Week 2 Flashcards

1
Q

Define hepatocellular injury

A

hepatocyte inflammation and damage

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2
Q

Define Cholestatic

A

Impaired bile excretion

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3
Q

what are the roles of Liver Tests?

A
  • confirm a clinical suspicion of potential liver injury or disease
  • distinguish between hepatocellular injury and cholestasis
  • confirm medication appropriateness for hepatically cleared medicines
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4
Q

What are the 4 enzymes used to assess liver injury?

A
  1. ALT - alanine aminotransferase = liver
  2. AST - aspartate aminotransferase = liver, heart, muscles, kidney, brain, RBCs
  3. ALP - Alkaline phosphatase = liver, bone, placenta, biliary tract
  4. GGT - gamma glutamyltransferase = liver, bile duct
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5
Q

Elevated GGT indicates what?

A

cholestasis

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6
Q

Elevated ALT indicates what?

A
  • generalised damage to hepatocytes
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7
Q

What is the importance of Bilirubin as a marker?

A
  • liver conjugates and eliminates
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8
Q

What is the importance of Albumin as a marker?

A
  • synthesised by the liver
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9
Q

Prothrombin Time (PT) function

A

Time to clot formation

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10
Q
A
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