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Jack CPD > Week 8 Quiz Highlights > Flashcards

Week 8 Quiz Highlights Flashcards

1
Q

SLE is what type hypersensitivity

A

Type III w/ a potential type II involvement

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2
Q

Who has an eightfold to ninefold increased risk of having SLE

A

First degree relative of people with SLE

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3
Q

What drug increases SLE risk 50%

A

estrogen containing contraception

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4
Q

What 3 general symptoms almost always present at some point in SLE

A

fatigue, fever, and weight loss

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5
Q

Name a couple mucocutaneous symptoms of SLE

A

non-painful oral ulcers, raynauds, alopecia, malar butterfly rash

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6
Q

describe the arthritis in SLE

A

symmetric, non-deforming arthritis of digits, wrists, knees, and MTP

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7
Q

major renal cause of death in SLE

A

active glomerulonephritis

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8
Q

most common CVS problem in SLE

A

pericarditis (mimics MI)

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9
Q

most common respiratory problem in SLE

A

pleurisy

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10
Q

2 CNS disorders in SLE

A

psychosis and seizures (there are more too)

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11
Q

common ophthalmologic problem in SLE

A

keratoconjunctivitis sicca

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12
Q

major lab for SLE

A

ANA (antinuclear antibodies)

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13
Q

autoantibodies in SLE

A

Anti-dsDNA, Anti-histone, Anti-ENA, Anti-SSA, Anti-SSB

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14
Q

11 diagnostic criteria for SLE (need 4)

A

malar rash, discoid lupus, photosensitivity, oral/nasopharyngeal ulcers, non-erosive arthritis, renal disorder, neurologic disorder, serositis, hemat. disorder, positive ANA, immunologic disorder

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15
Q

What is Scleroderma

A

immune activation, vascular damage, and excessive synthesis of extracellular matrix with deposition of increased amounts of structurally normal collagen

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16
Q

3 types of Scleroderma and 1 syndrome

A

localized scleroderma, systemic sclerosis, systemic diffuse sclerosis, and CREST Syndrome

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17
Q

Scleroderma w/ no internal organ involvement

A

localized scleroderma

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18
Q

scleroderma w/ skin thickening distal to elbow or knee

A

systemic sclerosis

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19
Q

Define CREST Syndrome

A

Calcinosis, Raynauds, Esophageal dysfunction, Sclerodactyly, Telangiectasia

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20
Q

Onset of scleroderma

A

fatigue, swollen digits, stiff joints, loss of strength, pain, insomnia, skin discoloration

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21
Q

Leading cause of death in scleroderma

A

respiratory

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22
Q

Major and minor (3) criteria for Dx of scleroderma

A

Major is skin thickening just proximal to MCPs. Minor are sclerodactyly, permanent ischemia changes of fingertips, bibasilar pulmonary fibrosis

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23
Q

Patients with scleroderma or ANA

A

positive usually

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24
Q

Polymyositis is

A

direct T cell mediated muscle injury

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25
Q

Dermatomyositis is

A

immune complex deposition in vessels (B cell)

26
Q

Dermatomyositis is associated with increased risk of

A

malignancy

27
Q

Both dermatomyositis and polymyositis present with

A

symmetric proximal muscle weakness

28
Q

characteristics of dermatomyositis

A

Gottron’s papules, shawl sign, heliotrope periorbital rash, and erythroderma

29
Q

PE for dermatomyositis and polymyositis

A

Gower’s Test +

30
Q

Define polymyalgia rheumatica

A

clinical syndrome characterized by severe aching and stiffness in the neck, shoulder girdle, and pelvic girdle

31
Q

Pain of polymyalgia rheumatica

A

severe pain and stiffness in proximal muscle groups without permanent weakness or atrophy

32
Q

How are the mornings for people with polymyalgia rheumatica

A

marked morning stiffness, difficult to get out of bed

33
Q

Dx criteria for polymyalgia rheumatica

A

aged 50 + years on onset, bilateral aching and morning stiffness of 30+ mins for at least one month, stiffness involves 2/3 areas, EST >/= 40

34
Q

concomitant to polymyalgia rheumatica

A

tendency to Temporal Arteritis (Giant Cell Arteritis)

35
Q

What is polyarteritis nodosa

A

systemic vasculitis characterized by necrotizing inflammatory lesions that affect medium and small muscular arteries, preferentially at vessel bifurcations, resulting in microaneurysm formation, aneurysmal rupture with hemorrhage, thrombosis, and organ ischemia or infarction

36
Q

define mixed connective tissue disease (MCTD)

A

An overlap syndrome that incorporates selected clinical features of systemic lupus erythematosus, scleroderma and polymyositis with the presence of the distinctive antibody U1-ribonucleoprotein (RNP).

37
Q

early Sxs of MCTD

A

general malaise, arthralgias, myalgias, and low grade fever. Raynauds too.

38
Q

most important lab for MCTD

A

Anti-U1-RNP

39
Q

RF and CCP status in MCTD?

A

Mostly +

40
Q

Dx criteria for MCTD

A

Anti-U1-RNP w/ 3/5 of: swollen hands, synovitis, myositis/myalgia, raynauds, acrosclerosis

41
Q

disorders of spondyloarthropathies

A

AS, ReA, PsA, and Enteropathic Spondyloarthritis

42
Q

Spondyloarthropathies generally are linked by

A

HLA-B27 and enthesitis

43
Q

define AS

A

chronic painful and progressive inflammatory arthritis primarily affecting spine and SI joints w/ pain and progressive stiffness

44
Q

IL that causes enthesitis in AS

A

IL-23

45
Q

How’s the morning for AS people?

A

stiffness, it often wakes them up

46
Q

symptoms improve in AS w/

A

moderate physical activity

47
Q

What segment of the spine can be subluxed with AS?

A

antlantoaxial subluxation

48
Q

most common extra-articular manifestation of AS

A

uveitis

49
Q

syndrome that can occur in AS when disease is long standing

A

cauda equina syndrome

50
Q

PE findings in AS

A

reduced spinal ROM, loss of lumbar lordosis, accentuation of thoracic spine, stooped posture, decreased expansion of chest, shuffling gait

51
Q

interesting x ray findings in AS

A

T spine “shiny corners”, “bamboo spine”

52
Q

Dx criteria for AS

A

low back pain/stiffness for more than 3 months that improves with exercise but is not relieved b rest, limitation of lumbar spine motion, limitation of chest expansion

53
Q

4 types of psoriatic arthritis

A

symmetric polyarthropathy, asymmetric oligoarthropathy, arthritis mutilans, spondylitis

54
Q

How’re the hands in Arthritis mutilans?

A

osteolysis w/ opera glass hands deformity

55
Q

Which psoriatic arthritis is associated w/ HLA-B27

A

spondylitis

56
Q

Dx criteria for psoriatic arthritis

A

current psoriasis, history of psoriasis, family history of psoriasis, nail changes/dactylitis, inflammatory musculoskeletal disease

57
Q

define reactive arthritis

A

arthritis that follows an infection

58
Q

typical pattern of reactive arthritis

A

mono- or oligoarticular pattern of arthritis, often involving lower extremities

59
Q

classic reiter’s

A

conjunctivitis, urethritis, arthritis–“cant see, cant pee, cant dance”

60
Q

define enteropathic spondyloarthritis

A

arthritis that accompanies inflammatory bowel disease such as Crohn’s or UC, not associated w/ HLA-B27

61
Q

symptoms of enteropathic spondyloarthritis

A

pauciarticular, asymmetric, non-erosive

62
Q

In enteropathic spondyloarthritis severity correlates w/

A

IBD activity but axial symptoms do NOT correlate w/ IBD activity

Jack CPD (1 decks)

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