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Fall Pharm Block 2 > Weight Loss Drugs > Flashcards

Weight Loss Drugs Flashcards

1
Q

What is the formula to calculate BMI?

A

weight in kg / (height in m)^2

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2
Q

What is the down side of weight loss medications?

A

They are costly and weight gain is common as soon as drug is discontinued. (lifestyle changes required)

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3
Q

What is the mechanism of action of Orlistat?

A

Binds to and inhibits pancreatic lipase preventing the absorption of about 30% of dietary fat. Satiety inc.

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4
Q

How is Orlistat administered?

A

120 mg PO, TID pc (after meals). OTC version available at 60 mg. Short term option (< 1 year admin).

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5
Q

What are adverse effects of Orlistat?

A

GI distress, diarrhea, flatulence, steatorrhea, fecal urgency.

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6
Q

What supplement is often coadministered with Orlistat and why?

A

Vitamin A, D, E, and K supplement bc they are fat soluble vitamins –> orlistat blocks their absorption.

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7
Q

What is the mechanism of action of Phentermine?

A

Sympathomimetic that acts as an appetite suppressant. Similar to methamphetamine.

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8
Q

How is Phentermine administered?

A

For 12 weeks, qom (every other month)

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9
Q

What is an adverse effect of Phentermine?

A

HTN

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10
Q

What is the mechanism of action of Liraglutide?

A

GLP-1 agonist increases insulin secretion and delays gastric emptying promoting satiety.

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11
Q

How is Liraglutide administered?

A

Sc, qd

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12
Q

What is the risk of taking Liraglutide?

A

Increased risk of Thyroid C-cell tumors

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13
Q

What is the mechanism of action of Qsymia?

A

A combination of a sympathomimetic and an antiepileptic that is known to cause weight loss.

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14
Q

How is Qsymia administered?

A

qam (every morning) with complex dosing titration.

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15
Q

What are the adverse effects and warnings associated with Qsymia?

A

dizziness, insomnia, contraindicated in pregnancy.

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16
Q

What is the mechanism of action of Contrave?

A

Combination of an atypical antidepressant that blocks dopamine (reward NT) and a long acting narcotic receptor antagonist that causes weight loss. Combo of drugs synergistically blunt the reward mechanism in the brain.

17
Q

Contrave is used cautiously in which patients and why?

A

Narcotic users: can precipitate withdrawal

Eating disorders: patients are hyponatremic and the narcotic antagonist decreases seizure threshold.

18
Q

List 2 other drugs that are being researched as weight loss drugs.

A

zonisamide: antiepileptic
rimonabant: cannabanoid blocker (cannabanoids increase appetitie -munchies)

Fall Pharm Block 2 (8 decks)

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