week 2 Flashcards

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1
Q

what growth measures are routinely collected in UK children

A

weight - baby, school age and sometimes pre school age
head circumference - only as a baby
length - only as a baby and if they cannot stand
height - after age 2
BMI - after age 2

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2
Q

how is weight measured

A

using clincal grade electronic scales
wearing light indoor clothes and no shoes
babies weighed naked

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3
Q

how is head circumference measured

A

using a non-elastic plastic tape

measured 3 times or more - until at least 2 are the same

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4
Q

how is length measured

A

using a stiff or rigid board

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5
Q

how is height measured

A

using rigid measure with t piece or stadiometer

shoes off, feet flat

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6
Q

what does it mean if a patient is outside +2SD or -2SD on a growth chart

A

not healthy at all

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7
Q

standard centile lines

A

lines on the growth chart are evenly spaced at 2/3 SD and include extreme outer centiles

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8
Q

what does a height on the 25th centile mean

A

should be around 25 children shorter and 75 taller

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9
Q

how did WHO build an ideal growth chart

A

6 different cohorts from around the world using the same protocol and criteria:
child healthy
breastfed for first 4 months and impartially for a year
no smoking
prosperous mothers

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10
Q

how to tell if an individuals growth is normal

A

both weight and height tend to track within one centile space
weight commonly varies over short term in pre school years due to illness
height may show wide variation due to measurement error

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11
Q

what makes a child short

A
genetic - polygenic inheritance 
rate of maturation - some grow faster than others
severe chronic illness and treatment
chromosomal anomolies: turners, downs
growth hormone deficiency 
chronic undernutrition
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12
Q

describe the 3 severities of malnutrition

A

severe acute malnutrition - below 3 standard deviations of median weight or height, visible severe wasting or presence of nutritional oedema
moderate malnutrition - weight loss and 2 to 3 SDs below the median weight or height
acute malnutrition - 1 to 2 SDs below median weight or height

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13
Q

3 types of malnutrition

A

mineral deficiency
protein energy malnutrion
avitaminosis

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14
Q

BMI for an obese adult

A

> 30 for obesity

>25 for overweight

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15
Q

what medical problems is obesity associated with

A
type II diabetes
ischaemic heart disease
cerebrovascular disease
osteoarthritis 
hypertension 
some cancers
psychological problems
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16
Q

social problems associated with obesity

A

body image dichotomy
difficulty engaging in some common social activities eg gym or employment
stigma

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17
Q

economic problems associated with obesity

A

sick leave

costs to NHS

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18
Q

causes of obesity

A
genetic predispositions
leptin and appetite control
insulin production and fat deposition
individual diet and exercise patterns
deprivation, learning disability, gender and race
obesogenic environment
technological progress
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19
Q

what is an obesogenic environment

A

readily available, cheap and heavily marketed energy rich foods
increase in labour saving devices eg lifts
increase in passive and motorised personal transport eg cars instead of walking
decreased participation i nactive leisure pursuits and total energy expenditure

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20
Q

milk-producing cells

A

lactocytes

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21
Q

function of oxytocin in breastmilk

A

stimulates myoepithelial cells to contract, pushing the milk into lactiferous ducts and towards the nipple

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22
Q

function of montgomery tubercles

A

glands which secrete a sebaceous fluid that lubricates the nipple and protects the skin
fluid has an individual aroma attracting infant to the mother

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23
Q

control of lactation

A

suckling sends powerful stimulus via higher sensors in the hypothalamus to posterior pituitary - secretes oxytocin
this acts on smooth muscle in alveoli which contract and inject milk into the lactiferous ducts
same stimulus acts on anterior pituitary to produce lactin - stimulates lactocytes to secrete milk for the next feed
milk contains feedback inhibitor of lactation which inhibits milk production when it accumulates

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24
Q

protein in human milk

A

main one is alpha lactalbumin and is associated with the destruction of over 40 types of cancer cells

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25
Q

carbohydrate in milk

A

Lactose is the main primary carbohydrate - provides 40% of total calories
improves the absorption of calcium and promotes growth of healthy bacteria

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26
Q

components of human milk not in formula

A
stem cells
growth factors 
immunoglobulins
leukocytes 
lactoferrin
oligosaccharides 
human milk lipids
IL-7
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27
Q

describe colostrum

A
first milk produced from breasts
from 16 weeks of pregnancy
consists of thick, yellowish fluid 
rich in vit A
antibodies and anti-infective proteins
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28
Q

benefits of breastfeeding

A

immune protection:
breastfeeding activates broncho-entero-mammary pathway - when mother inhales pathogens, lymph nodes in the lungs and small intestine manufacture specially sensitised lymphocytes which migrate to the breasts and create antibodies
promotes development of the brain:
contains long-chain polyunsaturated fatty acids such as docosahexaenoic which support brain development and intelligence
promotes maturation of gut:
epidermal GF promotes healing, neuronal GFs promote development of peristalsis - help reduce chance of necrotising enterocolitis
protects mothers health:
protects against postpartum haemorrhage and depression, ovarian and breast cancers, heart disease and type II diabetes

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29
Q

importance of skin to skin contact

A

triggers lactation and mothering hormones
triggers calming hormones in the baby
stimulates digestion
stimulates instinctive feeding behaviors
enables infants skin to become colonised by protective bacteria from mothers skin

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30
Q

positioning during breastfeeding

A
CHIN
keep baby Close
baby will tilt Head back 
baby's head and body should be In line
Nose to nipple
31
Q

role of oxytocin in babies

A

when they feel secure they release oxytocin

vital for brain development

32
Q

doctors role in breastfeeding

A

encourage and discuss importance
encourage skin to skin contact
acknowledge mother may need support
avoid advising supplementary bottle feeds just to allay anxiety
dont prescribe medication without checking safety for lactation

33
Q

breastfeeding as a societal issue

A

breasts still seen as sexual
little support for breast feeding in public or long-term breastfeeding
media portrays bottle feeding

34
Q

breastfeeding as an economical issue

A

not breastfeeding is associated with lower intelligence and economic losses
failing to breastfeed costs global economy

35
Q

aim of an immunisation programme

A

to protect those at highest risk (selective immunisation stategy)
or
to eradicate, eliminate or contain disesae (mass immunisation strategy)

36
Q

describe selective vaccination

A
vaccine does not need to be given to all, only those at increased risk of disease:
travel
high risk groups
occupational risk 
outbreak control
37
Q

describe mass vaccination

A

eradication - disease and causal agent removed worldwide
elimination - disease disappeared from one WHO region but remains elsewhere
containment - disease no longer constitutes a significatn public health problem

38
Q

aim of an ideal vaccine

A

to produce the same immune protection which usually follows natural disease but without causing the disease
to generate long-lasting immunity
to interrupt spread of infection

39
Q

contradictions and precautions of vaccinations

A

those with primary or acquired immunodefiency
those on immunosuppressives, including biological therapy
pregnant women
infants born to a mother who received immunosuppressive biological therapy during pregnancy
those in contact with an individual with immunodeficiency, current recent immunosuppressive including biological therapy

40
Q

what are live vaccines

A

attenuated (weakened) strains which replicate in host
act like natural infection
closest to actual infection and therefore elicit good, strong, long-lasting immune responses

41
Q

examples of live vaccines

A

MMR
BCG
yellow fever

42
Q

what are inactivated vaccines

A

do not contain a pathogen capable of replicating and causing disease

43
Q

live v inactivated vaccines

A
live:
longer lasting immunity
strong immune response evoked
can revert to virulence
poor stability
cannot use in pregnancy or immunosupressed
inactivated:
shorter lasting immunity
adjuvant needed
unable to cause infection 
stable 
constituents clearly defined
less contradictions
need several doses
local reactions common
44
Q

describe herd immunity

A

for. each disease there is a certain level of immunity in the population which protects the whole population because the pathogen stops spreading within the community
provides indirect protection of unvaccinated individuals

45
Q

examples of vaccine preventable diseases

A
bacterial:
diphtheria
tetanus
TB
pertussis (whooping cough)
meningococcal c disease
pneumococcal disease
viral:
measles
mumps
rubella
HPV
varicella
Hep b
influenza
poliomyelitis
46
Q

what is passive immunity

A

provides protection at, or around the time of exposure to a specific pathogen
given to individuals who are at high risk of severe disease or of developing severe complications from the disease
they provide immediate but temporary protection
does no stimulate the immune system to make any antibodies

47
Q

example of passive immunity

A

transplacental - most important source in newborn

48
Q

types of antibody preparations

A

human source - pooled blood preparations from donors (plasma or immunoglobulin)
monoclonal
animal source

49
Q

examples of antibodie preparations from human sources

A

hepatitis b immunoglobulin
human rabies immunoglobulin
tetanus immunoglobulin

50
Q

antibody preparation pros and cons

A

pros:
rapid, preventative, can be given to those where vaccine is contradicted
cons:
expensive, potential for adverse events, limited evidence base for some, no lasting immunity

51
Q

factors influencing a vaccine

A
benefit to others
fidelity (keep commitments)
autonomy
no harm
transparency (reasons behind)
justice
utility (helping great amount of people)
trust 
privacy (sharing of data)
risk
effectiveness
reciprocity (taking vaccine when healthy - some become unhealthy)
52
Q

questions to consider when developing a vaccine programme

A

is there a need for the vaccine? - does it cause a significant health problem
is a suitable vaccine available that is safe and effective?
can the programme be delivered in a safe, effective and cost-effective manner?
what is the aim of the programme?

53
Q

what is surveillance of a vaccine programme

A

the ongoing, systematic collection, recording, analysis, interpretation and disseminaton of data

54
Q

when does surveillance of a vaccine programme need to occur

A
pre-implementation:
to estimate burden of disease
to decide vaccine strategy
post implementation:
to monitor effectiveness of vaccine strategy
55
Q

issues in vaccine policy decisions

A
disease incidence, vaccine safety, efficacy from surveillance
aim of programme
cost of programme
population accessibility
cultural attitudes and practices
facilities available for delivery
56
Q

symptoms of pertussis

A
initially: cold-like symptoms 
followed by:
gradually worsening cough
paroxysms of coughing
characteristic whoop
post-tussive vomiting
conjuctival haemorrhage
57
Q

complications of pertussis

A

respiratoy - majority of cases involve a collapsed lung and/or pneumonia
neurological - lack of oxygen leading to altered consciousness, convulsions, permanent brain damage, death
severe weight loss and dehydration due to vomiting
sudden death

58
Q

history of pertussis vaccines

A

whole cell vaccine used until 2004
rates dropped to 30% in 1975 due to anxiety about safety
epidemics between 1977 and 1983
acellular vaccine added to preschool booster in 2001 and replaced whole cell vaccine in 2004

59
Q

current issues with pertussis

A

some evidence of vaccine waning with age
pertussis remains the most common vaccine preventable disease in <1y with highest mortality
2012 temporary programme to offer vaccine to pregnant women weeks 28 and 32 - 2014 programme extended for at least 5 years
2016 advice changed so vaccine given from week 16

60
Q

challenges of global immunisation

A
funding, coverage, uptae
surveillance
different priorities, different vaccines
multiple agencies: bill and melinda gates, UNICEF
suspicion, mistrust
violence - war, civil unrest
61
Q

difference between active immunity and passive immunity

A

active - protection produced by a persons own immune system by natural infection or artificial immunisation means
passive - protection transferred from another person or animal as antibody. can be natural (transplacental) or artifical (immunoglobulin)

62
Q

vaccine definition

A

induced immunity using vaccine

63
Q

immunisation definition

A

vaccine induced immunity and the transfer of antibodies/immunoglobulins

64
Q

antigen definition

A

a live or inactivated substance capable of producing an immune response
or
any substance than be bound by an antibody

65
Q

antibody definition

A

immunoglobulin produced by b lymphocytes to help eliminate a pathogen

66
Q

polysaccharide v conjugate vaccines

A

polysaccharide:
t-cell independent
less immunogenic in under 2s
no booster response - immune response after 2nd dose is similar to 1st dose
conjugate:
polysaccharide antigen linked to a protein antigen (strong anitgen with weak antigen - strong immune response to weak antigen)
conjugates can include toxoids, CRM197
designed to enhance immune response, particularly in children under 2y/o

67
Q

components of a vaccine

A

stabilisers - prevent components adhering to side of vial
trace components
preservatives
antibiotics
adjuvants - substance that enhances immune response in presence of an antigen

68
Q

purpose of intervals between vaccines

A

to allow each immune response to develop

to avoid immune interference

69
Q

primary v secondary vaccine failure

A

primary - no/limited response

secondary - immunity wanes over time

70
Q

frequency of adverse events in live and inactivated vaccines

A

live - reduces with additional dose

inactive - increases with additional dose

71
Q

timing of adverse events in live and inactivated vaccines

A

live - depends on time for pathogen to replicate

inactive - generally within 48 hours of vaccine

72
Q

what is the reproduction number

A

r = the effective reproduction number
number of secondary infections produced by a typical infective
r0 = basic reproduction number
number of secondary infections produced by a typical infective in a totally susceptible population
R0>1 = epidemic possible

73
Q

herd immunity threshold

A

HIT = 1 - (1/R0)
how many people we need to vaccinate to prevent epidemic
also called critical vaccine threshold