Weekly Questions

Question 1

A structural domain is best described as?

Answer 1

A section of protein structure sufficient to perform a particular physical or chemical task

Question 2

The strong conclusion from Anfinsen’s work on RNaseA was that?

Answer 2

the native conformation of a protein is adopted spontaneously

Question 3

Anfinsen probably chose RNaseA for his experiments instead of say trypsin or chymotrypsin because?

Answer 3

trypsin would digest itself to olgiopeptides under mildly denaturing conditions (slow removal or urea)

Question 4

A polypeptide chain contains two terminals - one carboxyl-terminal (C terminal) and the other amino-terminal (N-terminal). Which of the following is true?

Answer 4

N terminal is represented on the left side and C terminal on the right side

Question 5

The primary structure of fibroin, the principal protein of silk worm fibres consists almost entirely of..?

Answer 5

glycine

Question 6

The ramachandran plot can be used to predict which of the following structure?

Answer 6

Secondary structure

Question 7

Which of the following is false?

1. Collagen is a protein in which the polypeptides are mainly in the alpha-helix conformation
2. Disulfide linkages are important for keratin strucutre
3. Silk fibroin is a protein in which the polypeptide is almost entirely in the ? conformation
4. Alpha-keratin is a protein in which the polypeptides are mainly in the alpha-helix conformation

Answer 7

1. Collagen is a protein in which the polypeptides are mainly in the alpha-helix conformation

Question 8

Which of the following vitamins provides the cofactor for hydroxylation reactions in collagen synthesis?

Answer 8

Vitamin C

Question 9

Which of the following is not a fibrous protein?

1. carbonic anhydrase
2. collagen
3. fibroin
4. keratin

Answer 9

1. carbonic anhydrase

Question 10

Vitamin C is the cofactor required for which enzymatic function crucial to the stability of the structure of collagen?

Answer 10

hydroxylation of Pro and lys residues