Week 5: Middle Ear Disorder/Diseases (I) Flashcards
What are the middle ear disorders/diseases discussed in class?
congenital malformations acute otitis media retraction pocket atelectasis otitis media with effusion tympanostomy tube ossicular chain discontinuity
What is a congenital malformation?
a physical defect present in a baby at birth
also called birth defect or congenital anomaly
Congenital malformation is caused by?
genetic factors
non-genetic (prenatal events - during pregnancy)
Both genetic and non-genetic factors of congenital malformation have two groups, which are?
non-syndromic
syndromic
Non-genetic factors of congenital malformation are acquired by?
acquired by prenatal events such as infections, drugs, alcohol, etc.
What are the two types of syndrome under Syndromic of Genetic factors for Congenital malformation?
Treacher Collins syndrome
Crouzon syndrome
Define syndrome
the combination of signs and symptoms which together represent a particular disease or disorder - different parts of the body are affected
What is Treacher Collins Syndrome?
an autosomal dominant hereditary craniofacial malformation (dysostosis) that affects ears, eyelids, cheekbones, and mandible (lower jaw)
What caused Treacher Collins Syndrome?
it is caused by a mutation in the TCOF1 gene located at chromosome 5
Treacher Collins Syndrome causes?
malformed outer and middle ear Conductive hearing loss eyes slant downward notch in the lower cheekbones mandibular hypoplasia (underdeveloped) - shortened jaw cleft palate (in some cases)
What is Crouzon Syndrome?
an autosomal dominant 10 hereditary craniofacial malformation (dysostosis) that affects ears, eyes, jaw and upper lip
What caused Crouzon Syndrome?
it is caused by a mutation in the FGFR2 gene at chromosome
Crouzon Syndrome causes?
malformed outer and middle ear
Conductive hearing loss
bulging eyes and vision problems (eyes do not point in the same direction)
beaked nose
underdeveloped upper jaw, and enlarged mandible (lower jaw)
shortened upper lip
cleft palate (in some cases)
What is Acute Otitis Media?
infection of the mucous membrane lining the middle ear tympanic activity
primarily a disease of childhood, it can occur at any age
Acute Otitis Media is most common when?
fall and winter
Describes how Acute Otitis Media is developed
first, there is an upper respiratory tract infection (nasopharynx)
then bacteria or viruses gain access to the tympanic cavity through the Eustachian tube from the nasopharynx