Week 3 MHC

Question 1

Th1

Answer 1

polarized - Il-12, il18 and ifngamma.
Effector ifn gamma and tnf
MTR tbet

Question 2

Th17

Answer 2

polarized il1, il6, il23, tgf-b
effector    il17, il22
MTR rorgammat
pro - inflammatory
maintaine integrity of mucosal surface

Question 3

Th2

Answer 3

polarized il4
effector il4, il5 il13
MTR GATA3
Heal and debris removal. il4 brings in eosinophil and stimulated b cells to make IgE

Question 4

Follicular helper

Answer 4

polarized il6, il21
effector il4, il21
mtr BCL-6
comm with b cell to differentiate in germ centers

Question 5

reg cd4

Answer 5

polarized il2 and tgf-b
effector il10 and tgf-b
MTR foxp3

Question 6

IPEX

Answer 6

lack of treg, cant stop immune system and get autoimmunte disease

Question 7

CTL activation

Answer 7

Il2 release from th1 for activation. ifngamma for activation

Question 8

HLA-B53

Answer 8

protection against malaria

Question 9

HLA-B27

Answer 9

ankylosing spondylitis (destroys vertebral cartilage) 90% more likely

Question 10

HLA DR2

Answer 10

130 more times narcolepsy

Question 11

HLA A3/B14

Answer 11

90x develop hemochromatosis (too much iron)

Question 12

HLA DQ2/GQ8

Answer 12

Celiac disease

Question 13

HLA DR3

Answer 13

dm type 1 and graves

Question 14

HLA DR4

Answer 14

ra and dm type 2

Question 15

cytochrome b5 reductase

Answer 15

low in children
cant convert fe3 to fe2
makes susceptible to nitrates

Question 16

treatment or nitrate poisoning

Answer 16

methylene blue
Need 20% threshold to treat!
it is cofactor for nadpha met hgb reductase

Question 17

lab findings for methemoglobinemia

Answer 17

heinz bodies with deep chocolate brown color

high methomoglobin