Week 2 - Shock And Stabilization Flashcards
Name conditions associated with distributive shock?
SIRS/Sepsis
Anaphylaxis/Anaphylactoid
Neurogenic
Neurogenic
Name conditions associated with obstructive shock?
Cardiac tamponade
Pleural space disease (effusion, pneumothorax, diaphragmatic hernia)
Pulmonary thromboemboli
GDV
What conditions are associated with non-circulatory shock?
Metabolic - mitochondrial dysfunction
Decreased O2 content - anaemia, Hb impairment
What is the equation for cardiac output?
Stroke volume x heart rate
What equation is this?
(SaO2 x Hb (g/l) x 1.37) + (PaO2 (mmHg) x 0.003
CaO2 - arterial oxygen content (ml/L)
What is the equation for delivery of oxygen DO2?
CO x CaO2
What is hypoxia?
Inadequate DO2 to meet the VO2 of the body
What are the 4 causes of hypoxia?
Decreased inspired O2
Inadequate tissue perfusion
Increased O2 demand
Cellular inability to DO2
What is the oxygen extraction ratio?
VO2 / DO2
What is critical O2 delivery?
O2 decreased, cells switch from aerobic to anaerobic metabolism.
What is hypoxemic hypoxia?
Decreased DO2 due to decreased CaO2 secondary to hypoxaemia from a decreased PaO2 and SaO2.
What is hypaemic hypoxia?
Decreased Hb thus reduces CaO2 thus decreasing DO2.
What is haemoglobinopathy?
Adequate Hb but Hb dysfunctional and unable to transport O2 sufficiently.
What is Stagnant/circulatory hypoxia?
Low CO and low blood load, leading to decreased DO2.
What is histotoxic hypoxia?
Adequate DO2 but tissues unable to extract and utilise O2.
Name a condition associated with histotoxic hypoxia?
Cyanide toxicity
Carbon monoxide toxicity
Mitochondrial dysfunction - Sepsis
What is metabolic hypoxia?
Adequate DO2 but increased VO2 demand (not enough to go around).
E.g. sepsis
Define shock.
VO2 exceeds DO2 and cells enter anaerobic metabolism.
What is dysoxia?
Cells unable to utilise O2 (Hisotoxic hypoxia).
What is apoptosis?
Cell death - leads to organ failure.
What is hypovolaemic shock?
Reduced volume in the intravascular space leading to decreased preload and cardiac output.
What is relative hypovolaemic shock?
Internal fluid shift from intravascular space e.g. internal haemorrhage, third spacing, massive vasodilation -sepsis.
What is absolute hypovolaemic shock?
External haemorrhage, excessive fluid loss e.g vomiting, diarrhoea, polyuria, endocrine disease.
What is distributive shock?
Systemic vasodilation
Give examples of conditions associated with distributive shock?
SIRs, SEPSIS, anaphylaxis/anaphylactoid, neurogenic shock.
What is cardiogenic shock?
Pump failure - contracting/filling leading to decreased CO and tissue hypoxia despite adequate intravascular volume.
Name conditions associated with cardiogenic shock?
Arrhythmias
Structural defect
Define obstructive shock.
Obstruction around the heart of blood vessels.
Give examples of conditions causing obstructive shock.
ATE
GDV
Pleural space disease
Cardiac tamponade
Blood back up in the right side of the heart leads to?
Cardiomegaly
Blood back up in the left side of the heart leads to?
Pulmonary oedema
Blood back up in the veins leads to?
Jugular venous distension
What is neurogenic shock?
Synthetic nervous system loses ability to stimulate nerve impulse - above T6 injury.
Give the clinical symptoms of compensatory shock
Increased: CO, BP, perfusion
Tachycardia, bounding pulses, brief CRT, pink MMC.
Give the clinical symptoms of early de-compensatory shock
Lactic acidosis
Tachycardia
Pulses weakening
Pale MMC, prolonged CRT
Tachypnoea, increased respiratory effort
Give the clinical symptoms for late decompensatory shock
Decreased CO and DO2
Bradypnoea, bradycardia, Hypotension, weak pulses, pale/cyanotic MMC, prolonged CRT, hypothermia.
In late decompensatory shock, what complications may present?
Protein loss due to increased epithelial permeability
Coagulopathies, DIC
AKD, ARDs, MODs
Dysrhythmias
Decreased mentation, coma and death
Define SIRs
Systemic inflammatory response syndrome secondary to widespread tissue isheamia and reperfusion injury.
Why does bacterial translocation occur in SIRs and what might result?
Intestinal tract is a portal for systemic inflammation and increased permeability leads to barrier dysfunction.
Sepsis may present.
Define DIC
Inflammation induced activation of the coagulation pathway leads to microthrombosis and DIC.
What is the blood volume of the cat?
60ml/kg
What is the blood volume of the dog?
90ml/kg
What are the three factors for Virchow Triad?
Vascular stasis
Hypercoagulability
Vascular trauma
What are the common places for catheter related blood stream infections to present?
Joint (hip/stifle)
Bladder
Fluid bolus recommendation dose?
5 - 20ml/kg over 10 - 20 minutes.
Hypertonic fluids cause?
A rapid fluid shift into the intravascular space causing rapid expansion of the intravascular fluid.