White Blood Cells Flashcards
How to white blood cells maintain themselves?
Stem cell can either renew or diversify (proliferation), generating cells that we need.
What type of cells become more and more restricted in what they can do whilst being developed into a leucocyte?
Progenitors
What are the 5 main types of leucocytes?
Neutrophils Eosinophils Basophils Monocytes Lymphocytes
What is Haemopoiesis?
Production of blood cells and platelets, which occurs in the bone marrow.
Which single cell do spleen cell colonies come from?
Colony Forming Unit-Spleen (CFU-s)
What is the precursor for monocytes called?
Monoblasts
What is the precursor for neutrophils called?
Myeloblasts
What is the precursor for basophils called?
Myeloblasts
What is the precursor for eosinophil called?
Myeloblasts
What is the precursor for lymphocytes called?
Lymphoblasts
What do Neutrophils do?
- part of the body’s non-specific/ innate defences
- first white blood cells to arrive at a site of injury
- specialised in phagocytosing bacteria marked with antibodies
What is the life span of neutrophils?
10 hours in the blood or 30 minutes phagocytosing
What do dead neutrophils form?
Pus
What do Eosinophils do?
- part of the body’s non-specific/ innate defences
- attracted to site of injury
- attack objects coated with antibodies by exocytosis of toxic compounds
- modulate allergic inflammation
What are eosinophils specialised in attacking?
Multicellular parasites
What is the life span of Eosinophils?
10 hours in the blood or 30 minutes phagocytosing
What do Basophils do?
- part of the body’s non-specific/ innate defences
- attracted to site of injury
promote inflammation by releasing histamine to dilate blood vessels and other chemicals to attract other white blood cells
What is the nucleus of neutrophil like?
2-5 lobed nucleus
Are neutrophils easy to stain? and why?
no they are difficult to stain because the cytoplasmic granules are neutral so cannot stain easily with acidic or alkaline dyes
What is the nucleus of an eosinophil like?
2 lobed nucleus
Are eosinophils easy to stain?
yes, they stain strongly with red dye eosin
What is the nucleus of a basophil like?
2 lobed nucleus
Are basophils easy to stain?
yes, they stain strongly with basic dyes
What do monocytes do?
- part of the body’s non-specific/ innate defences
- become phagocytic macrophages at the site of injury - engulfing pathogens and debris
