Week 2 Antimicrobials

Question 1

what are the 4 antibacterial mechanisms of actions?

Answer 1

affect:
cell wall synthesis
protein synthesis 
nucleic acid synthesis 
cell membrane function

Question 2

name the two types of ABs that affect cell wall synthesis?

Answer 2

beta-lactams

glycopeptides

Question 3

what 3 types of ABs affect protein synthesis?

Answer 3

tetracyclines
aminoglycosides
marolides

Question 4

name some general mechanisms of resisitance

Answer 4

bacteria produce drug inactivating enzymes
alter target- target enzymes has lower affinity for antibacterial
altered uptake- decrease permeability- ease to enter bacteria

Question 5

what are the 6 ideal features of antimicrobial agents?

Answer 5

selectively toxic
few adverse effects
reach site of infection
oral/IV formulation
long half life
no interference with other drugs