Week 2 Flashcards
what is nausea?
feeling the need to vomit, an unpleasant sensation in the mouth and stomach and can be associated with salvation , sweating, dizziness and tachycardia.
what is vomiting ?
forceful expulsion of stomach contents by the mouth , preceded by relaxation of the oesophageal sphincter and contraction of abdominal muscles and temporary suspension of breathing.
what is retching?
rhythmic contraction of abdominal muscles without emesis
what is GORD?
retrograde passage of gastric contents from the stomach into the oesophagus
what are the symptoms of GORD?
heartburn, pyrosis, regurgitation of gastric contents into the throat, early satiety, belching, hiccups, nausea and vomiting
what is motion sickness identified as?
a disagreement between visually perceived movement and the vestibular systems sense of movement
What are the main challenges in mixing?
Homogeneity difficult to acheive
Overmixing
Demising
What is a positive mixture?
Mixes spontaneously
What is a negative mixture?
Segregates spontaneously
What is a perfect mixture?
Completely homogeneous
Ordered mixture
Small particles absorbed and components move interdependently
What are the 3 different types of mixing?
Connective, shear,
Diffusive
What is the issue with static mixer ?
No moving parts, can cause clumping and powder adhesion
What are granules?
Preparations consisting of solid, dry aggregates of powder particles sufficiently resistant to withstand handling.
Describe wet granulation
- Solution binder is used
- particles are then dried
- Particles are sieved to choose particle size
