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Carelab Top 200 > Week 14 Fall > Flashcards

Week 14 Fall Flashcards

1
Q

tolterodine (Detrol LA)

MOA

A

Tolterodine and its active metabolite are competitive antagonists of acetylcholine at muscarinic receptors. In the bladder, this results in relaxation of the detrusor muscle which reduces urinary incontinence, urgency, and frequency symptoms

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2
Q

tolterodine (Detrol LA)

Efficacy

A

Decreased symptoms of bladder overactivity

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3
Q

tolterodine (Detrol LA)

Safety

A

Liver function tests

Serum Creatinine

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4
Q

tolterodine (Detrol LA)

BBW

A

none

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5
Q

tolterodine (Detrol LA)

Precautions

A

caution may cause serious hypersensitivity reactions including angioedema and anaphylaxis; cause anticholinergic side effects (i.e. agitation, confusion, drowsiness, dizziness, hallucinations, headache, and/or blurred vision); dose-dependent QT prolongation, caution in patients with other risk factors for arrhythmias or with concurrent use of other medications that prolong QT; may increase risk of heat prostration, caution with extreme heat or strenuous exercise; caution in bladder flow obstruction; caution in patients with GI motility disorders or GI obstructive disorders; caution in glaucoma; caution in BPH; caution in myasthenia gravis; caution in elderly; caution with CYP3A4 inhibitors

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6
Q

tolterodine (Detrol LA)

ADR

A

Common: Xerostomia, Constipation, Headache, Dizziness
Rare: Angioedema, QT prolongation

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7
Q

tolterodine (Detrol LA)

Contraindications

A

Hypersensitivity to tolterodine or fesoterodine or any component of the product; urinary retention; gastric retention; uncontrolled narrow-angle glaucoma

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8
Q

tolterodine (Detrol LA)

Dose Adjust

A

R: Adjust
H: Adjust

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9
Q

darifenacin (Enablex)

MOA

A

Darifenacin is a selective antagonist of the M3 cholinergic receptor in the bladder. This results in relaxation of the detrusor muscle which reduces urinary incontinence, urgency, and frequency symptoms

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10
Q

darifenacin (Enablex)

Efficacy

A

Decreased symptoms of bladder overactivity

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11
Q

darifenacin (Enablex)

Safety

A

See ADR
Common: Xerostomia, Constipation, Headache
Rare:Angioedema, Heat prostration

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12
Q

darifenacin (Enablex)

BBW

A

none

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13
Q

darifenacin (Enablex)

Precautions

A

caution may cause serious hypersensitivity reactions including angioedema and anaphylaxis; cause anticholinergic side effects (i.e. agitation, confusion, drowsiness, dizziness, hallucinations, headache, and/or blurred vision); may increase risk of heat prostration, caution with extreme heat or strenuous exercise; caution in bladder flow obstruction; caution in patients with GI motility disorders or GI obstructive disorders; caution in glaucoma; caution in BPH; caution in myasthenia gravis; caution in elderly; caution with CYP3A4 inhibitors

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14
Q

darifenacin (Enablex)

ADR

A

Common: Xerostomia, Constipation, Headache
Rare:Angioedema, Heat prostration

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15
Q

darifenacin (Enablex)

Contraindications

A

Hypersensitivity to darifenacin or any component of the product; uncontrolled narrow-angle glaucoma; urinary retention; paralytic ileus; GI or GU obstruction

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16
Q

darifenacin (Enablex)

Dose Adjust

A

R: none
H: Adjust

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17
Q

terazosin (Hytrin)

MOA

A

In hypertension, competitively inhibits post-synaptic alpha1-adrenergic receptors causing vasodilation and decrease in blood pressure
In BPH, competitively inhibits post-synaptic alpha1-adrenergic receptors in the prostate and bladder tissues, decreasing smooth muscle tone and reducing BPH symptoms

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18
Q

terazosin (Hytrin)

Efficacy

A

Urinary symptoms

Blood pressure

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19
Q

terazosin (Hytrin)

Safety

A

Standing and sitting blood pressure

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20
Q

terazosin (Hytrin)

BBW

21
Q

terazosin (Hytrin)

Precautions

A

caution may cause orthostasis with/without syncope, risk highest during initiation, interruption in therapy for a few days, dose increases, concurrent use of other antihypertensives or phosphodiesterase-5 inhibitors; priapism may occur; must rule out prostate cancer prior to initiation; caution in elderly due to orthostasis risk; risk of intraoperative floppy eye syndrome in cataract surgery

22
Q

terazosin (Hytrin)

ADR

A

Common: Dizziness, Orthostatic hypotension, Headache, Syncope
Rare: Floppy iris syndrome, Priapism, Angina

23
Q

terazosin (Hytrin)

Contraindications

A

Hypersensitivity to terazosin or any component of the product

24
Q

terazosin (Hytrin)

Dose Adjust

A

R: none
H:none

25
Q

oxybutynin (Ditropan XL)

MOA

A

Oxybutynin has a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. This results in bladder smooth muscle relaxation and suppression of the urge to void.

26
Q

oxybutynin (Ditropan XL)

Efficacy

A

Decreased symptoms of bladder overactivity

27
Q

oxybutynin (Ditropan XL)

Safety

A

See ADR
Common: Xerostomia, Constipation, Dizziness, Drowsiness, Nausea
Rare: Angioedema, Heat prostration

28
Q

oxybutynin (Ditropan XL)

BBW

29
Q

oxybutynin (Ditropan XL)

Precaution

A

caution may cause serious hypersensitivity reactions including angioedema and anaphylaxis; cause anticholinergic side effects (i.e. agitation, confusion, drowsiness, dizziness, hallucinations, headache, and/or blurred vision); may increase risk of heat prostration, caution with extreme heat or strenuous exercise; caution in bladder flow obstruction; caution in patients with CAD, heart failure, or arrhythmias; caution in patients with dementia on cholinesterase inhibitors; caution in patients with GI motility disorders or GI obstructive disorders; caution in glaucoma; caution in Parkinson’s disease; caution in BPH; caution in myasthenia gravis; caution in elderly

30
Q

oxybutynin (Ditropan XL)

ADR

A

Common: Xerostomia, Constipation, Dizziness, Drowsiness, Nausea
Rare: Angioedema, Heat prostration

31
Q

oxybutynin (Ditropan XL)

Contraindications

A

Hypersensitivity to oxybutynin or any component of the product; uncontrolled narrow angle glaucoma; urinary retention; gastric retention or severely decreased GI motility

32
Q

oxybutynin (Ditropan XL)

Dose Adjust

A

R: none
H: none

33
Q

tamsulosin (Flomax)

MOA

A

Tamsulosin works as a selective antagonist at alpha-1 receptors in the prostate. Blockade of alpha-1 receptors leads to smooth muscle relaxation in the bladder neck and prostate. This results in improved urine flow rate and symptoms of benign prostatic hypertrophy.

34
Q

tamsulosin (Flomax)

Efficacy

A

Urinary symptoms

35
Q

tamsulosin (Flomax)

Safety

A

Standing and sitting

Blood pressure

36
Q

tamsulosin (Flomax)

BBW

37
Q

tamsulosin (Flomax)

Precautions

A

caution may cause orthostasis with/without syncope, risk highest during initiation, interruption in therapy for a few days, dose increases, concurrent use of other antihypertensives or phosphodiesterase-5 inhibitors; priapism may occur; must rule out prostate cancer prior to initiation; caution in elderly due to orthostasis risk; risk of intraoperative floppy eye syndrome in cataract surgery; possible cross reactivity with sulfa allergy but rare

38
Q

tamsulosin (Flomax)

ADR

A

Common: Dizziness, Orthostatic hypotension, Headache, Syncope
Rare: Floppy iris syndrome, Priapism, Angina

39
Q

tamsulosin (Flomax)

Dose Adjust

A

R: none
H: none

40
Q

tamsulosin (Flomax)

Contraindications

A

Hypersensitivity to tamsulosin or any component of the product

41
Q

solifenacin (Vesicare)

MOA

A

Solifenacin is a competitive antagonist of acetylcholine at muscarinic receptors, specifically the M3 cholinergic receptor in the bladder. This results in relaxation of the detrusor muscle which reduces urinary incontinence, urgency, and frequency symptoms

42
Q

solifenacin (Vesicare)

Efficacy

A

Decreased symptoms of bladder overactivity

43
Q

solifenacin (Vesicare)

Safety

A

See ADR
Common: Xerostomia, Constipation, Headache
Rare: Angioedema, Heat prostration

44
Q

solifenacin (Vesicare)

BBW

45
Q

solifenacin (Vesicare)

Precaution

A

caution may cause serious hypersensitivity reactions including angioedema and anaphylaxis; cause anticholinergic side effects (i.e. agitation, confusion, drowsiness, dizziness, hallucinations, headache, and/or blurred vision); dose-dependent QT prolongation, caution in patients with other risk factors for arrhythmias or with concurrent use of other medications that prolong QT; may increase risk of heat prostration, caution with extreme heat or strenuous exercise; caution in bladder flow obstruction; caution in patients with GI motility disorders or GI obstructive disorders; caution in glaucoma; caution in BPH; caution in myasthenia gravis; caution in elderly; caution with CYP3A4 inhibitors

46
Q

solifenacin (Vesicare)

ADR

A

Common: Xerostomia, Constipation, Headache
Rare: Angioedema, Heat prostration

47
Q

solifenacin (Vesicare)

Contraindications

A

Hypersensitivity to solifenacin or any component of the product; urinary retention; gastric retention; uncontrolled narrow-angle glaucoma

48
Q

solifenacin (Vesicare)

Dose Adjust

A

R: Avoid
H: Avoid

Carelab Top 200 (2 decks)

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