Week 3

Question 1

Name 2 types of acetylcholinesterase Inhibitors

Answer 1

Donepezil
Rivastigmine

Question 1

What is the common indication of Donepezil?

Answer 1

Mild to moderate Alzheimer’s disease

Question 2

What is the common indication for Rivastigmine?

Answer 2

Mild to moderate Parkinson’s disease

And

Mild to moderate Alzheimer’s disease

Question 3

What is the mechanism of action of donepezil and rivastigmine?

Answer 3

Inhibits cholinesterase enzyme

Prevents the breakdown of acetylcholine in the CNS

This will increase concentration of ACh in the brain

Improving cognitive function and reduces cognitive decline

Question 4

What are the common side effects for acetylcholineesterase inhibitors

Answer 4

GI upset- due to an increase of ACH in the peripheral nervous system

Question 5

What groups of people might experience an increased exacerbation of bronchospasms whilst taking donepezil ?

Answer 5

Asthma and COPD Patients

Question 6

True or false? People with risk of peptic ulcerations should use Donepezil with caution?

Answer 6

True