Weel 4 Pharm Cards

Question 1

Major ADES for Microtubule Inhibitors

Answer 1

Peripheral neuropathy, Myelosuppression

Question 2

Vincristine Mechanism

Answer 2

Binds tubulin monomers –> aggregate formation occurs, which inhibits polymerization.

Question 3

Docetaxel, Paclitaxel Mechanism

Answer 3

Binds beta-tubulin –> inhibits depolymerization of microtubules

Question 4

What phase of the cell cycle do microtubule inhibitors affect?

Answer 4

M phase

Question 5

What organs metabolize microtubule inhibitors, what excretes?

Answer 5

Hepatic metabolism

Biliary excretion

Question 6

Topoisomerase Inhibitors Major ADES

Answer 6

Myelosuppression

Question 7

Topotecan Mechanism and Phase

Answer 7

Binds to/stabilizes transient DNA-topoisomerase I cleavable complex –> inhibits top I actions

S phase specific

Question 8

Etoposide Mechanism and Phase

Answer 8

Forms ternary complex with top II and DNA –> accumulation of DNA breakas

S and G2 specific

Question 9

What organ eliminate Topoisomerase Inhibitors?

Answer 9

Renal elimination

Question 10

Vincristine

Answer 10

Microtubule Inhibitor

Question 11

Docetaxel

Answer 11

Microtubule Inhibitor

Question 12

Paclitaxel

Answer 12

Microtubule Inhibitor

Question 13

Topotecan

Answer 13

Topoisomerase Inhibitor

Question 14

Etoposide

Answer 14

Topoisomerase Inhibitor

Question 15

Methotrexate

Answer 15

Antimetabolite

Question 16

5-FU

Answer 16

Antimetabolite

Question 17

Cytarabine

Answer 17

Antimetabolite