Week 2

Question 1

What is the purpose of the haemostasis response?

Answer 1

Natural reaction to injury that causes bleeding

Reaction stops bleeding and allows body to being repair process

Question 2

What triggers the primary haemostasis response?

Answer 2

When blood is exposed to subendothelial collagen released from blood vessels after sustaining injury the primary haemostasis response is triggered

Question 3

What triggers the secondary haemostasis response?

Answer 3

The secondary haemostasis response is triggered by tissue factor, which is released by tissue cells after sustaining an injury

Question 4

What steps are involved in PH?

Answer 4

Vasoconstriction of blood vessels

Platelet plug formation (adhesion, aggregation, aggulation)

Question 5

What steps are involved in SH?

Answer 5

Fibrin is produced from a platelet factor cascade via the intrinsic, extrinsic and common pathways

Question 6

What is the structure of platelets?

Answer 6

Frgaemnts of cytoplasm derived from megakaryocytes

Biconcave unneucleated structure

Question 7

What is the main function of platelets?

Answer 7

Blood clotting - prevent bleeding

Question 8

What is the process of activation of platelets?

Answer 8

Collagen triggers adhesion, aggregation and agglutination of platelets to form a platelet plug

Question 9

Which factors are involved in the intrinsic pathway?

Answer 9

12+12a, 11+11a, 9+9a, 10+10a

Question 10

What factors are involved in the extrinsic pathway?

Answer 10

Tissue factor, 7+7a, 10+10a

Question 11

Which factors are involved in the common pathway?

Answer 11

10+10a, prothrombin, thrombin, fibrin, 13+13a