Week 3 Hypersensitivity and Autoimmunity

Question 1

Complement plays a major role in producing tissue damage in which hypersensitivity types?

a. Types I and II
b. Types I and IV
c. Types II and III
d. Types III and IV

Answer 1

c. Types II and III

Question 2

In this hypersensitivity reaction, antibody reacts with soluble antigen to form complexes that precipitate in the tissues:

Type IV
Type III
Type II
Type I

Answer 2

Type III

Question 3

Which of the following are the principle effector cells of immediate hypersensitivity?

T Lymphocytes
Macrophages
Basophils
Mast Cells

Answer 3

Mast Cells

Question 4

Which of the following statements about IgE testing is/are correct?

A. Total IgE result is an absolute predictor of allergy

B. In a positive RAST for antigen-specific IgE, the quantity of antibody measured definitely correlates with the severity of disease.

Statement B only
Statement A only
Both Statements
None of the statements

Answer 4

None of the statements

Question 5

Immunoglobulin type that is responsible for Cold Autoimmune Hemolytic Anemia and reacts strongly at <30 degrees Celsius?

Immunoglobulin M
Immunoglobulin D
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G

Answer 5

Immunoglobulin M

Question 6

Laboratory test for Type II hypersensitivity which aims to detect in-vivo binding of antibodies and antigens due hemolytic transfusion reactions:

Mantoux test
Patch test
Direct Coombs test
Indirect Coombs test

Answer 6

Direct Coombs test

Question 7

A localized type III reaction where immune complexes deposit in small dermal blood vessels:

Atopic Dermatitis
Contact dermatitis
Arthus Reaction
Serum Sickness

Answer 7

Arthus Reaction

Question 8

Peak time for Type IV hypersensitivity reactions to develop clinical signs and symptoms:
12-24 hours
Seconds to minutes
24-48 hours
48-72 hours

Answer 8

48-72 hours

Question 9

Which of the following fall under Type II hypersensitivity reactions?

I. Hashimoto’s thyroiditis

II. Multiple sclerosis

III. Rheumatoid Arthritis

IV. Hemolytic disease of the newborn

I and IV
II and III
I and II
II and IV

Answer 9

I and IV

Question 10

Which of the following fall under Type I hypersensitivity reactions?

I. Anaphylaxis
II. Allergic Rhinitis
III. Bronchial Asthma
IV. Atopic Dermatitis

I, II, III and IV
I and II
III and IV
I, II and III

Answer 10

I, II, III and IV

Question 11

Which of the following fall under Type III hypersensitivity reactions?

I. Arthus Reaction
II. Latex Allergy
III. Serum Sickness
IV. Eczema

I and II
III and IV
I, II and III
I and III

Answer 11

I and III

Question 12

Phenomenon where lymphocytes that recognize self antigens may be rendered functionally unresponsive:

Receptor Editing
Anergy
Molecular mimicry
Apoptosis

Answer 12

Anergy

Question 13

Neutrophil that has engulfed the antibody-coated nucleus of another neutrophil:

Smudge cell
Reed Sternberg cells
LE cell
Gaucher cell

Answer 13

LE cell

Question 14

Which antinuclear antibody is found in patient with drug-induced lupus erythematosus?

Anti-dsDNA
Anti-nucleolar
Anti-RNP
Anti-histone

Answer 14

Anti-histone

Question 15

In testing for ANA, which of the following results show positivity in Ouchterlony double diffusion test?

Color change of the substrate
Fluorescence staining patterns
Agglutination reaction
Immunoprecipitation lines of serological identity

Answer 15

Immunoprecipitation lines of serological identity

Question 16

A 27-year old female was admitted due to palpitations. Her vital signs show increased heart rate and her tremors were observed. Her eyes seem to bulge out. An anterior neck mass was noted which was soft and diffuse. The physician ordered for a thyroid panel. What could be the results of the tests?

Low T3 and T4
High T3 and T4
Normal T3 and T4

Answer 16

High T3 and T4

Question 17

In Type I diabetes mellitus, which cells of the islets of Langerhans are being destroyed by the autoantibodies?

Gamma cells
Alpha cells
Delta cells
Beta cells

Answer 17

Beta cells

Question 18

Inflammatory autoimmune disorder of the central nervous system characterized by the formation of lesions called plaques in the white matter of the brain and spinal cord:
Amyotrophic Lateral sclerosis
Multiple sclerosis
Myasthenia gravis
Grave’s disease

Answer 18

Multiple sclerosis

Question 19

The following human leukocyte antigens are associated with Early-Onset Myasthenia Gravis except for:

HLA-B7
HLA- A1
HLA-DR3
HLA-B8

Answer 19

HLA-B7

Question 20

A phenomenon where potentially self-reactive T-cell and B-cell clones are destroyed in the thymus and bone marrow respectively:

Autoimmunity
Central tolerance
Peripheral tolerance
Hypersensitivity

Answer 20

Central tolerance