Week 2 Resp Flashcards
Obstruction of pulmonary artery or branch by blood clot, air, fat amniotic fluid, or septic thrombus is known as
PE
In PE, what happens with obstructed area?
Diminished or absent blood flow
Area is ventilated, but no gas exchange occurs
237000-nonfatal
294000- fatal
What is the pathology of PE?
Inflammatory process causes regional blood vessels to constrict, further increasing
1. Pulmonary vascular resistance, 2.Pulmonary artery presure
3. RIght Ventricular workload
In PE what may happen?
Ventilation-perfusion imbalance, RVF, and shock can occur
Name the Risk Factors for PE
Venous Stasis- d/t immobility
Hypercoagulability
Venous endothelial disease
Certain disease states- heart disease, trauma, postop/ postpartum, DM, COPD
-Pregnancy, obesity, oral contraceptives, constrictive clothing
Previous hx of thrmobophlebitis
Long bone fxs
What are the manifestations of PE?
Restless, anxiety, agitation
- Tachycardia, tachypnea, hypotension, fever
- Chest pain
-Hemoptysis
- Mental staus change
- decreased LOC
- Cyanosis
- Hx of thromboembolism
- Crackles
Describe how a PE forms
- Embolus breaks off
- Embolus travels through the vein to the lung
- Embolus travels through heart and gets dislodged in blood vessel of the lungs
How to prevent PE
Exercises to avoid venous stasis
Early ambulation
Anticoagulant therapy
SCDs
Tx of PE
Measures to improve resp., CV status
ANticoagulation, thrombolytic therapy
Mangement of PE includes
O2
Anticoagulants
Embolectomy
Thrombolytic therapy
Intracaval Filter
Phamacology for PE includes anticoags which are?
Heparin-P
Enoxaparin
Daltepaarin
Fondaparinux
Low molecular weight
SubQ vs IV
What vitamin k anatgonist can you give for PE?
Warfarin
Direct thrombin inhibitors for PE include
Dabigtran
Argatroban
Bivalirudin
Desirudin
Rivaroxaban
Factor Xa Inhibitors for PE include
Rovorxaban
Apixaban
Edoxaban
Antiplatlet drugs for PE include
Adenosine diphosphate receptor antagonists- Clopidogrel
Others- Aspirin, abciximab, dypyridamole
Thrombolytic drugs for PE include
Alteplase, Drotregogin alfa, reteplase, streptokinse, tenecteplase, urokinase
Drugs to control bleeding include
Aminocaproic acid
Prtoamine Sulfate
Tranexamic acid
Vitamin K- phytonadione
Interferes with the activation of fibrin and fibrinogen from thrombin and keeps the clots from forming
Heparin
Heparin prevents fibrin from what?
Clot and helps prevent DVT and PE. Prevents new clots from forming.
Rapid acting
IV or SUBq
Check Aptt
Need bleeding precautions
Heparin
RANDI
Bleeding precautions means what?
Razor-electric
A-NO
N- Needles small gauges
D- Decrease needle sticks
I- Protect from injury
With Heparin observe for ?
Hematuria
Nose Bleeds
Gingival bleeding
Bruising
Implement when using anticoags
Liver disease present
decreased platelets
Hemophilia present
When using thrombolytic medications
IVC umbrella filter used for
Capturing a clot
Name examples of chest trauma
Blunt trauma
Sternal, rib fractures
Flail chest
Pulmonary contusion; heart
Penetrating trauma
Hemothorax
Pneumothorax
Spontaneous or simple
Traumatic
Tension pneumthorax