WH Flashcards

1
Q

What is an appropriate measure of FHR variability from baseline?

A

6-25 bpm

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2
Q

Normal baseline FHR?

A

110 - 160 bpm

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3
Q

What are some things that can cause minimal/absent variability in FHR?

A
Acidemia
Fetal sleep
Fetal tachycardia
Meds (narcotics, anesthesia)
Prematurity
Cardiac arrhythmias
Pre-existing neuro injury
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4
Q

Define an accel of FHR.

How frequently should these occur?

A

Rise over baseline of 15+ bpm for at least 15 seconds.

At least two should occur over 20 minute span.

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5
Q

Define recurrent late decels

A

Occur with 50%+ of contractions

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6
Q

Fetal decels that mirror the timing of maternal contractions are likely from what cause?

A

Fetal head compression - these are “early” decels and benign

VEAL CHOP: early = head

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7
Q

Decels that occur without contraction are likely from what cause?

A

Cord compression - these are “variable” decels

VEAL CHOP: variable = cord

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8
Q

Decels that are gradual, lasting 30 seconds to 2 minutes, with the nadir after the peak of contractions are likely from what cause?

A

Placental insufficiency - these are “late” decels and are a concerning finding

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9
Q

When is the fetal yolk sac usually visible?

A

From week 5 until ~week 10-12

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10
Q

When is fetal cardiac activity detectable?

A

Around week 6

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11
Q

When do weekly prenatal visits begin?

A

Week 36

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12
Q

When do bimonthly prenatal visits begin?

A

32 weeks, until 36 when weekly visits begin

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13
Q

When is a GBS swab collected in pregnancy?

A

37 weeks

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14
Q

When is TDAP offered to a pregnant patient?

A

28 weeks

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15
Q

When is a GTT performed on a pregnant patient?

A

28 weeks

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16
Q

Associate types of twinning with timing of embryonic cleavage

A

Early (days 1-3) = di/di
Mid (days 4-8) = mo/di
Late (days 8-13) = mo/mo
Very late (days 13/15) = conjoined

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17
Q

Naegle’s Rule?

A

(LMP) - 3 months + 7 days

18
Q

What does a risk of Down’s look like on quad screen?

A

Low estriol, low AFP

High inhibin A

19
Q

What quad screen finding is associated with higher risk of neural tube defects?

A

High AFP

20
Q

If AFP, estriol, and BHcg and high and inhibin A is low on quad screen, what is this concerning for?

A

Trisomy 18

21
Q

What are the age criteria for primary amenorrhea?

A

14YO w/NO pubertal development or

16 YO w/ pubertal development

22
Q

What are some endocrine causes of primary amenorrhea?

A

HyperGnRH hypogonadism:
ex: Turners - high FSH, loss of oocytes

HypoGnRH hypogonadism:
ex: Kallman’s - low FSH, no small
ex: Sheehan’s: hypopituitarism = low FSH
Chronic illness

EuGnRH hypogonadism: PCOS, congenital adrenal hyperplasia, hyperprolactinemia, hypothyroidism

23
Q

Basic, normal physiologic hormone cascade of menstruation

A

Hypothalamus releases GnRH –>

Pituitary releases FSH, LH –>

FSH/LH stimulates ovaries and uterus:

  • FSH causes follicle to develop
  • LH surge causes rupture of follicle/release of ovum

Estrogen from granulosa cells dominates during follicular phase and builds endometrium

Progesterone from corpus luteum stabilizes the uterine lining and promotes production of “uterine milk”

24
Q

Giant multinucleated cells on Tzank smear - Dx and Tx?

A

HSV, give valcyclovir 1g BID x 10 days

25
Q

Tx for chlamydia

A

Doxy 100 mg PO x 7 days

  • If pregnant, use AZ
  • Consider adding ceftriazone 250mg IM for gonorrhea
26
Q

Tx for gonorrhea

A

Ceftriazone 250mg IM

  • Consider adding doxy 100 mg PO x 7 days for chlamydia
27
Q

HPV screening reccs

A
  • Start at 21 with Pap/reflex
  • Start co-testing at 30
  • Stop at 65 or s/p hyst
28
Q

Tx for chancroid

A

Ceftriaxone 250mg IM

29
Q

Tx for lymphogranuloma venerum

A

Doxy 100mg PO BID x 21 days

30
Q

Tx for PID

A

Outpatient:

  • Ceftrixone 500mg IM
  • Doxy x14 days
  • Consider adding metro for BV coverage

Inpatient:
- Cefoxitin or cefotetan IV
- Doxy IV
Transition to doxy alone PO after 24 hours sustained improvement, and consider adding metro for BV coverage

31
Q

Abx for fever presenting intrapartum with RF for chorio

A
  • Amp + gent if vaginal delivery
  • Amp + gent + clinda if C/S

Tylenol for fever, IVF for tachycardia, cooling blanket if needed

  • If non-ana allergy to PCN, replace amp with cefazolin
  • If ana allergy to PCN, replace amp with clinda or vanc as appropriate
32
Q

What are latency antibiotics and when are they used?

A

Preterm labor (<37 weeks):

  • Amp + erythro IV x 2 days
  • Amox + erythro PO x 5 days
33
Q

What is the normal regimen given to a woman presenting with preterm labor <32 weeks?

A
  • Betamethasone (2 doses, 24 hrs apart)
  • Mg Sulfate
  • PCN (GBS proph)
  • IV fluids
  • Tocolytics if membranes have not ruptured: indomethacin for <48 hours
  • Latency antibiotics (amp + erythro then amox + erythro)
34
Q

Define oligo- and polyhydraminos

A

Oligo: Deepest pocket <2 cm or AFI 5cm or less

Poly: Deepest pocket 8+ cm, or AFI 24cm or more

35
Q

Tx for pyelonephritis in pregnancy

A

Amp + gent, or zosyn (tazo+piperacillin) if severe

Outside of pregnancy, cipro

36
Q

Treatments for p/p hemorrhage 2/2 atony

A

Pitocin!

Add if needed:

  • Misoprostol (ass’d transient hyperthermia)
  • Methylergonovine (methergine) - CIx in HTN
  • Carbaprost/hemabate: CIx in asthma, AE = diarrhea

Tamponade if needed; hyst as last resort

37
Q

Tx for endomyometritis

A

I&D + clinda + gent; add ampicillin if no response in 24 hours; add metro after that if needed

38
Q

Name two meds for urge incontinence, their classes, and some AE

A

Oxybutinin: antimuscarinic, has anti-sludge effects

Mirabegron: B agonist, relaxes the detrusor and can cause HTN. CIx in HTN, ESRD, and liver dz

39
Q

Other than NSAIDs, OCPs and surgery, what are some tx options for endometriosis?

A

GnRH agonists: ex, leuprolide + progesterone. Binds GnRH receptors in pituitary, causes down-regulation of HPG axis via negative feedback. Can cause menopause-like AE.

GnRH blockers: suppresses GnRH release, causing hypoestrogenic state. Dose-dependent AE. Example: elagolix.

40
Q

How do COC pills work?

A

Provide negative FB to HPG axis to cause decrease in FSH, decrease in LH, and inhibit follicle development/ovulation

41
Q

How does letrozole work and what is it used for?

A

Aromatase inhibitor - lowers estrogen, can increase FSH to stimulate ovulation.

Used post breast cx
Used in PCOS to help fertility

42
Q

How does clomiphene work and what is it used for?

A

Causes release of GnRH- blocks and agonizes estrogen receptors. Increases FSH via blockade, stimulating ovulation