severe GPC

  1. Suspend CTL wear
  2. Start with new CTL in 1 to 4 months, preferably dailies
  3. Start Topical Mast cell stabilizer/Antihistamine (Pataday qd)
  4. In unusually severe cases, short term use of low dose topical steroid (Loteprednol 0.2% to 0.5% qid)

Follow up
2 to 4 weeks

33
Q

Peripheral Corneal Thinning/Ulceration

A

Pain, photophobia, red eye; possibly asymptomatic

Peripheral corneal thinning seen with narrow slit beam

Etiology
Connective tissue disease (Rheumatoid Arthritis, Wegener Granulomatosis, Relapsing Polychondritis, Polyarteritis nodsa, Systemic Lupus Erythematosus)

Work up
History; CTL wearer, Inflammatory or connective tissue disease

External examination; Old facial scars (VZV)? Eyelid closure problem causing exposure? Blue tinge to the Sclera? Rosacea Facies

Slit Lamp
Look for infiltrates or corneal ulcer

Schirmer test
Dry eye syndrome

DFE
Look for cotton wool spot consistent with connective tissue disease or evidence of posterior scleritis

Systemic work up

Treatment

  1. Corneal thinning due to connective tissue disease; Management is usually coordinated with rheumatologist or internist
    a) Antibiotic ointment (Erythromycin ointment q2h)
    b) Cycloplegic drops (Scopolamine 0.25%)
    c) Doxycycline 100mg PO BID (due to metalloproteinase inhibition property)
    d) Systemic steroid

Follow up
Severe = Daily
Mild to Moderate =Less frequent

Monitor for any bacterial infection that could occur

34
Q

Dellen

A

Asymptomatic, irritation, FB sensation

Signs
Corneal thinning, usually at the limbus, often in the shape of an ellipse, accompanied by an adjacent focal conjuntival or corneal elevation.

Etiology
Poor spread of tear film over focal area of cornea, which causes stromal dehydration.

Work up
History; Any eye surgery
SLE with NaFl. Look for an adjacent area of elevation.

Treatment

  1. Lubracation or antibiotic ointment every 2 to 4 hours and qhs.
  2. If the cause cannot be removed, like a filtering bleb, lubrication with viscosity done nightly

Follow up
Re-examine 1 to 7 days, unless severe.

35
Q

Keratoconus

A

Progressive decrease vision, usually beginning in adolescence and continuing into middle age. Acute corneal hydrops can cause sudden decrease in vision, pain, red eye, photophobia and profuse tearing.

Signs
Slowly progressive irregular astigmatism resulting from paracentral thinning and bulging of the cornea (Maximal thinning near the apex of protrusion), Vogt Striae - vertical tension lines on the posterior cornea, irregular scissor reflex on retinoscopy, egg-shaped mires on keratometry, Fleisher ring (epithelial iron deposit at the base of cone), Bulging of the lower eyelid when looking downward (Munson’s sign), Corneal hydrops (sudden development of corneal edema) which is due to a rupture in Descemet’s membrane.

Associations
Down syndrome, Turner’s syndrome, Leber congenitial amaurosis, mitral valve prolapse, Retinitis Pigmentosa, Marfan’s syndrome. It is related to chronic eye rubbing and family history is a risk factor.

Differential Diagnosis
Pellucid Marginal Degeneration
Corneal thinning in the INFERIOR periphery; usually 1 to 2 mm from the limbus. The cornea protrudes SUPERIORLY to the band of thinning.

Keratoglobus
Rare, congenital, nonprogressive, uniform circular thinned cornea with maximal thinning in the mid-periphery of the cornea to the area of maximal thinning.

Work up
History; duration and rate of decrease vision? Frequent change in prescription, eye rubbing, medical history, allergies, family history or previous refractive surgery

SLE; look for corneal thinning, vogt straie and fleisher ring (use cobalt blue light)

Retinoscopy
Look for irregular astigmatism

Corneal topography
Central and inferior steepening and Keratometry will display irrregular mires

Treatment

  1. Instruct pt’s not to rub eyes
  2. Correct refractive erros with glasses or soft CTL (in mild cases) or RGP CTL (successful in most cases). Ocassionally hybrid contacts are required.
  3. Partial thickness or full thickness corneal transplantation surgery
  4. Intracorneal ring segments (INTACS)

If corneal hydrops are seen, Cycloplegic agen (Cyclopentolate 1%), Bacitracin ointment qid, briminodine 0.1% bid to tid. Muro 5% ointment BID until resolved

Follow up
Every 3 to 12 months, depending on the progression of symptoms. Hydrops, examine 1 to 4 weeks.

36
Q

Epitheial Basement Membrane Dystrophy

A

Diffuse gray patches (maps), creamy white cysts (dots) or fine refractile lines (fingerprints) in the corneal epithelium.

Best seen with RETROILLUMINATION or broad slit lamp beam angled from the side.

Recurrent corneal erosions may occur, particularyly on opening eye after sleeping.

37
Q

Posterior Polymorphous Dystrophy

A

Change at the level of Descemet membrane, including vesiciles arranged in a linear or grouped pattern.

Iris abnormalities; iridocorneal adhesions and corectopia (decentered pupil) may be present and occasional corneal edema.

Treatment of corneal edema and corneal transplantation for severe cases.

38
Q

Fuch’s endothelial dystrophy

A

Glare, blurred vision, worse upon awakening. May progress to severe pain due to ruptured bullae. Symptoms usually arise after the age of 50.

Signs
Corneal Guttata with stromal edema (Bilateral), fine pigment dusting on the endothelium, central epithelial edema and bullae, folds in descemet membrane, supepithelial haze or scarring.

Work up

  1. History; Previous cataract surgery
  2. SLE; Cornea guttata and best seen with retroillumination. NaFl staining may demostrate shows intact or ruptured bullae.
  3. Measure IOP
  4. Consider specular microscopy to evaluate the endothelial cells and corneal pachymetry to determine the central corneal thickness.

Treatment

  1. Muro 128 5% qid
  2. May gently blow warm air from a hair dryer at arms length toward the eyes for a few minutes every morning to dehydrate the cornea.
  3. IOP reduction if needed
  4. Ruptured corneal bullae are painful and should be treated as RCE
  5. Endothelial keratoplasty such as Descemet Stripping Endotheial Keratoplasty (DSEK), usually needed when corneal edema has caused a sufficient lowering in Visual Acuity.
  6. Penetrating Keratoplasty (PK) is needed if anterior stroma is impacted.

Follow up
Every 3 to 12 months to check IOP and assess corneal edema.

39
Q

Viral Conjunctivitis/Epidemic Keratoconjunctivitis

A

Itching, burning, tearing, gritty or FB sensation. History of recent upper respiratory tract infection or sick contact. Often starts in one eye and involves the fellow eye few days later.

Signs
Inferior palpebral conjunctival follicles, tender palpable preauricular lymph nodes, watery discharge, red and edematous eyelids, pinpoint subconjunctival hemes, punctate keratopathy, Psuedomembrane, microcysts on the cornea, SEI’s develop.

Etiology
Most commonly adenovirus, Pharynconjunctival fever, acute hemorrhagic conjunctivitis.

Treatment

  1. Counsel patient that viral conjunctivitis is self-limited condition that typically gets worse for the 1st 4 to 7 days after the onset and may not resolve 2 to 3 weeks or longer with corneal involvement.
  2. Highly contagious usually for 10 to 12 days of onset, as long as the eyes are red. Pt’s should avoid touching their eyes, shaking hands, sharing towels or pillows etc. Restrict work and school for patients with significant exposure to other while the eyes are red and weeping.
  3. Frequent handwashing.
  4. Preservative free AT’s 4 to 8 times/day for 1 to 3 weeks. Use single tip vials.
  5. Cold compresses multiple times a day
  6. Antihistamine drops, if severe itching.
  7. Peel off membrane.

Follow up
In 2 to 3 weeks, but sooner if the condition worsens significantly or if topical steroids are prescribed

40
Q

Allergic Conjunctivitis

A

Itching, watery discharge, history of allergies and usually bilateral.

Chemosis, red, edematous eyelids, conjunctival papillae and no preauricular nodes.

Treatment
1. Eliminate the inciting agent. Frequent washing of hair and clothes maybe helpful.
2. Cool compresses several times per day
3. Topical drops, depending on severity.
Mild; AT 4 to 8 times/day
Moderate; Pataday BID
Severe; Mild topical steroid (Loteprednol 0.2% qid for 1 to 2 weeks.
4. Oral histamine 25mg po TID

Follow up
2 weeks. Steroids should be tapered.

41
Q

Vernal/Atopic Conjunctivitis

A

Bilateral but possibly asymmetric itiching, thick, ropy discharge, especially in boys. Seasonal (spring/summer) recurrences in vernal, history of atopy in atopic conjunctivitis. Usually seen in younger pts.

Atopy - predisposition to hypersensitivity to an allergen

Signs
Large conjunctival papillae seen under the upper eyelid or along the limbus (limbal vernal)

Superior corneal “shield” ulcer (a well delineated sterile, gray-white infiltrate), limbal raised white dots (horner-tantra dots) of degenerated eosinophils, SPK.

Treatment
1. Treat as allergic except prophylactically use a mast cell stabilizer (lodoxamide 0.1% qid or pemirolast 0.1% qid) for 2 to 3 weeks OR Mast cell stabilizer/Anti-histamine combo (Nedocromil 2% BID, Olopatadine 0.1% BID, Ketotifen 0.025%, bepotastine 1.5% or azelastine 0.05%) for 2 to 3 weeks

  1. If shield ulcer
    - Topical steroid (Loteprednol 0.5% or Prednisolone 1% drops or dexamethsone 0.1% ointment) 4 to 6 times a day.
    - Topical antibiotic (Erythromycin ointment qid, polymixin B/Bacitracin QID)
    - Cycloplegic agent (Scopolamine 0.25%)
  2. Cool compresses qid
  3. Cyclosporine 0.05% to 2% BID to QID. If not responding to the preceeding treatment. Effect not seen for several weeks.
  4. If associated with Atopic dermatitis of eyelids, consider tacrolimus 0.03% to 0.01% qhs or bid (preferred). Topical steroid oph ointment (Fluorometholone 0.1% qid) to the affected skin area.

Follow up
Every 1 to 3 days, in the presence of a shield ulcer; otherwise every few weeks. Topical medication can be tapered. Pts should remain on antiallergy medication through the duration of the season and reinitiated before the next spring.

42
Q

Bacterial Conjunctivitis (Non-Gonoccal)

A

Redness, FB sensation, discharge; itching is much less prominent.

Signs
Purulent white-yellow discharge of mild to moderate degree, conjunctival papillae. NO PREAURICULAR NODE palpation.

Etiology
Staphylococcus Aureus (Associated with blepharitis, phlyctenules and marginal sterile infiltrates. Staph Epidermis, Haemophilus Influenzae (especially in children and commonly associated with otitis media, Streptococcus pneumoniae and Moraxella catarrhalis.

Work up
If severe and re-current or recalcitrant, conjunctival swab for routine culture and sensitivities (blood and chocolate agar) and intermediate Gran stain to evaluate for gonococcus.

Treatment

  1. Topical Antibiotic (Trimethoprim/Polymixin B or FLQ drops QID) for 5 to 7 days.
  2. H. Influenza conjunctivitis should be treated with oral Amoxicillin/Clavulanate (20 to 40mg/kg/day in 3 divided doses) because of occasional extraocular involvement (Eg. Otitis media, pneumonia and meningitis).
  3. If associated with Dacryocystitis (inflammation of lacrimal sac), systemic antibiotics are necessary.

Follow up
2 to 3 days, then every 5 to 7 days until resolved. Antibiotic therapy is adjusted according to culture and sensitivity results.

43
Q

Gonococcal Conjunctivitis

A

Severe purulent discharge , hyper acute onset (within 12 to 24 months), conjunctival papillae, marked chemosis, preauricular adenopathy, eyelid swelling.

Work up

  1. Examine the entire cornea for peripheral ulcers (Especially superiorly) because of the risk of rapid progression to perforation.
  2. Conjunctival scraping for immediate Gram Stain and for culture and sensitivities (eg. Blood agar and chocolate agar)

Treatment
Initiated if the Gram stain shows Gram negative intracellular diplococci or there is a high clinical suspicion of gonococcal conjunctivitis.
1. Ceftriaxone 1g IM single dose. If corneal involvement or cannot be excluded because of chemosis and eyelid swelling, hospitalize the patient and treat with Ceftriaxone 1g IV every 12 to 24 hours. The duration of treatment depends on the clinical response. In penicillin allergic patients, oral FLQ 500 mg po BID for 5 days. Consider consulting an infectious disease specialist. Due to resistance, FLQ’s should not be used to treat gonococcal infections in men who have sex with other men, in areas of high endemic resistance and in patients with a recent foreign travel history. Azithrromycin 1g PO ins sigle dose should be considered.
2. Topical Ciprofloxacin ointment QID or drops q2h. If cornea is involved, then consider FLQ drops q1h (Gati, moxi, besi, levo or cipro -floxacin)
3. Saline irrigation qid until the discharge resolves.
4. Treat for possible chlamydial co-infection (eg. Azithromycin 1g PO single dose or Doxycycline 100mg PO BID for 7 days)
5. Treat sexual partners with oral antibiotics for both gonorrhea and chlamydia as described previously.

Follow up
Daily, until consistent improvement is noted and then every 2 to 3 days until the condition resolves. Partners, should be evaluated by family physician for other STD’s.

44
Q

Pediculosis (Lice, Crabs)

A

Typically develops from contact with pubic lice (usually sexually transmitted). Can be unilateral or bilateral.

Symptoms
Itching, mild conjunctival injection

Signs
Adult lice, nits, and blood tinged debris on the eyelids and eyelashes. Follicular conjunctivitis.

Treatment

  1. Mechanical removal of the lice and eggs with jeweler’s forceps.
  2. Any bland ophthalmic ointment (eg Erythromycin) to the eyelids TID for 10 days to smother the lice and nits.
  3. Antilice lotion and shampoo as directed to nonocular areas for patient and close contacts.
  4. Thoroughly wash and dry all clothes and linens.

NOTE: In children, pediculosis is suspicious for possible sexual abuse and involvement of social services and/or child protection agency is recommended.

45
Q

Chlamydial Conjunctivitis

A

Red eye (conjunctival hyperemia), conjunctival discharge, eyelids sticking (worse in morning), FB sensation, duration >4 weeks.

Sexually transmitted, typically found in young adults. A history of vaginitis, cervicitis, or urethritis may be present.

Signs
Inferior tarsal or bulbar conjunctival follicles, superior corneal pannus, palpable preauricular node or peripheral SEI’s, a stringy mucous discharge may be present.

Workup

  1. History; Determine the duration of red eye, any prior treatment, concomintant vaginitis, cervicitis, or urethritis. Sexually active?
  2. SLE
  3. In adults, direct chlamydial immunofluorescence test, DNA probe, chlamydial culture of conjunctiva, or polymerase chain reaction when available.
  4. Consider conjunctival scraping for giemsa stain: shows basophilic intracytoplasmic inclusion bodies in the epithelial cells, polymorphonuclear leukocytes and lymphocytes in newborns.

Treatment

  1. Azithromycin 1g PO single dose, doxycycline 100mg PO BID or erythromycin 500mg PO QID for 7 days is given to the patient and sexual partners
  2. Topical erythromycin or Tetracycline ointment BID to TID for 2 to 3 weeks.

Follow up
In 2 to 3 weeks, depending on the severity. The patient and sexual partners should be evaluated by their medical doctors for other sexually transmitted diseases. Occasionally a 6 week course of doxycycline may be required.

46
Q

Trachoma

A

Principally occurs in developing countries in areas of poor sanitation and crowded conditions.

Two types of Classification (MacCallan Classification and World Health Organization Classification)

Work up

  1. History of exposure to endemic areas (eg. North Africa, Middle East, India, Southeast Asia)
  2. Examination and diagnostic studies as above (Chlamydial inclusion conjunctivitis).

Treatment
1. Azithromycin 20 mg/kg PO single dose, Doxycycline 100 mg PO BID, Erythromycin 500 mg PO QID or Tetracycline 250mg PO QID for 2 weeks.

  1. Tetracycline, erythromycin or sulfacetamide ointment BID to QID for 3 to 4 weeks.

Follow up
Every 2 to 3 weeks initially, then as needed. Although treatment is usually curative, reinfection is common if hygienic conditions do not improve.

47
Q

Molluscum Contagiosum

A

Dome shaped, usually multiple, umbilicated shiny nodules on the eyelid or eyelid margin.

Follicular conjunctival response from toxic viral products, corneal pannus. Immunocompromised patients may have more lesions and less conjunctival reaction.

Treatment
Removal of lesions by simple excisions, incision and curettage or cryosurgery.

Follow up
Every 2 to 4 weeks, until the conjunctivitis resolves, which often takes 4 to 6 weeks. If many lesions are present, consider human immunodeficiency virus (HIV) testing.

48
Q

Parinaud Oculoglandular Conjunctivitis

A

Red eye, mucopurulent discharge, FB sensation

Granulomatous nodules on the palpebral conjunctiva; visibly swollen ipsilateral preauricular or submandibular lymph nodes.

Fever, rash, follicular conjunctivitis

Etiology
Cat-Scratch disease from Bartonella Henselae (Most common cause): Often a history of being scratched or licked by a kitten within 2 weeks of symptoms.

Work up
Initiated when etiology is unknown (eg. no recent cat scratch)
1. Conjunctival biopsy with scrapping for Gram, Giemsa, and acid fast status.
2. Conjunctival cultures on blood, Lowenstein-Jensen, Sabourd and thioglycolate media.
3. Complete blood count, rapid plasma reagin (RPR), Fluorescent treponemal antibody-absorbed (FTA-ABS), angiotensin converting enzyme (ACE) and if the pt is febrile, blood count.
4. Chest Radiograph, purified protein derivative (PPD) and anergy panel.
5. If Tularemia is suspected, serologic titers are nessecary.
6. If diagnosis, of Cat-Scratch disease is uncertain, cat-scratch serology and cat scratch skin test (Hanger-Rose) can be preformed.

Treatment

  1. Warm compresses for tender lymph nodes
  2. Antipyretics as needed
  3. Disease specific:
    - Cat Scratch disease Generally resolves spontaneously in 6 weeks. Consider azithromycin 500mg PO QID, then 250 mg daily for four doses (for children, 10mg/kg qid) then 5 mg/kg daily for four doses.
    - Tuleremia: Tobramycin 5mg/kg/day in 3 divided doses q8h or gentamicin drops q2h for 1 week.
    - Tuberculosis: Refer to an internist for antituberculosis medication.
    - Syphilis: Systemic penicillin (dose depends on the stage of the syphilis) and topical tetracycline ointment

Follow up
Repeat the ocular examination in 1 to 2 weeks. Conjunctival granulomas and lymphadenopathy can take 4 to 6 week to resolve for cat scratch.

49
Q

Superior Limbic Keratoconjunctivitis

A

Red eye, burning, FB sensation, pain, tearing, mild photophobia, frequent blinking. The course can be chronic with exacerbations and remissions.

Signs
Thickening, inflammation, radial injection of the superior bulbar conjunctiva, especially at the limbus. Fine papillae on the superior palpebral conjunctiva; fine punctate NaFl staining on the superior cornea, limbus and conjunctiva; superior corneal micropannus and filaments. Usually bilateral.

Work up

  1. History: Recurrent episodes? Thyroid disease?
  2. SLE with NaFl staining, particularly of the superior cornea and adjacent conjunctiva. Lift the upper eyelid to see the superior limbal area and then evert to visualize the tarsus. Sometimes the localized hyperiemia is best appreciated by direct inspection by raising the eyeslids of the patient on downgaze,
  3. Thyroid function tests (50% prevalance of the thyroid disease in patients with SLK)

Treatment
Mild
1. Aggressive lubrication with perservative free AT’s four to eight times per day and AT ointment qhs.
2. Consider punctal occlusion with plugs or cautery.
3. Treat any concurrent blepharitis
4. Consider treatment with Cyclosporing 0.05% BID if not responding to lubrication.

Moderate to Severe

  1. Silver Nitrate 0.5% solution applied on a cotton tipped applicator for 10 to 20 seconds to the superior tarsal and superior bulbar conjunctiva after topical anesthesia (eg. Proparacaine). Then irrigation with saline and antibiotic ointment (eg. Erythryomycin) qhs for 1 week.
  2. In the absence of dry eyes, a bandage or daily CTL can be tried.

Follow up
2 to 4 weeks.

50
Q

Subconjunctival Hemorrhage

A

Red eye, usually asymptomatic.

Blood underneath the conjunctiva, often in one sector of the eye. The entire view of the sclera can be obstructed by blood.

Etiology
Valsalva (Coughing, sneezing, constipation or other forms of staining)
Traumatic: Can be isolated or associated with a retrobulbar hemorrhage or ruptured globe.
Hypertension, Bleeding disorder, Antiplatlet or anticoagulant medication (Eg, Aspirin, clopidogrel and warfarin), Hemorrhage due to orbital mass (rare), Idiopathic.

Work up

  1. History.
  2. Ocular examination.
  3. Check blood pressure
  4. Recurrent subconjunctival hemorrhage
  5. If orbital signs are present, preform axial and coronal computer tomographic scanning of the orbits.

Treatment
None required. AT’s drops QID can be given if mild ocular irritation. NSAID’s should be discouraged.

Follow up
Usually. clears spontaneously within 2 to 3 weeks.

51
Q

Episcleritis

A

Acute onsent of redness and mild pain in one or both eyes, typically in young adults; A history of recurrent episodes is common. No discharge.

Signs
Sectoral (and, less commonly, diffuse) redness of one or both eyes, mostly due to engorgement of the episcleral vessels. These vessels are large and run in a radial direction beneath the conjunctiva.

Mild to moderate tenderness over the area of episcleral injection or a nodule that can be moved slightly over the underlying sclera may be seen. NaFl staining can sometimes be seen over the nodule. Associated anterior uveitis and corneal involvement are rare. Vision is normal.

Etiology
Idiopathic: Most common
Infectious: Herpes Zoster virus (scars from an old facial rash may be present, may cause episcleritis or scleritis) and others.
Others: Rosacea, atopy, collagen vascular disease, gout, and thyroid disease.

Work up

  1. History, assess history of rash, arthritis, venereal disease, recent viral illness other medical problems.
  2. External examination in natural light: Look for the bluish hue in scleritis.
  3. SLE: Anesthetize (eg. topical proparacaine) and move the conjunctiva with a cotton tipped applicator to determine the depth of the injected blood vessels. Evaluate for any corneal or anterior chamber involvement. Check IOP.
  4. Place a drop of phenylephrine 2.5% in the affected and re-examine the vascular pattern 10 to 15 minutes later. Episcleral vessels should blanch, highlighting any underlying scleral vascular engorgement.
  5. If the history suggests an underlying etiology, or in cases with multiple recurrences.

Treatment

  1. If mild, treat with AT’s QID
  2. If moderate to severe, a mild topical steroid (FML 0.1%) which relieves the discomfort.
  3. Oral NSAID’s may be used as an alternate steroid-sparing initial therapy (Ibuprofen 200 to 600mg po TID to QID)

Follow up
Patients treated with AT’s need not be seen for several weeks unless discomfort worsens or persists. Re-check every 2 to 3 weeks until symptoms resolve.

52
Q

Scleritis

A

Severe and boring eye pain (most prominent feature), which may radiate to the forehead, brow, or jaw and may awaken the patient at night. Gradual or acute onset with red eye and decrease in vision. Recurrent episodes are common. Scleromalacia perforans may have minimal symptoms.

Signs
Inflammation of scleral, episcleral and conjunctival vessels (scleral vessels are large, deep vessels that cannot be moved with a cotton swab and do not blanch with topical phenylephrine) can be sectoral or diffuse. BLUISH HUE sclera (best seen in natural light by gross inspection). Sceral thinning or edema

Etiology
50% of patients with scleritis have an associated systemic disease. Work up indicated if no known underlying disease is present.

Most common etiology: connective tissue disease (RA, Wegener granulomatosis, relapsing polychondritis, systemic lupus erythematosus, reactive arthritis, ankylosing spondylitis, IBD,gout, herpes zoster, syphillis.

Work up

  1. History: Previous episodes? Medical problems?
  2. Examine in all gazes of the sclera with natural room light.
  3. SLE with red free filter to determine whether avascular areas of the sclera exist.
  4. DFE to rule out posterior scleritis
  5. Physical exam of joints, skin, cardiovascular and respiratory systems by an internist or rheumatologist.
  6. CBC, ESR, Uric acid, RPR, FTA-ABS, RF factor. B scan for posterior scleritis.

Treatment
1. See page 124 of Wills eye for exhaustive list.

53
Q

Blepharitis/Meibomitis

A

Itching, burning, mild pain, FB sensation, tearing and crusting around the eyes on awakening. (Symptoms seem similar to dry eyes but remember that dry eyes get worse at the end of the day)

Crusty, red, thickened eyelid margins with prominent blood vessels or inspissated oil glands at the eyelid margins.

Treatment

  1. Scrub the eyelid margins twice a day with a commercial eyelid scrub or mild shampoo on a wash cloth.
  2. Warm compresses for 10 to 15 minutes BID to QID.
  3. If associated with dry eyes, use artifical tears 4 to 8 times per day
  4. If moderately severe, add erythromycin ointment or azithromycin gel to the eyelids qhs.
  5. Consider cyclosporine 0.05% drops BID especially for meibomitis
  6. Unresponsive meibomitis can be treated with tetracycline 250 mg PO QID or Doxycycline 100mg po QD for 1 to 2 weeks, then taper slowly to 1/4 full dose for 3 to 6 months.

Follow up
3 to 4 weeks.

54
Q

Chalazion/Hordeolum

A

Acute or chronic, eyelid lump, eyelid swelling, tenderness.

Visible or palpable, well defined subcutaneous nodule in the eyelid. In some cases, a nodule cannot be identified.

Chalazion: Area of focal inflammation within the eyelid secondary to the obstruction of a meibomian gland or gland of zeis.

Hordeolum: Acute infection; can be external (stye: abscess of gland of Zeis on lid margin) or internal(absecess of meibomian gland). Usually involves Staphylococcus species and occasionally evolves into preseptal cellulitis.

Work up

  1. History
  2. External examination
  3. SLE; evaluate the meibomian glands inspissation and evert eyelid to rule out other etiologies.

Treatment

  1. Warm compresses for 10 minutes qid with light massage over the lesion.
  2. Consider a topical antibiotic if lesion is draining or for associated blepharitis (Bacitracin or erythromycin ointment BID)
55
Q

Dacryocystitis/Inflammation of the Lacrimal Sac

A

Pain, redness and swelling over the lacrimal sac in the innermost aspect of the lower eyelid. Also tearing, discharge or fever. Symptoms may be recurrent.

Sign
Erythematous, tender, tense swelling over the nasal aspect of the lower eyelid and extending around the periorbital area nasally. Mucoid or purulent discharge can be expressed from the punctum when pressure is applied over the lacrimal sac.

Etiology
Almost always related to nasolacrimal duct obstruction.

Work up

  1. History; previous episodes? Concomitant ear, nose, or throat infection?
  2. External examination: Apply gentle pressure to the lacrimal sac.
  3. Ocular examination: Assess extraocular motility both for proptosis and for other evidence of orbital cellulitis
  4. Obtain a Gram stain and blood agar culture of any discharge expressed from the punctum
  5. Consider CT scan

Treatment
1. Systemic antibiotics in the following regimen.
Children older than 5 Y and <40kg:
-Amoxicillin/Clavulanate 25 to 45 mg/kg PO in 2 divided doses for children, maximum dose 90mg/kg/day
IF SEVERE, HOSPITALIZE AND TREAT WITH 50 TO 100 MG/KG/DAY PO OF CEFUROXINE

Adults
Cephalexin 500 mg PO q6h.
If severely ill start on Hospitalize and Cefazolin 1GIV q8h

  1. Topical: Trimethoprim/Polymixing B QID.
  2. Warm compresses
  3. Acetaminophen for pain
  4. Consider incision and drainage of a pointing abscess

Follow up
Daily until improvement confirmed

56
Q

Preseptal Cellulitis

A

Tenderness, redness and swelling of the eyelid and periorbital area. Often history of sinusitis, local skin abrasions, hordeolum or insect bites. May be a mild fever.

Signs.
Eyelid Erythema, tense edema, warmth tenderness. No proptosis, no optic neuropathy, no restriction of extraocular motility, usually little conjunctival injection and NO PAIN with eye movement (unlike orbital cellulitis). The patient may not be able to open the eye because of the eyelid edema.

Etiology
Adjacent infection

Organisms
S. Aureus and Streptococcus are most common but H. Influenzae should be considered in non-immunized children.

Treatment
1. Antibiotic therapy
Mild and older than 5 YO; Amoxicillin/Clavulanate 25 to 45 mg/kg/day in 2 divided doses for children

If allergic to Penicillin
Trimethoprim/Sulfamethoxazole 8 to 12 mg/kg/day

or

Moxifloxicin 400 mg po daily (contraindicated in children)

If MRSA is suspected; Trimethoprim/sulfamethoxazole 8 to 12 mg/kg/day. Clindamycin 10 to 30 mg/kg/day is good coverage for MRSA and Streptococcus. Doxycycline 100 mg PO BID (contraindicated in pregnant women, children and nursing mothers)

  1. If no improvement in 24 to 48 hours, send to hospital. Vancomycin 10 to 15mg/kg i.v.

Follow up
Daily until clear and consistent improvement is demonstrated, then every 2 to 7 days until condition has totally resolved.

57
Q

Basal Cell Carcinoma

A

Most common malignant eyelid tumor, usually on the lower eyelid or medial canthus of middle aged or elderly patient. Rarely metastasizes but may be locally invasive, particularly when it is present in the medial canthal region. There are 2 forms

a) Nodular: Indurated, firm mass, commonly with telengiectases over the tumor margins. Sometimes the center of the lesion is ulcerated
b) Morpheaform: Firm, flat, subcutaneous lesion with indistinct borders. More difficult to excise and may result in a large eyelid defect.

Treatment
1. Surgical excision with histologic evaluation of the tumor margins either by frozen sections or by Mohs techniques. The entire tumor should be excised with clean margins. Cryotherapy and radiation are used rarely. Topical imiquidmod, an immune modulator, is a newer treatment that might be beneficial but could be toxic to the surface of the eye. Patients are informed about the etiologic role of the sun and are advised to avoid sunlight when possible and to use protective sunscreens.

Follow up
Initial follow up is every 1 to 4 weeks to ensure proper healing of the surgical site. Patients are then re-evaluated every 6 to 12 months or more frequently.

58
Q

Squamous Cell Carcinoma

A

Variable presentation, often appearing similar to a basal cell carcinoma. Regional metastasis may occur and can be extensive with a propensity for perineural invasion. A premalignant lesion, actinic keratosis, may appear as a scaly, erythematous flat lesion or as a cuteneous horn.

Treatment
Surgical excision with histologic evaluation of the tumor margins either by frozen sections or by Mohs techniques. The entire tumor should be excised with clean margins. Cryotherapy and radiation are used rarely. Topical imiquidmod, an immune modulator, is a newer treatment that might be beneficial but could be toxic to the surface of the eye. Patients are informed about the etiologic role of the sun and are advised to avoid sunlight when possible and to use protective sunscreens.

Follow up
Initial follow up is every 1 to 4 weeks to ensure proper healing of the surgical site. Patients are then re-evaluated every 6 to 12 months or more frequently.