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Microbiology-Bacteria > Week 3 > Flashcards

Week 3 Flashcards

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Biology 101 flashcards
1
Q

Enterobacteriacea- how do they secrete stuff?

A

Type III= injection with needle thing

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2
Q

Enterobacteriacea- antigens?

A

O (Gram-), H, capsular Ag (K/Vi)

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3
Q

What do entero baceria do to inflamasomes?

A

They block them! they don’t want the inflamasome raising an alarm to activate the immune system!

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4
Q

What does legionella do in your cell that keeps it alive?

A

it blocks the phagolysosome, and just chills in the vesicle

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5
Q

Shigella- what does it do when it gets in the cell?

A

It shimmy’s out of the phagolysosome

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6
Q

Salmonella in phagolysosme?

A

It replicates.

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7
Q

3 infections e.coli can cause?

A

enteric, UTIs, sepsis/meningitis

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8
Q

Enteropathogenic e.coli

A

decrease brush border surface area= secretory diahrrea.

Major issue in young ones.

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9
Q

Enterohemorrhagic e.coli- what can it make that is systemic?

A

Produces toxins= Shigella or verotoxin with STX. Tropism for kidneys and causes hemolytic uremic syndrome

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10
Q

Hemolytic uremic syndrome

A 
caused by hemorrhagic e.coli
1. Diahrrea (starts watery--> bloody)
2. travels to kidneys
3. thrombocytopenia= damages platelets
4. Anemia 
5***BIG ONE IS KIDNEY DAMAGE!!***
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11
Q

What antibiotics can you use for hemolytic uremic syndrome?

A

NONE! IT WILL HELP THE TOXIN REPLICATE!!!!

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12
Q

How do you know its hemorrhagic e.coli (shigella/verotoxin) and not another e.coli?

A

no fever!

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13
Q

Enterotoxigenic e.coli

A

No cytoskeletal rearrangment.
Makes two heat stabile, and two heat labile toxins==> increased cAMP production===> watery diahhrea (travelers diahrrea)
secretory diahrreah

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14
Q

Enterotoxigenic e.coli is common in what countries?

A

Latin America> Africa> South Asia> SE Asia

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15
Q

Campylobacter is common?

A

in SE Asia

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16
Q

Enteroaggregative E. coli?

A

makes biofilm. It aggregates==»malabsorption diahrrea

Some cytotoxins, but main thing is the biofilm

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17
Q

Enteroinvasive e.coli

A

Shigella that looks like E.coli. Only e.coli that invades your cells.

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18
Q

Large intestine ones

A

Shigella (enteroinvasive) and enterohemmorragic

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19
Q

Can any e.coli survive crossign BBB?

A

Yes. E Coli K1= major cause of neonatal meningitis

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20
Q

Tell me about salmonella. What’s it look like?

A

Looks like E.coli.

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21
Q

What will they use to describe salmonella?

A

Ignore salmonella part, ignore subspecies part.

Salmonella enterica vs by serovars

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22
Q

Typch or paratyph?

A

ARE DIFFEERNT. They can invade shit and cause typhoid fever.

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23
Q

Typhoid fever

A

VERY HIGH FEVER. Weakness, stomach pain, headache. Rose rash. Transmitted by food/water contaminated by sewage. IE find it in places with bad sewage treatment

24
Q

Typhoid fever prevalence by country

A

India, Pakistan, Bangledash= 2/3 of all salmonella typhi or paratyphi

25
Q

If it can cause typhoid, what else can it do?

A

get in your blood= bacteremia.

26
Q

Most common foods that cause Salmonella?

A

Eggs and poultry, according to core. But I guess it’s also in peanut butter!!!

27
Q

Salmonella pathology

A

goes into brush border, down through basal membrane and enter macrophages. Then they live on and infect macrophages

28
Q

What can it do once it has disseminated? (salmonella)

A

Produce toxins and increase cytokine and prostaglandin stuff. This is why you can have bloody/watery diahhrea with salmonella

29
Q

Typhoid type

A

A1= like ptx
A2= hurts cells?
need mroe infor for this

30
Q

Shigella

A

S. Sonnei more common in US, but opposite in other worldly areas

31
Q

Shigella

A

chills in intestinal tract

watery diahrea==> bloody

32
Q

Shigella

A

Invade M-cells, break phagosome wall and chills in cytoplasm. No MHC II presentation. Macrophage kills the cell (how silly) and then shigella escapse and enters basolateral tract and breaks down some cell-cell adhesion. WBC leak into lumen==WBC in feces.

33
Q

4Fs. What are they? What are they in reference to?

A

Food, fingers, feces, flies. Shigella transmission. Mainly from gross kids that dont wash their hands and in places where the soil doesn’t freeze.

34
Q

General Dose requirement for shigella?

A

Low= high/fast transmission. Doesn’t take a lot!

35
Q

Shigella does something that listeria does too, what is it?

A

Actin polymerization

36
Q

Yersinia

A

BIPOLAR staining. (middle area not filled)= safety pin staining.

37
Q

Yersinia pestis

A 
Bubonic plague!!
Bubos form (balls of bacteria and pus) in inguinal regions...
38
Q

What things can cause Bubos?

A

Yersenia pestis, tularemia, pasteurella

39
Q

Hypertension, renal failure, and tachycardia=

A

BACTERIAL SEPSIS. KNOW THIS.

40
Q

DIC and Hypertension cause?

A

kills extremitites (is it still called gangrene?)

41
Q

Yersenia pestis transmission

A

fleas. They usually give it to animals. When animals start dying they move to humans. So I’m guessing that’s soemthing that would happen in the Zombie apocalypse.

42
Q

Antibiotic for plague? for septisemia

A

Tetracycline (no symptoms yet) or strptomycin (has symptoms)

43
Q

Klebsiellea pneumonia

A

?

44
Q

Klebsiella granulomatis

A

STD. “red beefy genitial ulcer” “soft ulcer” not painful

syph also not painful, but its a HARD ulcer.

45
Q

Most common infection in western world?

A

SEXUALLY TRANSMITTED INFECTIONS

46
Q

Proteus

A

can swarm–makes lots of flagella. Makes urease= alkaline urine and bladder stones

47
Q

What cause bladder stones?

A

Alkaline urine<==myco plasma OR proteus

48
Q

Antibiotic for proteus?

A

Ampicillin, cephalosporins, –see sheet

49
Q

why don’t they use fluoroquinomafj (Sp?) for UTIs?

A

Make biofilsm worse (from something)

ALso, resistance.

50
Q

UTI treatment- MOST COMMON?

A

BACTRAM

51
Q

Most common prophylactic antibitioc

A

Rifaximin. Not effective against camplobacter

52
Q

If you’re going to SE asia, what should you use? Why?

A

Azithromycin. for campylobacter–that’s what’s common there.

53
Q

Know four most common bacteria enteropathogens

A

campulo, salmonella, e.coli, shigella? –CHECK THIS

54
Q

What’s considered severe diahrea?

A

> 6/day
1 week
OR BLOOD
OR FEVER

55
Q

Dyentery?

A

blood stool and gut cramping.

56
Q

3 most common causes of

A

Staph, prestidiun prefinges, something else. sorry about spelling whiever sees this

57
Q

PS_I might have used SHigella for shiga toxin

A

i will try to fix before anyone sees it.

Microbiology-Bacteria (3 decks)

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