what Hammon said to know for final (mostly in the prev. exam questions) Flashcards
what med can be given PO that increases BP?
Ephedrine
How is tetracaine made?
Substituting a butyl group for the amine group on the benzene ring of procaine.
Which LA is a weak acid?
Benzocaine
MOA of LA?
bind to sodium channel, block sodium current thereby reducing excitability.
Failure of sodium ion channel permeability to increase slows the rate of depolarization such that threshold potential is not reached and thus an action potential is not propagated.
Do LA alter the resting transmembrane potential or threshold potential?
No, they slow the rate of depolorization of the nerve action potential such that the threshold is not reached.
LA protein binding from greatest to least?
Levobupivacaine bupivacaine robivacaine mepivacaine TETRacaine lidocaine prilocaine Procaine
(chloroprocaine has none)
Which amide undergoes the most rapid metabolism?
prilocaine
