Week 7 - Core

Question 1

Atenolol is a water soluble B-adrenoceptor antagonist removed from the body unchanged by urinary excretion. What change in the pharmakinetics of atenolol would you predict for a patient with reduced renal function?

Answer 1

Increased plasma concentration

Question 2

C3b is produced as a part of the complement cascade. What event follows directly due to this molecule?

Answer 2

Opsonisation

Question 3

Enzyme activity can be affected by temperature, pH, & substrate concentration. Measurements are useful in detecting what?

Answer 3

Liver disease - enzymes levels such as ALT & AST are elevated in liver disease

Question 4

In blood plasma, acidic drugs will primarily bind to which protein?

Answer 4

Albumin

Question 5

What influence will the presence of a competitive antagonist will have on the dose-response curve of an agonist binding to the same receptor?

Answer 5

It will be further from the y axis & have the same maximum value

Question 6

Enzyme activity may be regulated by feedback inhibition, allosteric regulation, gene expression, phosphorylation, & proteolysis. What are the features of allosteric regulation by allosteric enzymes?

Answer 6

May effect the V max of the reaction

Question 7

Which enzyme, found it secretions including tears, is part of the chemical barrier against infection?

Answer 7

Lysozyme

Question 8

What drug target is inhibited by lidocaine in the prevention of dental pain?

Answer 8

Ion channel