Week 3 - Neuro Diseases / Disorders Flashcards
Graves disease (hyperthyroid)
eyes bulging out of head
Horner Syndrome
sympathetic superior cervical ganglion compressed, miosis (constricted pupil), ptosis (drooping eyelid), anhidrosis (no sweat), if present for a long time there will be less pigment in effected iris/eye
Cranial Nerve III palsy / compression
always associated with ptosis (drooping of eyelid), nonreactive pupil to light (will not constrict), and/or extraocular muscle palsy - often caused by vascular problems like aneurysms
Adie’s Tonic pupil
benign lesion of ciliary ganglion, young women, pupil reacts slightly to light and slowly to convergence - pupil nonreactive to light
pharmacological
pupil nonreactive to light, mydriatics (pupil dilators), scopalamine patch, farm chemicals, sympathetic stimulators (pseudoephedrine)
trauma
can cause pupil unreactive to light
physiologic
1mm difference is pupil dilation in light and dark is found in 20% of people
nonreactive pupil to light
dilated pupil, will not constrict
drugs, narcotics
cause constricted pupil - miotics (pupil constrictors)
Argyll Robertson Pupil
constricts poorly to light, but reacts with constriction to convergence, syphilis
iritis
eye pain, redness, anterior chamber inflammation, constricted pupils
Horner’s syndrome - first order neuron disorder
central lesion on hypothalamospinal tract, ex: transection of cervical spinal cord
Horner’s syndrome - second order neuron disorder
most common, preganglionic lesion, ex: compression along sympathetic chain by lung tumor
Horner’s syndrome - third order neuron disorder
postganlionic lesion at level of internal carotid artery, ex: tumor of cavernous sinus or carotid artery dissection
causes of CN III palsy with dilated pupils
vascular disorders (diabetes, heart disease, atherosclerosis, aneurysm of posterior communicating artery), space occupying lesion or tumor, inflammation, infection, physical trauma, demyelinating disease (MS), autoimmune disease (myasthenia gravis), post operative neurosurgery complication, cavernous sinus thrombosis
pupil-sparing CN III palsy
commonly microvascular
pupil-involving CN III palsy
serious / urgent differential
CN III, CN IV, CN V1, CN VI, CN V2, internal carotid artery
pass through cavernous sinus
CN III palsy
down (superior oblique still working) and out (lateral rectus still working) position of affected eye, ptosis (drooped eyelid), mydriasis (pupil dilation)
CN III palsy - parasympathetic fibers
run on outside of nerve (motor on inside of nerve), parasympathetic symptoms before motor symptoms, ptosis (drooping eyelid) and mydriasis (dilated pupil) before down and out eye position
testing CN III function
movement of eye in 6 cardinal fields (H), look for limitation of movement in either eye (-ductions), look for limited gaxe (-versions), nystagmus (uncontrolled movement of the eye), strabismus (ocular misalignment)
causes of isolated ocular muscle weakness / palsy
cranial nerve palsy (VI, IV, III), grave’s disease (hyperthyroid), trauma, giant cell arteritis (inflammation of blood vessels), MS, stroke, mass, myasthenia, sarcoidosis, meningeal infection, meningeal inflammation (lymes) - often adult presenting with double vision
microvascular ocular muscle abnormality
diabetes screen, blood pressure, sed rate for temporal arteritis
thyroid ocular muscle abnormality
weight loss, hair loss, heart palpitations, proptosis, lid lag, red eyes - middle aged with eyes that stick out (proptosis)
neuroimaging ocular muscle abnormality
CT - for muscle size / entrapment / boney abnoramlity / sinus disease; MRI - brain abnormalities / tumors; MRA - angiography for vascular
other causes of ocular muscle abnormality
tensilon test (myasthenia gravis), CBC, lymes, rheumatologic work up (eyes tired with double vision by end of day)
orbital floor fracture
trauma / hydraulic force, fracture in orbital floor/medial orbit, swelling and hemorrhage in orbit affect eye movement, entrapped inferior rectus restricts upward gaze - often shows orbital bone flap with blood in sinus or air in orbit and trapped inferior rectus on CT, Tx surgery (2 wk window) and antibiotics
visual field evaluation
pt sitting in front of you, test eyes individually, pt looks at you, compare their field to yours, if detected - not horizontal or vertical midline - 1/2 or 1/4 of field missing
scotoma
area of abnormal / absent vision within otherwise intact vision field
hemianopia
loss of right or left half of visual field in either eye
homonymous hemianopia
loss of right or left half of vision field in both eyes, lesion on right or left optic tract
bitemporal hemianopia
loss of right half of field in right eye and left half of field in left eye, lesion at optic chiasm
altitudinal defect
loss of superior or inferior half of field
monocular vision loss
lesion on one optic nerve blocking afferent and efferent paths
lower homonymous quadrantopia
lesion on left or right parietal radiation - meyer’s loop
upper homonymous quadrantopia
lesion on left or right temporal radiation
complete vision loss in one eye
compressive tumor, inflammation, neuritis, anterior ischemia, optic neuropathy, vasculitis, idiopathic intracranial hypertension
vision loss in left 1/2 left eye and right 1/2 right eye
parasellar mass - aneurysm, pituitary, adenoma, meningioma, craniopharyngioma
vision loss in left or right halves of both eyes
neoplasm, inflammatory, ischemia, infections - encephalitis, arteriovenous malformation
vision loss in upper right or left quadrant or both eyes
neoplasm, inflammation, ischemia, infection
vision loss in lower right or left quadrant of both eyes
neoplasm, inflammation, ischemia, infection
junctional scotoma (chiasm)
loss of central vision in one eye and temporal field in other eye
visual hallucinations
repeated, formed, faces, animals, people, in color, stereotyped - pt know images aren’t real, elderly, with vision loss, possible early dementia
tunnel vision
loss or peripheral vision, late stage glaucoma, central retinal degeneration, retinal photocoagulation, nonphysiological
retinitis pigmentosa
hereditary degeneration of rods and then cones, bone spicule appearance on retina, restricted to 10-20% of field of vision
panretinal photocoagulation
laser spots, diabetic
examination of optic disc
ophthalmoscope, close to pt, pt looks up, use right eye for right and left eye for left, focus on nerve
optic nerve appearance
disc with central depression (cup), veins - larger / darker, arteries - smaller / lighter
glaucoma
increasing pressure from accumulating aqueous humor, physiologic cup in optic disc gets larger
optic neuritis
vision loss over hours / days, worst in one week, unilateral, 18-45, pain with eye movement, loss of color vision (intensity), decreased light intensity, focal neurological symptoms, flu-like - marcus gunn pupil (RAPD), decreased color vision, visual field defects, swollen disc (1/3 cases) that bulges outward into eye, blurred disc edges
causes of optic neuritis
idiopathic, MS (initial), measles, mumps, chickenpox, mono, zoster, lymes, orbital infection, granulomatous disease (TB, lues, scaroid)
optic neuritis labs
BP, visual field test, sed rate, MRI (shows enlarged optic nerve, inflammed areas on brain - demylination), CBC, RPR, FTA-ABS, CRP
optic neuritis Tx
IV methylprednisolone (1 gm for 3 days) -> oral prednisone (1mg/kg/day for 11 days) -> taper over 4 days -> antiulcer meds, consult
optic neuritis relation to MS
negative MRI = risk of MS low 20% over 10 years - give pulsed IV steroids, pt with 1+ positive MRI spots 50% change of MS over 10 years
ischemic optic neuropathy
sudden, painless, nonprogressive vision loss, over 60, unilateral, RAPD, disc swelling, flame hemorrhages, differentiate between arteritic and non-arteritic -> check sed rate and CRP, headache, jaw claudication, scalp tenderness, joint aches, anorexia, weight loss, fever, biopsy of temporal artery, caused by vascular occlusion
papilledema
optic nerve swelling due to increased intracranial pressure, transient vision loss after rising up, headache, diplopia, nausea, vomiting - optic disc bugles out
bilateral papilledema
intracranial mass, pseudo tumor cerebri, intracranial bleed, hypertensive crisis, hyrocephalus, meningitis
unilateral papilledema
optic neuritis, central retinal vein occulsion, ischemic optic neuropathy, orbital mass, juvenile diabetes, thyroid
spina bifida with meningocele
cyst-like protrusion of dura and arachnoid, detected inutero with ultrasound, failure of caudal end of neural tube to close and induce formation of neural arches in lumbar vertebra
multiple sclerosis
demyelinating disease, decreases axonal transmission due to increased capacitance and loss of saltatory conduction from node to node where Na / K channels are concentrated
closed angle glaucoma
acute, sudden, blockage of aqueous humor outflow
open angle glaucoma
chronic, gradual, overproduction of aqueous humor, more common
hyperopia
far sighted, axial length < focal length = image behind retina, convex lens (+D) correction brings image forward, axial hyperopia = eyeball too short, refractive hyperopia = cornea / lens weak
myopia
near sighted, axial length > focal length, image in front of retina, concave lens (-D) correction pushes image back, axila myopia = eyeball too long, refractive myopia = cornea / lens too strong
presbyopia
aging, decreased malleability of lens -> decreased accommodation, like hyperopia, correct with reading glasses (+D)
astigmatism
uneven lens/cornea, part of visual field out of focus
cataracts
opacity of lens, trauma/radiation/high glucose (diabetes)/age, Tx surgery to replace lens
glaucoma
IOP > 30mmHg, aqueous humor flow problem, loss of vision, 1. cornea with halos, edema, decreased transparency; 2. loss of photoreceptors from periphery to fovea; 3. optic nerve; 4. loss of arterial supply -> necrosis
retinitis pigmentosa
decreased response of photoreceptors, rods first (night blindness), tunnel vision, central color vision, variable age / progression
retinopathy
damage to retina, often from lack of blood supply
vit A deficiency
vit a = retinol (fat soluble vit), affects retinal pigment epithelium, night blindness because rod photopigment can’t be recycled, also immune / bone or skin growth and repair / embryonic development problems
macular degeneration
age, yellow drusen pigments between retinal pigment epithelium and choroid, 2 forms -> dry and wet
dry macular degeneration
atrophy of RPE, loss of photoreceptors, blurry vision, bad night vision, Tx slo with vit A sup, can progress to wet
wet macular degeneration
abnormal growth of blood vessels in choroid, loss of photoreceptors in central vision, Tx angiogenesis inhibitor (anti-VEGF antibodies)
noise induced hearing loss
primarily from damage to hair cells
benign paraphysinal positional vertigo
usually posterior canals of vestibular apparatus effected, can tell which canal and which side, determines therapy given
homonymous defect
visual defect in either right or left visual field, post-chiasmatic defect
heteronymous defect
visual defect of parts of both left and right visual field
hemianopsia
defective vision in 1/2 of a visual field
quadrantanopsia
defective vision in 1/4 of visual field
blindness in right eye
right eye optic nerve
blindness in left eye
left eye optic nerve
bitemporal heteronymous hemianopsia (loss of left and right lateral fields)
lesion on optic chiasm
left homonymous hemianopsia (loss of vision in lateral left and medial right fields)
lesion on right optic tract
left upper homonymous quadrantanopsia (loss of vision in left upper quadrant of both fields)
lesion on lateral right Meyer’s loop
left homonymous hemianopsia with macular sparing (loss of left half of both fields with center spared)
lesion (often of posterior cerebral artery) in medial calcarine cortex, excluding most caudal portion which may have some middle cerebral artery supply
damage anterior to optic chiasm
only affects ipsilateral eye
damage at optic chiasm
produces heteronymous defects because nasal optic fibers can’t cross over
damage posterior to chiasm
produces homonymous defects in visual field opposite to side of lesion
strabismus (squint)
failed coordination of extraocular muscles, deviation of affected eye and diplopia
diplopia
double vision, failure of image to be alinged on same point on each retina
amblyopia (lazy eye)
decreased visual acuity secondary to strabismus, brain avoids diplopia by suppressing vision of one eye in cortex, can occur in kids 3-8, Tx with therapy to train less dominant eye to operate by putting patch over dominant eye
scotoma
island of vision loss, ex: stroke effecting specific part of visual pathway
case - tumor in right visual cortex
loss of left half of visual field, with calcifications on pineal gland and choroid plexus
common causes of red eyes
conjunctivitis (bacterial, viral, allergic), corneal abrasion, foreign body, dry eye
five red eye symptoms that need ophthalmologic consultation
vision change, sluggish pupillary reflex, dendritic corneal lesion (herpes - newborn with HSV mother), pain, vesicular lesions around eye (zoster)
signs of narrow angle glaucoma
diminished / blurred vision, halo, tunnel vision, sudden onset, acute, light shine shows increased ant chamber, globe feels rock hard, KEY - tenometer measures IOP >30mmHg
risk factors of narrow angle glaucoma
40+, African American / Asian / Mexican American, family Hx, diabetes, hypothyroid, heart disease, high BP, other eye conditions, longterm corticosteroid use (esp as eye drops)
viral conjunctivitis
unilateral, tearing, less itch and exudate, possible upper respiratory infection, preauricular adenopathy common, adenovirus common, enterovirus, HSV, zoster
bacterial conjunctivitis
unilateral becoming unilateral, some tear, little itch, lots of purulent discharge, preauricular adenopathy uncommon, pneumococcus common cause, h. inf., staph aureus, N. gonorrhoeae
allergic conjunctivitis
bilateral, itching, tearing, watery
corneal abrasion
can see with blue scope lens and flurosine stain, check under lid for foreign body, heal 24 hours, if large antibiotic drops, no patch unless indicated, trauma, FB sensation, visible FB
foreign body
often under lens, may be imbedded in eye = x-ray, use lid eversion to look
dry eye
feels like foreign body, overuse of antihistamines, common in elderly, check meds, lack of tearing, Tx artificial tears
hyphema
blood in anterior chamber, trauma, need to drain, refer to ophthamologist
iritis
whole eye red, less swelling, abnormal vision, more pain, see ophthamologist
subconjunctival hemorrhage
patch of blood up top of white sclera, looks bad but harmless, common with labor strain / extreme pushing / weight lifting, spontaneous, will reabsorb
tonsilitis
large red palatine tonsils, can be in adults too, usually kids
black hairy tongue
benign, hypertrophy of papillae, smokers
malignant melanoma
dark asymmetrical spot on gums
cancer under tongue
tobacco chewers, hard as a rock
torus / tori
midline bump on palate, smooth, hard as bone, benign
minor salivary gland malignancy
off midline, roof of mouth, firm but spongy, more common than malignancy of larger salivary glands
localized plasmacytoma
lymphoma variant, on gums, fatigue, anemia, Tx radiation
pharyngeal cancer
progressive sore throat
unilateral vocal cord paralysis
poor voice on phonation with over compensation of intact side, good airway on inspiration
bilateral vocal cord paralysis
voice good on phonation because chords are similarly affect, airway poor on inspiration because neither side will spread
vocal cord nodule
benign, hoarseness
vocal cord polyps
swollen vocal cords
vocal cord cancer
warty looking, Tx success is stage dependent, Tx radiation
laryngeal cancer
hoarseness, can cause pain in ears
case - 69, progressive hoarseness, throat pain, no response to antibiotics, neg strep test, smoker, drinker, hemoptysis, dysphagia
vocal cord cancer
pack / years
packs per day x number of years smoked
cancer of the larynx
40+, drinker, smoker, chronic cough, weight loss, ear ache, neck lump, short of breath, hoarse, tickle, pain with swallow, hemoptysis
laryngectomy
removes larynx, preserve plane of platysmal (save nerves/vessels), remove muscles, split thyroid, lay nerves laterally, cut away from pharynx and close pharynx, ***if person with stoma from laryngectomy needs air it must go through stoma - no connection between airway and mouth
case - 57, progressive hoarseness, no meds, healthy, nonsmoker, nondrinker, small paramedian neck mass
invasive thyroid cancer the is compressing recurrent laryngeal nerve to the larynx -> vocal cord paralyzed on one side, thyroid masses are mostly benign, workup -> ultrasound and needle biopsy, in surgical removal must take care to leave parathyroid glands and recurrent laryngeal nerve
case - 42, teacher, past smoker, nondrinker, variable hoarseness
vocal cord nodule, common in singers / speakers / teachers / lawyers, speech therapy, voice hygeine
signs of airway obstruction
stridor, respiratory effort, chest retraction, tracheal tug, intercostal retraction - little positive pressure will help breathing
stridor
laryngeal sound with airway obstruction, high pitch, inspiratory, then inspiratory and expiratory, 90% compromised airway, drop chest and raise abdomen = airway gone
sturdor
upper pharyngeal, gurgling, caused by swollen tonsils, pneumonia
croup
acute infection of larynx, slow onset 24-48 hrs, subglottic inflammation, viral / parainfluenza / RSV, inspiratory stridor, seal bark cough, rarely need intubation, Tx humidified air and steroids, steeple sign on PA film due to extended narrowing of airway below vocal cords
epiglottotis
WBC, blood culture, urine antigens, abrupt onset (hours), endoscopy with intubation, sit upright, hurts to swallow, intercostal and suprasternal retraction, lateral film shows thumbprint sign inflammed epiglotis, Tx antibiotics and intubation
vocal cord nodule
benign, hoarseness
vocal cord polyps
swollen vocal cords
vocal cord cancer
warty looking, Tx success is stage dependent, Tx radiation
laryngeal cancer
hoarseness, can cause pain in ears
case - 69, progressive hoarseness, throat pain, no response to antibiotics, neg strep test, smoker, drinker, hemoptysis, dysphagia
vocal cord cancer
pack / years
packs per day x number of years smoked
cancer of the larynx
40+, drinker, smoker, chronic cough, weight loss, ear ache, neck lump, short of breath, hoarse, tickle, pain with swallow, hemoptysis
laryngectomy
removes larynx, preserve plane of platysmal (save nerves/vessels), remove muscles, split thyroid, lay nerves laterally, cut away from pharynx and close pharynx, ***if person with stoma from laryngectomy needs air it must go through stoma - no connection between airway and mouth
case - 57, progressive hoarseness, no meds, healthy, nonsmoker, nondrinker, small paramedian neck mass
invasive thyroid cancer the is compressing recurrent laryngeal nerve to the larynx -> vocal cord paralyzed on one side, thyroid masses are mostly benign, workup -> ultrasound and needle biopsy, in surgical removal must take care to leave parathyroid glands and recurrent laryngeal nerve
case - 42, teacher, past smoker, nondrinker, variable hoarseness
vocal cord nodule, common in singers / speakers / teachers / lawyers, speech therapy, voice hygeine
signs of airway obstruction
stridor, respiratory effort, chest retraction, tracheal tug, intercostal retraction - little positive pressure will help breathing
stridor
laryngeal sound with airway obstruction, high pitch, inspiratory, then inspiratory and expiratory, 90% compromised airway, drop chest and raise abdomen = airway gone
sturdor
upper pharyngeal, gurgling, caused by swollen tonsils, pneumonia
croup
acute infection of larynx, slow onset 24-48 hrs, subglottic inflammation, viral / parainfluenza / RSV, inspiratory stridor, seal bark cough, rarely need intubation, Tx humidified air and steroids, steeple sign on PA film due to extended narrowing of airway below vocal cords
epiglottotis
WBC, blood culture, urine antigens, abrupt onset (hours), endoscopy with intubation, sit upright, hurts to swallow, intercostal and suprasternal retraction, lateral film shows thumbprint sign inflammed epiglotis, Tx antibiotics and intubation
ophthalamic zoster
prodrome, vesicular rash of C1 dermatome
subconjunctival hemorrhage
blood between conjunctiva and sclera, benign, trauma, coughing, labor, vomiting, valsalva, hypertension, diabetes mellitus, anticoagulants
eye globe pain
problem inside eye, iritis, uveitis, glaucoma, ophthalmologic consult
decreased visual acuity
risk of permanent vision loss, ophthalmologic consult
sluggish pupillary reflex
retinal or CNS problem, ophthalmologic consult
dendritic corneal lesion
HSV keratitis, ophthalmologic consult
vesicular lesions around eye
herpes zoster, ophthalmologic consult
signs of narrow angle glaucoma
sudden, pain, blurred vision, halos, subconjunctival hyperemia, corneal clouding, pupil dilation with absent / sluggish light response, increased IOP, risk factors: family hx, hyperopia, older, female, Asian / Inuit, pupil dilation with meds
correct use of ophthalmoscope
dark room, lens at 0 D, R hand/eye for R eye, L hand/eye for L eye, brace against your eye brow, pt looks over shoulder distantly, start 15 inches away and at 15 degrees off middle, look for red reflex, hand on pt forehead, advance toward pt
nose bleeds
most from ant nasal septum, called Kiesselbach’s area, terminal branches of sphenopalatine, ethmoidal, and superior labial arteries, posterior nose bleeds on septum or lateral wall supplies by sphenopalatine artery
Treacher Collins syndrome
first arch syndrome, deficient neural crest cell migration into arch, mandibulofacial dysostosis, abnormal dev of 1st arch structures - hypoplasia of upper and lower jaw, ext and middle ear deformation, palate and eyelid defects, conductive hearing loss, autosomal dominant or teratogenic, normal cognitive ability, mutation of TCOF1 gene on chromosome 5
Pierre Robin Syndrome
1st arch syndrome, deficient neural crest cell migration into arch, micrognathia, posterior tongue (airway obstruction - glossoptosis), U shaped palate, genetic/environmental, Tx tracheostomy and mandibular distraction
DiGeorge Syndrome
genetic / environmental, no thymus and parathyroid glands, causing diminished immunity and hypocalcemia, failure of neural crest cell migration causes failure of 3rd and 4th pouches and hypoplsia of 1st arch - cleft palate, low ears, poor feeding, delayed speech, heart defects, poor circulation, poor muscle tone
accessory or ectopic parathyroid glands
variable # and location, inferior may fail to descend or may be found in thorax with thymus
accessory or ectopic thymic tissue
found embedded in thyroid, near inferior parathyroid glands, or in isolated nests
lateral cervical or branchial cyst
ant edge of SCM, below angle of jaw, due to incomplete overgrowth of pharyngeal clefts by 2nd pharyngeal arch, epi inside may produce secretions causing cyst between 10-20 years old, may have a draining fistula
thyroglossal dust cyst of fistula
midline near hyoid, migrating thyroid that got caught up, epi secretions form cyst, infection likely
ectopic or accessory thyroid tissue
pieces of thyroid found anywhere along path of migration of thyroid
lingual thyroid
thyroid fails to descend from the base of the tongue, gland still works even though it is not in the right spot
blepharitis
infection of eye lid, stye
conjunctivitis
infection of conjunctiva
kerititis
infection of cornea
keratoconjunctivitis
infection of conjunctiva and cornea
uveitis
infection of iris, ciliary body, and choroid
chorioretinitis
infection of choroid and retina
endophthalmitis
infection of aqueous and vitreous humor
eye infections
outer surface protects, trauma, immunocompromised, dry eye, warm/moist under eyelid, deep layers invaded from brain/blood
eye defenses
sclera / cornea = physical barrier, tears with IgA and lysozyme, conjunctiva with lymphocytes/plasma cells/neutrophils/mast cells, blinking blocks attachment
conjunctivitis
discharge, red eye, irritation, sensitivity, no pain, no blurred vision, dilation of subepithelial vessels, can be viral, bacterial, allergic
bacterial conjunctivitis
mostly bilateral (spreads), thick discharge, red in older kids, occur with otitis media, no itchy
viral conjunctivitis
mostly unilateral, watery discharge, redness, little co-occurrance with otitis media, not itchy
allergic conjunctivitis
bilateral, little discharge, redness, no otitis media, very itchy