What is Nuclear Pharmacy and RP Manufacturing

Question 1

RP Manufacturing

Materials used to prepare radiopharmaceuticals used in nuclear pharmacy come from 2 different sources:

Answer 1

• kit formulations
• radiopharmaceutical repackaging

Question 2

RP Manufacturing

kit formulations

Answer 2

requires generators (maufactured), radiopharmaceutical kits (manufactured), and in-house prep

Question 3

RP Manufacturing

radiopharmaceutical repackaging

Answer 3

radiopharmaceuticals repackaged from vial (shipped by manufacturer) into a syringe for ease of administration

Question 4

nuclear pharmacy

The majority of new graduates start work in ___ setting

Answer 4

centralized
* Freestanding lab setting
* no direct patient interaction

Question 5

Facilities – Nuclear Pharmacy

In nuclear practice, pharmacies can be found just about anywhere

Answer 5

• stand alone buildings
• unit in strip mall/shared office space
• in hospital radiology department

Question 6

Facilities – RP Manufacturing

full scale cGMP production facilities

Answer 6

• usually specific type of radiation
• research and development space
• sterility and quality control
• waste handling

Question 7

what are the 2 main locations in a nuclear pharmacy/RP manufacturing facility?

Answer 7

• resricted areas
• non-restricted areas

Question 8

USP 797 is for

Answer 8

non-radioactive compounding

Question 9

USP 825 is for

Answer 9

radioactive compounding

Question 10

all nuclear compunding is done is ___ laminar flow hood

Answer 10

ISO 5

Question 11

2 types of restricted areas

Answer 11

compounding/dispensing and non-dispensing

Question 12

restricted - compounding/dispensing

___ products are prepped and dispensed into unit dose containers

Answer 12

sterile

Question 13

restricted - non-dispensing

non sterile activities carried out here

more people heavy than restricted - compounding/dispensing area

Answer 13

• order entry and verification
• receipt of dispensed unit doses from clean room side of pharmacy
• packaging and shipping of unit doses to end user
• return receipt of delivery materials, returned doses and used doses
• storage and decay of radioactive waste returned to the pharmacy from customers
• processing of incoming shipments of radioactive materials
• use and maintenance of several different types of radiation detection instrumentation

Question 14

non-restricted areas

no radioactivity should be present

Answer 14

kitchen
bathroom
office areas
entry

Question 15

opening shift: first run

Starts: ___ Ends: ___
busiest time of pharmacy - generally ___ or more of doses will be dispensed during this period

Answer 15

• 11pm-1am
• 5 am-6am
• 80%

Question 16

day shift

starts: ___
ends: ___

Answer 16

5am-9am
5 pm

Question 17

the weekend pharmacist is normally also ___

Answer 17

on call