week 7 Flashcards
cost vs. retail price of drugs
cost could be $5,700 while retail price is $327,000 making a very small % of patients able to receive the drug
average price of new drug in 2007 vs. now
2007- $2,115
now- $180,000
why is the inflation of drug prices happening
rate of return on investment is far below that which the investor can get elsewhere
what is the cancer drug increase rate per year in the USA
10%
how much does CAR-T therapy cost
$1 million
how much does the most expensive drug in the world cost
$3 million
how much does it take to develop a new drug
$2 billion
how many drugs in clinical trials make it to the market
5-10%
what happens if a company is not sufficiently profitable
- share price slumps
- management fired
- company taken over
- employees fired and assests stripped
why is it important to make drugs that go against different targets?
can avoid drug resistance forming
HIV inhibitors
- responsible for integrating viral DNA into human DNA, to allow for replication
- no human equivalent, so good opportunity for selectivity
combination pills
Addition of non-nucleotide reverse transcriptase inhibitors
failed Alzheimer treatments
- bapineuzumab
- ganterumab
- solanezumab
- crenezumab
- semagecestat
- verubecestat
- aducanumab
annual per patient value
((QUALY gained x WTP threshold) + Cost offsets)/Time on treatment
lecanemab
- FDA approved Alzheimer’s drug shown to moderately slow cognitive decline in early stages of the disease by 27%
