Week 4 - Weight Loss Medications Flashcards
Which weight loss drug(s) are associated with a suicide risk in children, adolescents, and young adults?
Naltrexone/Bupropion
What happens if lorcaserin is given with a CYP2D6 substrate?
The serum level of the CYP2D6 substrates can be increased. When both drugs are prescribed the CYP2D6 substrate should be given at a lower dose.
Which weight loss drugs are DEA scheduled drugs?
- Lorcaserin
- Diethylpropion
- Phentermine
What on-going monitoring is needed with long-term use of phentermine?
Assessment of cardiac status
At what BMI level should bariatric surgery be considered?
35 or more
Baseline data for Liraglutide
- HbA1c
- Lipids
- Renal function
Ongoing monitoring/assessment needs for liraglutide
- s/s cholecystitis
- pancreatitis
- depression
- suicidal thoughts
What baseline data is needed for Lorcaserin?
Assessment to rule out valvular disorders and pulmonary hypertension
What are the ongoing monitoring/assessment needs for Locaserin?
CBC with differential for s/s of blood dyscrasias
What patient education is needed with Locaserin?
- Do not become pregnant or breastfeed while on this drug
- DM patients may experience hypoglycemia
- If taking CYP2D6 drugs, that dose may need to be increased
What baseline data is needed for naltrexone/bupropion?
- Blood glucose
- Liver function
- Renal panel
- Mental status
What patient education is needed for naltrexone/bupropion?
- Will inhibit the effectiveness of opioids
- Increased risk of suicidal ideation
- report thoughts or feelings and see provider
What are the ongoing monitoring needs for naltrexone/bupropion?
Periodic liver, kidney and blood glucose levels
Signs and symptoms of:
- depression
- anxiety
- panic attacks
- suicidal ideation
- mania
What baseline data is needed for phentermine?
Cardiac assessment
What ongoing monitoring is needed for phentermine?
Assessment of cardiac status
What is the appropriate method of discontinuing phentermine and/or topiramate?
The dose should be tapered off.
What is the therapeutic effect of topiramate?
Induces as sense of satiety
What patient education is needed for Orlistat?
Can cause hypothyroidism in patients on levothyroxine
- Should be taken 4 hours apart from levothyroxine
Can reduce absorption of fat soluble vitamins
- Take a multivitamin daily with A, D, E and K
- Take 2 hours before or after orlistat
- Can intensify effects of warfarin
