Week 5: Ventilation/Perfusion

Question 1

ACE-inhibitors

Answer 1

Lisinopril, Zestril, Prinivil

Lowers BP by specific inhibition of the angiotensin-converting enzyme (ACE)

Lisinopril decreased peripheral resistance (afterload) and pulmonary vascular resistance. There is improved CO and exercise tolerance

Uses: HTN, alone or with other anti hypertensives, CHF, to improve MI survival

Route: PO

Check BUN, creatinine, GFR

Question 2

ACE-inhibitors contraindications and precautions

Answer 2

Contraindications: history of angioedema r/t treatment with an angiotensin converting enzyme inhibitors, pregnancy (category D), and nursing mothers

Caution: impaired renal function, hyperkalemia, pts on diuretic therapy; autoimmune diseases esp. systemic lupus erythmatous (SLE)

Increase awareness of serum potassium, creatinine, and GFR

Question 3

Ace inhibitors side effects

Answer 3

HA, dizziness, fatigue

Hypotension, chest pain

N/V, diarrhea, anorexia, constipation

Cough (ACE cough), rash, azotemia

Hyperkalemia, increased BUN and creatinine