Week 7 GP Immunology

Question 1

Th1 (T-helper 1)

Question 1

Types of Antigen presenting cells (AT)

Answer 1

• Dendritic cells
• Monocytes/ macrophages
• B Lymphocytes
• Other cell types: endothelial and epithelial cells

Question 2

Innate Immune system

Answer 2

Immediate response (within first 12 hours)

• Non specific and no memory: recognises common pathogen- associated molecular patterns (PAMPS) and damage associated molecular patterns (DAMPS), has no memory.
• Key components: includes physical barriers (skin/mucous membranes), chemical barriers (stomach acids) and immune cells and proteins (complement, phagocytoes), neutrophils/macrophages, dendritic cells, mast cells, NK cells and ILCs

Question 3

Adaptive immune system

Answer 3

-Delayed response (days to weeks)

-Specific response and memory: more specific response to antigens on pathogens with a target response.

-Forms memory of antigen onces its exposed.

• Key components: B and T lymphocytes, antibodies

Question 4

Primary response

Answer 4

• Occurs first time you get exposed to antigen
• slower response there is usually a lag phase (4-7 days)
  1-2 weeks for immune system to generate sufficient levels of antibodies
• B cells produces IgM (igM are short live) followed by IgG
• limited pool of antibodies that are activates, magnitudes of response is smaller

Question 5

Secondary response

Answer 5

• Exposure to the same antigen ther second tine.