Week 2 - Exercise Metabolism Pt.1 Flashcards

1
Q

Describe bioenergetics

A

Bioenergetics involves the flow and exchange of energy within a living system, including the conversion of food into usable energy for cell work, with implications for performance

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2
Q

Define metabolism

A

Metabolism refers to the sum of all chemical reactions that occur in the body, including anabolic reactions for synthesis and catabolic reactions for breakdown of molecules

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3
Q

How do enzymes influence chemical reactions in the body

A

Enzymes are proteins that lower the activation energy and accelerate chemical reactions, thereby increasing the rate of product formation

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4
Q

Describe the process of oxidation-reduction reactions

A

Oxidation involves removing an electron (adding oxygen), while reduction involves adding an electron (removing oxygen), and these reactions are always coupled

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5
Q

What are the key characteristics of anaerobic pathways for ATP production

A

Oxygen Independent & Occurs in Cytosol

Substrate level phosphorylation (PCr system)
Most rapid and simplest method of producing ATP
Depleted after 10-15 seconds of maximal effort

Anaerobic glycolysis
§ Increased in by-products of ATP breakdown activates energy flux through reactions of the glycolytic pathway
Capacity is three-hold higher (30-90 secs) than PCr system
Net gain of glucose is 2 ATP molecules, Net gain of glycogen is 3 ATP, as it does not require phosphorylation by ATP

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6
Q

Explain the significance of the Citric Acid Cycle in aerobic ATP production

A

The Citric Acid Cycle generates high-energy electrons (NADH, FADH2), and ATP molecules through a series of reactions that occur in the mitochondria

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7
Q

How does temperature and pH influence enzyme activity

A

Temperature and pH can affect enzyme activity, with extremes leading to denaturation, impacting lactate threshold, H+ concentrtion, pH levels and ATP production

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8
Q

What are the classifications of enzymes

A

Kinases (add phosphate group)
Dehydrogenases (remove H atoms)
Oxidases (catalyse oxidation-reduction reactions involving oxygen)
isomerases (rearrangement of molecule)

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9
Q

Describe the role of coupled reactions in cellular chemical reactions

A

Coupled reactions involve the liberation of energy in an exergonic reaction to drive an endergonic reaction, ensuring energy transfer and balance within the cell

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10
Q

Describe the process of oxidative phosphorylation in mitochondria

A

Electrons are passed down a series of electron carriers, coupled with the pumping of H+ into the intermembrane space. Increased concentration of H+ ions in the intermembrane space leads to movement of H+ through ATP synthase, producing ATP. O2 is needed to accept these electrons to form H2O.

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11
Q

Define EPOC in exercise physiology

A

Exercise post-exercise oxygen consumption refers to the elevated oxygen uptake above rest during recovery from exercise. The magnitude and duration of EPOC are influenced by the intensity of the preceding exercise

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12
Q

How does energy systems change when influenced by exercise

A

High Intensity: ATP-PC system (<5s)
Intense Exercise: Anaerobic Glycolysis (>5s)
HIIT: 50% Anaerobic & Aerobic (>45s)
Prolonged Exercise: Aerobic (>10mins)

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13
Q

Define oxygen deficit

A

Discrepancy between initial demand and oxygen consumption

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14
Q

List some aerobic bioenergetic capacity adaptations endurance trained individuals have developed

A

Greater regional blood flow
Increased cellular adaptation and efficiency
Increased mitochondrial volume in muscle fibres results in less lactate production at beginning of exercise

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15
Q

What are some slow and fast components of EPOC

A

Fast: resynthesis of stored PC, muscle and blood O2 stores
Slow: Elevated HR and breathing, increased body temperature, elevated blood levels, conversion of lactic acid to glucose

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16
Q

What are some factors that influence fuel selection during exercise

A

Exercise intensity & duration.
Shift from fat to CHO metabolism
Recruitment of fast muscle fibres
Increasing blood levels of epinephrine
Breakdown of triglycerides (stimulated by several hormones such as epinephrine, norepinehprine and glucagon)

17
Q

Define beta-oxidation

A

The process of oxidising fatty acids to acetyl-CoA

18
Q

Define lactate threshold

A

The point at which blood lactate acid rises systematically during incremental exercise
Appears at 50-60% VO2 max for untrained individuals. 65-80% VO2 max in trained individuals

19
Q

What are some explanations for lactate threshold

A

Increased glycolysis (unable to transport NADH accumulation into mitochondria creates lactate)
Recruitment of fast-twitch muscle fibres (LDH isozyme higher affinity for pyruvate)
Reduced rate of lactate removal from blood (reduced blood flow to reduce lactate)

20
Q

Estimation of Fuel utilisation during exercise

A

RER is a good way to test
Ensure exercise is performed under steady state exercise
0 protein is used as fuel
0.7 = 100% fat oxidation, 1.0 = 100% carbohydrate oxidation