Week 3 Flashcards
(357 cards)
All adaptations of the human movement system are defined according to the ___ principle
All adaptations of the human movement system are defined according to the SAID principle
What does the SAID principle state?
Specific Adaptations can occur only in response to Imposed Demands
What is physical stress?
Adaptations imposed by mechanical loading
What are the ways to observe physical stress?
- Structural, functional, local and systemic changes
All adaptation begins at the ___ level
All adaptation begins at the cellular level
What is mechanotransduction?
The process by which the body converts physical stress into cellular responses
What do the the cellular responses from mechanotransduction promote?
Structural and functional adaptive change
What are the general steps of mechanotransduction?
- Mechano-coupling
- Cell to cell communication
- Effector response
What is mechano-coupling?
The mechanical trigger that initiates the process of mechanotransduction
What is the key to mechano-coupling?
The direct or indirect physical perturbation of the cell which is transformed into a variety of chemical signals both within and among cells
What is the critical point of understanding cell to cell communication?
The stimulus in one location, can lead to a distant cell registering a new signal, even though the distant cell did not receive a mechanical stimulus
What is the effector response?
The reaction to the mechanical stimulus to produce and assemble the necessary materials in the correct alignment for successful adaptation
What are the two pathways ignited by integrin proteins with movement in a tendon?
- Involves the cytoskeleton in direct physical communication with the nucleus( tension on the cytoskeleton sends a physical signal to the cell nucleus)
- Integrin acting on a series of biochemical signaling agents which after a series of intermediate steps, influence gene expression in the nucleus
What happens in the effector response once the cell nucleus receives the biochemical signals?
Normal cellular responses are engaged. mRNAs are transcribed and shuttled to the ER in the cell cytoplasm where is it translated into protein.
What happens to the protein in the effector response?
It is secreted and incorporated into extracellular matrix, hence the mechanical stimulus on the outside of the cell, promotes intra-cellular processes, leading to matrix remodeling
What are the characteristic responses of tissue to changes in the levels of physical stress?
- Maintenance of physical stress tolerance
- Increased physical stress tolerance
- Decreased physical stress tolerance
- Injury
- Death
When does the maintenance of physical stress tolerance occur?
When the physical loading is maintained in typical ranges and results in no apparent tissue change
When does the increase of physical stress tolerance occur?
When physical loading levels exceed maintenance range, but are still within adaptive capacity
What mechanism does increase muscle toleance to an increase of physical stress tolerance occur?
Hypertrophy
When does the decrease of physical stress tolerance occur?
When physical loading levels fall below maintenance range, resulting in decreased muscle tolerance in subsequent loading
What mechanism does increase muscle tolerance to an decrease of physical stress tolerance occur?
Atrophy
When does injury to tissues occur?
When physical loading levels exceed tissue tolerance beyond adaptive capacities
What are the things that can lead to injury of tissues?
- High magnitude loads of brief durations
- Low magnitude loads of long duration
- Moderate magnitude loads of excessive frequency or duration
Tissue injury results in ___ and initiation of the ___
Tissue injury results in tissue damage and initiation of the healing response