week 2 mechanics of respiration cont Flashcards
Flow-Volume Loop
slide 31
Compliance is a measure of
the distensibility of the lungs
Compliance =
change in lung volume/ change in lung pressure
Cpulm = change of Vpulm / change of Ppulm
The extent of lung expansion is dependant on
increase of transpulmonary pressure
Normal static compliance is?
70-100 ml of air/cm of H2O transpulmonary pressure
is Compliance reduced by?
by higher or lower lung volumes, higher expansion pressures, venous congestion, alveolar edema, atelectasis & fibrosis
Compliance increased
with age & emphysema secondary to alterations of elastic fibers
Lung Volumes Changes Related To
Transpulmonary Pressure
pressure-volume curve
slide 36
Elastic Lung Tissue
- Elastin & Collagen fibers of lung parenchyma
- Natural state of these fibers is contracted coils
- Elastic force generated by the return to this coiled state after being stretched and elongated
- The recoil force assists to deflate lungs
Surface Air-fluid Interface
- 2/3 of total elastic force in lung
- Surface tension of H2O
Complex synergy between air & fluid holds alveoli open - Without air in the alveoli a fluid filled lung has only lung tissue elastic forces to resist volume changes
- Surfactant in the alveoli fluid reduces surface tension, keeps alveoli from collapsing
normal pt I:E ratio
1:2
copd or emphysema I:E ratio
1:3
Surface Tension Elastic Forces
The net effect on the lung to simultaneously
attempt to collapse alveoli by water tension
surfactant does what to the alveoli?
keeps them open. Surfactant lowers the surface tension of the alveoli fluid. reduces work of breathing.
surfactant is produced by what cell type?
Type II pneumocyte
DPPC-Dipalmitoyl phosphatidyl choline
- DPPC opposes water self-attractant elastic force to reduce alveolar surface tension
- Reduction of surface tension greater when film compressed closer as DPPC repel each other more