weight loss Flashcards
paleolithic figurines
evidence of obesity on prehistory
24,000 BC
Neolithis figurines
“mother goddess” artifacts found in anatolia (modern turkey) and Malta
Ancient Egyptian Munnies
King Ramses III and Queen Inhapy- evidence for weight problems
- describes arterial lesion in 1911
- atheromatpus deposits in aorta of King menephtah in 1909
Greeks and the Romans
model of disease involved humors being out of balance
rebalance with Laxatives and purgatives; run before eating; Hyssop plant, water, vinegar, salt
Obesity moist and cool - balance with dry and warm
Evolutionary Perspective
“Thrifty genes” hypothesis: Efficient energy storage adaptation to famine. Evolution has not caught up with the changes in food availability of modern times
Paleo diet
- main idea: eat like “we used to”
- eat to match our metabolic evolution
- diet focus on unprocessed food
Cushing’s syndrome
-1912
-linked to hormone imbalance: cortisol
-too much glucocorticoids cosumption
Babinski-frohlich syndrome
overweight, hypogonadism
Gross & Pitt-Rivers
-T3 (Triiodothyronine)
-Active form of thyroid hormone
-cell energy consumption
Hyperthyroidism
losing weight, fast HR, abnormal HR, nervousness
Amphetamines
Highly addictive;
OG weight loss drug binge eating disorder
later repurposed for ADHD.
Ephedrine
-discovered asthmatic patient receiving ephedrine, caffeine, phenobarbital lost weight
Aminorex
-Edward John Hurlburt
-wight loss through neurotransmitter
-causes pulmonary hypertension
Phentermine
-activate Adrenergic response
-act as a dopamine reuptaker inhibitor
Fenfluramine
-Appetite suppressant
-toxic
-Cardiac valvulopathy and pulmonary hypertension
-used for epliepsy
-market for weight loss
B-3 Agonists
- Increased thermogenesis in adipose tissue: burn instead of store fat
-potential for overactive bladder
