Week 2, Morphine Flashcards
Morphine’s Pharmacologic Class: Opioid receptor agonist
Morphine’s Pharmacologic Class: Opioid receptor agonist
What is Morphine’s Pharmacologic Class?
Opioid receptor agonist
Morphine binds with both mu and kappa receptor sites to produce profound analgesia
Morphine binds with both mu and kappa receptor sites to produce profound analgesia
What receptor sites does Morphine bind to?
Mu and Kappa
What does Morphine produce after binding to Mu and Kappa receptors?
Profound analgesia
Morphine relieves shortness of breath associated with heart failure and pulmonary edema, and for acute chest pain connected with MI.
Morphine relieves shortness of breath associated with heart failure and pulmonary edema, and for acute chest pain connected with M I.
What does Morphine relieve?
Shortness of breath associated with heart failure and pulmonary edema, and for acute chest pain connected with MI.
Pregnancy category B (D in long-term use or with high doses).
Pregnancy category B (D in long-term use or with high doses).
What is Morphine’s Pregnancy category?
Pregnancy category B (D in long-term use or with high doses).
Morphine may cause severe respiratory depression, and physical/psychological dependance.
Morphine may cause severe respiratory depression, and physical/psychological dependance.
What can Morphine cause?
Morphine may cause severe respiratory depression, and physical/psychological dependance.
Cross tolerance develops between morphine and other opioids.
Cross tolerance develops between morphine and other opioids.
What develops between morphine and other opioids?
Cross tolerance.
Morphine may mask the pain of gallbladder disease, due to biliary tract spams.
Morphine may mask the pain of gallbladder disease, due to biliary tract spams.
What may Morphine mask the pain of?
Gallbladder disease, due to biliary tract spams.
When morphine is administered as an epidural drug, patients must be observed in a fully equipped and staffed environment for at least 24 hours.
When morphine is administered as an epidural drug, patients must be observed in a fully equipped and staffed environment for at least 24 hours.
How long should a patient be monitored after morphine is administered?
24 hours
Drug-Drug reactions:
Concurrent use of CNS depressants such as alcohol, other opioids, general anesthetics, sedatives, and antidepressants such as monoamine oxidase inhibitors (M A O Is) and T C As, potentiate the action of opiates, increasing the risk of severe respiratory depression and death.
Drug-Drug reactions:
Concurrent use of CNS depressants such as alcohol, other opioids, general anesthetics, sedatives, and antidepressants such as monoamine oxidase inhibitors (M A O Is) and T C As, potentiate the action of opiates, increasing the risk of severe respiratory depression and death.
Use of what in combination with morphine can cause respiratory depression and death?
CNS depressants, like alcohol and other opioids.
