Week 5 Flashcards
Small molecule transmitter is created by:
Enzymes in cell body travel down axon and package neurotransmitter in axon terminal
Peptide transmitters are created:
Neurotransmitter precursor and enzymes are together in dendrites. These both travel down axon. Enzymes modify precursor in axon terminal
Chemical events of synapse:
AP> depol>Ca causes vesicles to fuse> transmitter is released into cleft> NT binds > BT removed via enzyme or reuptake > vesicular membrane is brought back into cell
A vesicle has to blank before being released
Dock
Describe SNARE
Brev and Tag are on vesicle. Tax on membrane binds to brev. Ca binds to tag
What counteracts M gracias
Neostigmine
Quantum content
of vesicles
Quantum size
mV
How does Botox work
Gets rid of snare
ANS uses
Ach or NE
CNS uses
GPCRs
Classic GPCR with alpha s (stimulators)
Signal molecule binds receptor. Gtp replaced GDP in gpcr. Alpha unit is activated and travels to activate adenyl cyclase. ATP comes in to create camp. Camp activated PKA. Phosphorylation is next
How does NE B1 work
Class GPCR
How does Gq work
Excitatory.
Gq activated PLC > IP3 and DAG> IP3 act ca / DAG act PKC and phosph
GABA B
Inhibitor. Release K. Uses Gi. Beta gamma complex binds to open K. Alpha binds and inhibits adenyl cycles e
