Week 5 Flashcards

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1
Q

Nalbuphine (Nubain)

Class

A

Opiod Analgestic

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2
Q

Nalbuphine (Nubain)

Mechanism of Action

A

Activates opioid receptor in the limbic system of the CNS

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3
Q

Nalbuphine (Nubain)

Indication

A

moderate to severe acute pain.

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4
Q

Nalbuphine (Nubain)

Contraindications

A

Head injury or undiagnosed abdominal pain, diarrhea caused

by poisoning, hypovolemia, and hypotension.

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5
Q

Nalbuphine (Nubain)

Drug Interactions

A

CNS depressants may potentiate the effects.

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6
Q

Nalbuphine (Nubain)

Adult

A

2 – 5 mg slow IV; may repeat 2 mg doses PRN to a maximum dose of 10 mg.

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7
Q

Nalbuphine (Nubain)

Pediatric

A

Pediatric Dose

Not Recommended

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8
Q

Nalbuphine (Nubain)

Onset

A

2-3 minutes

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9
Q

Nalbuphine (Nubain)

Peak Effect

A

variable

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10
Q

Nalbuphine (Nubain)

Duration

A

3-6 hours

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11
Q

Nalbuphine (Nubain)

Special Considerations

A

Use with caution in patients with impaired respiratory function.
May precipitate withdrawal syndromes in narcotic-addicted patients.
Naloxone should be readily available.

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12
Q

Morphine Sulfate
(Astramorph)
Class

A

Opioid analgesic

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13
Q

Morphine Sulfate
(Astramorph)
Mechanism of Action
Brain

A

Alleviates pain through CNS action, suppresses fear and anxiety centers of the brain; depresses brain stem respiratory centers,

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14
Q

Morphine Sulfate
(Astramorph)
Indications

A

Severe CHF, pulmonary edema, chest pain associated with an acute MI, analgesia for moderate to severe acute and chronic pain.

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15
Q

Morphine Sulfate
(Astramorph)
Contraindications

A

Head injury, exacerbated COPD, depressed respiratory drive, hypotension. Undiagnosed abdominal pain, decreases level of consciousness, suspected hypovolemia, patients who taken MAOIs in the last 14 days.

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16
Q

Morphine Sulfate
(Astramorph)
Drug Interactions

A
  • Potentiates the sedative effects of phenothiazines

- CNS depressant may potentiate the effects of morphine. -MAOIs may cause paradoxical excitation.

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17
Q

Morphine Sulfate
(Astramorph)
Dosage and Administration
Adult

A

Initial dose: 2 – 5 mg IV (over 1 – 5 minutes). Repeat dose: 2 mg every 2 minutes titrated to effect.
5-15 mg IM based on patients weight

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18
Q

Morphine Sulfate
(Astramorph)
Dosage and Administration
Pediatric

A

0.1 – 0.2 mg/kg with a maximum dose of 5 mg, IV, IM, IO, or SC.

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19
Q

Morphine Sulfate
(Astramorph)
Onset

A

Onset

Immediate

20
Q

Morphine Sulfate
(Astramorph)
Peak Effect

A

Peak Effect

20 Minutes

21
Q

Morphine Sulfate
(Astramorph)
Duration

A

Duration

2-7 hours

22
Q

Morphine Sulfate
(Astramorph)
Special Considerations

A

Use with caution in the geriatric population and those with COPD, asthma. Vagotonic effect in patients with an acute inferior MI, Naloxone should be readily available.

23
Q

Nitrous Oxide

Class

A

Gaseous analgesic and anesthetic

24
Q

Nitrous Oxide

Mechanism of Action

A

Exact mechanism is unknown; affects central nervous system phospholipids.

25
Q

Nitrous Oxide

Indications

A

Moderate to severe pain, anxiety, apprehension.

26
Q

Nitrous Oxide

Contraindications

A

Impaired level of consciousness, head injury, inability to follow instructions, decompression sickness, undiagnosed abdominal pain or marked distension, bowel obstruction, hypotension, shock, COPD (with history of CO2 retention), and chest trauma with pneumothorax.

27
Q

Nitrous Oxide

Drug Interactions

A

None of Significance

28
Q

Nitrous Oxide
Dosage and Administration
Adult

A

Instruct patient to inhale deeply through demand valve mouthpiece or mask.

29
Q

Nitrous Oxide
Dosage and Administration
Pediatric

A

Instruct patient to inhale deeply through demand valve mouthpiece or mask.

30
Q

Nitrous Oxide

Onset

A

2-5 Minutes

31
Q

Nitrous Oxide

Peak Effect

A

Variable

32
Q

Nitrous Oxide

Duration

A

2-5 Minutes

33
Q

Nitrous Oxide

Special Considerations

A

Increases the risk of spontaneous abortion. Nitrous oxide is ineffective in 20% of the population.

34
Q

Nalbuphine (Nubain)
Mechanism of Action
Chest Pain

A

may be preferred in chest pain in setting of an acute MI as it reduces the myocardial oxygen demand without reducing the BP.

35
Q

Nalbuphine (Nubain)
Mechanism of Action
Properties

A

Agonist and Antagonist

36
Q

Nalbuphine (Nubain)
Mechanism of Action
Analgesic Actions

A

Analgesic similar to morphine on a milligram for milligram basis

37
Q

Morphine Sulfate
(Astramorph)
Mechanism of Action
Heart

A

increases peripheral venous capacitance and decreases venous return, decreases preload and afterload, which decreases myocardial oxygen demand.

38
Q

apnea, cyanosis, dizziness are side adverse reactions of this drug?

A

Nitrous Oxide

39
Q

drowsiness, euphoria, malignant hyperthermia are side adverse reactions of this drug?

A

Nitrous Oxide

40
Q

nausea, vomiting are side adverse reactions of this drugs?

A

Nitrous Oxide, Morphine Sulfate

Astramorph

41
Q

Respiratory depression, hypotension are side adverse reactions of this drug or drugs?

A

Morphine Sulfate

Astramorph), Nalbuphine (Nubain

42
Q

bradycardia, tachycardia, syncope are side adverse reactions of this drug or drugs?

A

Morphine Sulfate

Astramorph

43
Q

facial flushing, euphoria, bronchospasm, and dry mout are side adverse reactions of this drug or drugs?

A

Morphine Sulfate

Astramorph

44
Q

decreased level of consciousness is a side adverse reactions of this drug or drugs?

A

Nalbuphine (Nubain)

45
Q

paradoxical CNS stimulation, CNS depression are side adverse reactions of this drug or drugs?

A

Nalbuphine (Nubain)

46
Q

blurred vision, bradycardia, euphoria, facial flushing are side adverse reactions of this drug or drugs?

A

Nalbuphine (Nubain)