Week 2 Flashcards
1
Q
Define hepatocellular injury
A
hepatocyte inflammation and damage
2
Q
Define Cholestatic
A
Impaired bile excretion
3
Q
what are the roles of Liver Tests?
A
- confirm a clinical suspicion of potential liver injury or disease
- distinguish between hepatocellular injury and cholestasis
- confirm medication appropriateness for hepatically cleared medicines
4
Q
What are the 4 enzymes used to assess liver injury?
A
- ALT - alanine aminotransferase = liver
- AST - aspartate aminotransferase = liver, heart, muscles, kidney, brain, RBCs
- ALP - Alkaline phosphatase = liver, bone, placenta, biliary tract
- GGT - gamma glutamyltransferase = liver, bile duct
5
Q
Elevated GGT indicates what?
A
cholestasis
6
Q
Elevated ALT indicates what?
A
- generalised damage to hepatocytes
7
Q
What is the importance of Bilirubin as a marker?
A
- liver conjugates and eliminates
8
Q
What is the importance of Albumin as a marker?
A
- synthesised by the liver
9
Q
Prothrombin Time (PT) function
A
Time to clot formation
10
Q
A