White Blood Cells Flashcards
What 3 cells to do Granulocytes refer to and what do the granules do?
Neutrophils, basophils and eosinophils.
The granules are in the cytoplasm and contain agents essential for their phagocytic/microbicidal function.
Monocytes circulate in the blood and are precursors to what?
Macrophages in the tissues.
Monocytes and granulocytes are formed from what?
Myeloblasts
Myeloblasts, Mast cells, Erythrocytes and Megakaryocytes are formed from?
Common Myeloid Progenitor
What are essential for the proliferation and survival of myeloid cells?
Signalling through myeloid growth factors such as G-CSF, M-CSF, GM-CSF.
Cell division in granulocyte maturation occurs in what cells? (3)
What cells does it not take place in? (2)
Takes place in: myeloblasts, promyelocytes and myelocytes
Does not take place in: Metamyelocytes or band forms.
What is granulopoiesis?
Formation and development of granulocytes.
How long does a neutrophil granulocyte survives for how long in the circulation before entering tissues?
7-10 hours
What is special about the nucleus of a mature neutrophil?
The nucleus is segmented (sometimes referred to as lobulated)
What is the main role of neutrophils?
To defend against infection through phagocytosis and then kills micro-organisms
What types of cell can a common lymphoid progenitor differentiate into?
B cells, T cells and Natural Killer cells (Large granular lymphocytes).
What do B cells mature into?
Plasma cells. Plasma cells produce antibodies.
What sort of immunity are T cells involved in?
Cell-mediated immunity.
What are Natural Killer (NK) cells part of and what do they do?
They are part of the innate immune system and they kill tumour cells and virus infected cells.
What are CD4 plus lymphocytes known as? What do they do?
T helper cells. These comprise the majority of the T cell population in the blood. They produce cytokines which activate the monocytes’ macrophage system and promote the synthesis of antibodies by B cells.
