Week 5 Flashcards
Nalbuphine (Nubain)
Class
Opiod Analgestic
Nalbuphine (Nubain)
Mechanism of Action
Activates opioid receptor in the limbic system of the CNS
Nalbuphine (Nubain)
Indication
moderate to severe acute pain.
Nalbuphine (Nubain)
Contraindications
Head injury or undiagnosed abdominal pain, diarrhea caused
by poisoning, hypovolemia, and hypotension.
Nalbuphine (Nubain)
Drug Interactions
CNS depressants may potentiate the effects.
Nalbuphine (Nubain)
Adult
2 – 5 mg slow IV; may repeat 2 mg doses PRN to a maximum dose of 10 mg.
Nalbuphine (Nubain)
Pediatric
Pediatric Dose
Not Recommended
Nalbuphine (Nubain)
Onset
2-3 minutes
Nalbuphine (Nubain)
Peak Effect
variable
Nalbuphine (Nubain)
Duration
3-6 hours
Nalbuphine (Nubain)
Special Considerations
Use with caution in patients with impaired respiratory function.
May precipitate withdrawal syndromes in narcotic-addicted patients.
Naloxone should be readily available.
Morphine Sulfate
(Astramorph)
Class
Opioid analgesic
Morphine Sulfate
(Astramorph)
Mechanism of Action
Brain
Alleviates pain through CNS action, suppresses fear and anxiety centers of the brain; depresses brain stem respiratory centers,
Morphine Sulfate
(Astramorph)
Indications
Severe CHF, pulmonary edema, chest pain associated with an acute MI, analgesia for moderate to severe acute and chronic pain.
Morphine Sulfate
(Astramorph)
Contraindications
Head injury, exacerbated COPD, depressed respiratory drive, hypotension. Undiagnosed abdominal pain, decreases level of consciousness, suspected hypovolemia, patients who taken MAOIs in the last 14 days.
Morphine Sulfate
(Astramorph)
Drug Interactions
- Potentiates the sedative effects of phenothiazines
- CNS depressant may potentiate the effects of morphine. -MAOIs may cause paradoxical excitation.
Morphine Sulfate
(Astramorph)
Dosage and Administration
Adult
Initial dose: 2 – 5 mg IV (over 1 – 5 minutes). Repeat dose: 2 mg every 2 minutes titrated to effect.
5-15 mg IM based on patients weight
Morphine Sulfate
(Astramorph)
Dosage and Administration
Pediatric
0.1 – 0.2 mg/kg with a maximum dose of 5 mg, IV, IM, IO, or SC.