Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Actually FMS > Week 6 antineoplastic agents - basics > Flashcards

Week 6 antineoplastic agents - basics Flashcards

1
Q

What are the five classes of “new” antineoplastic drugs?

A

Protein kinase inhibitors, monoclonal antibodies, checkpoint inhibitors, angiogenesis inhibitors, and proteosome inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What class of antineoplastic agents do imantinib, nilotinib, dasatinib, gefitinib, and erlotinib belong to?

A

Kinase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What class of antineoplastic agents do trastuzumab and bevacizumab belong to?

A

Monoclonal antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What class of antineoplastic agents do ipilimumab and nivolumab belong to?

A

Checkpoint inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What class of antineoplastic agents do thalidomide and lenalidomide belong to?

A

Angiogenesis inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What class of antineoplastic agents do bortezamib and carilzomib belong to?

A

Proteosome inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What class of antineoplastic agents do mechlorethamine, cyclophosphamide, bisulfan, carmustine, and cisplatin belong to?

A

Alkylating agents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What class of antineoplastic agents do actinomycin D, adriamycin/doxorubicin, and bleomycin belong to?

A

Antineoplastic antibiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What class of antineoplastic agents do etoposide and irinotecan belong to?

A

Topoisomerase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What class of antineoplastic agents do methotrexate and 6-mercaptopurine belong to?

A

Purine analogs (antimetabolites)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What class of antineoplastic agents does 5-fluorouracil belong to?

A

Pyrimidine analogs (antimetabolites)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What class of antineoplastic agents do vincristine, vinblastine, paclitaxel, and docetaxel belong to?

A

Mitotic spindle inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What class of antineoplastic agents do tamoxifen, flutamide and leuprolide belong to?

A

Estrogen and androgen agonists/antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What class of antineoplastic agents do anaxtrazole, letrozole, and vorozole belong to?

A

Aromatase inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the general mechanism of antineoplastic kinase inhibitors?

A

Inhibits TK receptors to prevent the induction of cell signaling pathways involved in cell proliferation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the general mechanism of antineoplastic monoclonal antibodies?

A

Targets specific molecules involved in cell proliferation, angiogenesis, and immunosuppressive activity for degradation

17
Q

What is the general mechanism of antineoplastic angiogenesis inhibitors?

A

Inhibit the growth of new blood vessels in tumors

18
Q

What is the general mechanism of antineoplastic proteosome inhibitors?

A

Increases the targeting of proteins for degradation, including those that are being overexpressed in tumor cells and causing uncontrolled cell replication

19
Q

What is the general mechanism of purine and pyrimidime synthesis inhibitors?

A

Inhibit the synthesis of nucleic acids to prevent DNA replication.

20
Q

What is the general mechanism of DNA polymerase inhibitors?

A

Prevents DNA replication

21
Q

What is the general mechanism of inhibitors of DNA function by direct interactions?

A

Cause cross-linking, DNA breaks, or DNA modification that renders it incapable of being replicated

22
Q

What is the general mechanism of aromatase inhibitors?

A

Prevent the synthesis of estrogen

23
Q

What is the general mechanism of steroid related antineoplastic drugs?

A

Prevent the synthesis of estrogen or prevent it from binding to the estrogen receptor

24
Q

What is the general mechanism of mitotic spindle inhibitors?

A

Bind to tubulin to produce metaphase arrest

Actually FMS (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions