Week 3 Biochem

Question 1

List the 4 Cardiac BioMarkers of the past and why they aren’t used any more:

Answer 1

1. Creatine Kinase
2. Lactate Dehydrogenase
3. Aspartate Aminotransferase (AST)
4. Myoglobin
   Because they are non-specific markers.

Question 2

Myoglobin is still used as a biomarker, but only in association with: _____ and _____.

Answer 2

1. Troponin

2. Creatine Kinase-MB

Question 3

Which CK-MB to CK Ratios indicate strong likelihood of MI occurrence?

Answer 3

Ratios higher than 2.5 to 3

Question 4

How can a possible MI be differentiated from Angina in diagnosis?

Answer 4

Angina, though it is defined as poor blood flow to the heart, presents with normal cTn levels. In the case of an MI, cTn levels would increase by at least 12 hrs.

Question 5

List 4 scenarios in which you would detect elevated

CK-MB that is NOT resulting from an MI:

Answer 5

1. Sk. Musc. Injury
2. Blunt Chest Trauma
3. Surgical Procedure Trauma
4. Cocaine Abuse

Question 6

How can you differentiate between an MI or non-MI case when elevated CK-MB land Troponin levels are detected?

Answer 6

Non-MI cases will present elevated CK-MB, but it won’t exhibit the normal rise, peak, and decline that you would see in an MI. Similarly, Troponin will exhibit a rise but not a peak.

Question 7

List 4 scenarios in which you would detect elevated

Troponin that is NOT resulting from an MI:

Answer 7

1. Myocarditis
2. Arrhythmia
3. Pulmonary Embolism
4. Hypertension